Alina Constantinescu

2025

The tacrolimus concentration-to-dose ratio is associated with kidney function in heart transplant recipients

Schagen, M. R., Petersen, T. B., Seijkens, B. C. A., Brugts, J. J., Caliskan, K., Constantinescu, A. A., de Winter, B. C. M., Kardys, I., Hesselink, D. A. & Manintveld, O., 19 Mar 2025, In: British Journal of Clinical Pharmacology. 15 p.

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Early Postoperative Changes in Von Willebrand Factor Activity Are Associated With Future Bleeding and Stroke in HeartMate 3 Patients

Jahangiri, P., Veen, K. M., van Moort, I., Bunge, J. H., Constantinescu, A., Sjatskig, J., de Maat, M., Kluin, J., Leebeek, F. & Caliskan, K., 1 Jan 2025, In: ASAIO journal (American Society for Artificial Internal Organs : 1992). 71, 1, p. 27-35 9 p.

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2024

Temporal evolution of anxiety and depression in chronic heart failure and its association with clinical outcome

Abou Kamar, S., Oostdijk, B., Andrzejczyk, K., Constantinescu, A., Caliskan, K., Akkerhuis, K. M., Umans, V., Brugts, J. J., Boersma, E., van Dalen, B. & Kardys, I., 15 Sept 2024, In: International Journal of Cardiology. 411, 132274.

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3 Citations (Scopus)

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Proteomic biomarkers related to obesity in heart failure with reduced ejection fraction and their associations with outcome

Petersen, T. B., Suthahar, N., Asselbergs, F. W., de Bakker, M., Akkerhuis, K. M., Constantinescu, A. A., van Ramshorst, J., Katsikis, P. D., van der Spek, P. J., Umans, V. A., de Boer, R. A., Boersma, E., Rizopoulos, D. & Kardys, I., Sept 2024, In: Obesity. 32, 9, p. 1658-1669 12 p.

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Temporal changes in CT-derived fractional flow reserve in patients after heart transplantation

Sharma, S., Sanz, J., Hirsch, A., Patel, R., Constantinescu, A., Barghash, M., Mancini, D., Brugts, J., Caliskan, K., Taverne, Y., Manintveld, O. & Budde, R., 17 Jul 2024, In: European Radiology. 35, 1, p. 232-243 12 p., e14167.

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Temporal evolution of liver function parameters predicts clinical outcome in chronic heart failure patients (Bio-SHiFT study)

Klimczak-Tomaniak, D., Andrzejczyk, K., Kamar, S. A., Baart, S., Boven, N. V., Akkerhuis, K. M., Constantinescu, A., Caliskan, K., Simsek, S., Germans, T., Ramshorst, J. V., Brugts, J., Kuch, M., Umans, V., Boersma, E. & Kardys, I., 2024, In: Cardiology Journal. 31, 3, p. 409-417 9 p.

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2023

Pectus Excavatum and Risk of Right Ventricular Failure in Left Ventricular Assist Device Patients

Zijderhand, C. F., Yalcin, Y. C., Sjatskig, J., Bos, D., Constantinescu, A. A., Manintveld, O. C., Birim, O., Bekkers, J. A., Bogers, A. J. J. C. & Caliskan, K., 9 Nov 2023, In: Reviews in Cardiovascular Medicine. 24, 11, 313.

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Long-Term Outcome of ICD Therapy in Patients With Noncompaction Cardiomyopathy Compared With DCM and HCM

Kaya, E., Otten, M., Theuns, D. A. M. J., Veen, K., Yap, S.-C., Schinkel, A. F. L., Constantinescu, A. A., Michels, M., Manintveld, O. C., Szili-Torok, T. & Caliskan, K., Aug 2023, In: JACC: Clinical Electrophysiology. 9, 8, p. 1368-1378 11 p.

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Potential role of left atrial strain in estimation of left atrial pressure in patients with chronic heart failure

Aga, Y. S., Abou Kamar, S., Chin, J. F., van den Berg, V. J., Strachinaru, M., Bowen, D., Frowijn, R., Akkerhuis, M. K., Constantinescu, A. A., Umans, V., Geleijnse, M. L., Boersma, E., Brugts, J. J., Kardys, I. & van Dalen, B. M., Aug 2023, In: ESC heart failure. 10, 4, p. 2345-2353 9 p.

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8 Citations (Scopus)

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Veen, K. M., Papageorgiou, G., Zijderhand, C. F., Mokhles, M. M., Brugts, J. J., Manintveld, O. C., Constantinescu, A. A., Bekkers, J. A., Takkenberg, J. J. M., Bogers, A. J. J. C. & Caliskan, K., Jun 2023, In: Frontiers of Medicine. 17, 3, p. 527-533 7 p.

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2 Citations (Scopus)

Mechanical Device Malfunction of the HeartMate II Versus the HeartMate 3 Left Ventricular Assist Device: The Rotterdam Experience

Van Der Heiden, C. W., Zijderhand, C. F., Veen, K. M., Constantinescu, A. A., Manintveld, O. C., Brugts, J. J., Bekkers, J. A., Birim, O., Bogers, A. J. J. C. & Caliskan, K., 1 Feb 2023, In: ASAIO Journal. 69, 2, p. E80-E85

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The Dutch national paediatric heart transplantation programme: outcomes during a 23-year period

Roest, S., van der Meulen, M. H., van Osch-Gevers, L. M., Kraemer, U. S., Constantinescu, A. A., de Hoog, M., Bogers, A. J. J. C., Manintveld, O. C., van de Woestijne, P. C. & Dalinghaus, M., Feb 2023, In: Netherlands Heart Journal. 31, 2, p. 68-75 8 p.

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2022

Heart failure subphenotypes based on repeated biomarker measurements are associated with clinical characteristics and adverse events (Bio-SHiFT study)

de Lange, I., Petersen, T. B., de Bakker, M., Akkerhuis, K. M., Brugts, J. J., Caliskan, K., Manintveld, O. C., Constantinescu, A. A., Germans, T., van Ramshorst, J., Umans, V. A. W. M., Boersma, E., Rizopoulos, D. & Kardys, I., 1 Oct 2022, In: International Journal of Cardiology. 364, p. 77-84 8 p.

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4 Citations (Scopus)

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Relapsing low-flow alarms due to suboptimal alignment of the left ventricular assist device inflow cannula

Zijderhand, C. F., Knol, W. G., Budde, R. P. J., van der Heiden, C. W., Veen, K. M., Sjatskig, J., Manintveld, O. C., Constantinescu, A. A., Birim, O., Bekkers, J. A., Bogers, A. J. J. C. & Caliskan, K., 1 Oct 2022, In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 62, 4, ezac415.

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3 Citations (Scopus)

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Prevalence of Iron Deficiency and Iron Administration in Left Ventricular Assist Device and Heart Transplantation Patients

Veenis, J. F., Radhoe, S. P., Roest, S., Caliskan, K., Constantinescu, A. A., Manintveld, O. C. & Brugts, J. J., Jul 2022, In: ASAIO Journal. 68, 7, p. 899-906 8 p.

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5 Citations (Scopus)

Single-Center Experience With Protocolized Treatment of Left Ventricular Assist Device Infections

Verkaik, N. J., Yalcin, Y. C., Bax, H. I., Constantinescu, A. A., Brugts, J. J., Manintveld, O. C., Birim, O., Croughs, P. D., Bogers, A. J. J. C. & Caliskan, K., 24 May 2022, In: Frontiers in Medicine. 9, 6 p., 835765.

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2 Citations (Web of Science)

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Oral Glucose Tolerance Test for the Screening of Glucose Intolerance Long Term Post‐Heart Transplantation

Roest, S., Goedendorp-Sluimer, M. M., Köbben, J. J., Constantinescu, A. A., Taverne, Y. J. H. J., Zijlstra, F., Zandbergen, A. A. M. & Manintveld, O. C., 19 Apr 2022, In: Transplant International. 35, 10113.

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Cardiac allograft vasculopathy and donor age affecting permanent pacemaker implantation after heart transplantation

Roest, S., Manintveld, O. C., Kolff, M. A. E., Akca, F., Veenis, J. F., Constantinescu, A. A., Brugts, J. J., Birim, O., van Osch-Gevers, L. M., Szili-Torok, T. & Caliskan, K., Apr 2022, In: ESC heart failure. 9, 2, p. 1239-1247 9 p.

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CT-derived fractional flow reserve (FFRct) for functional coronary artery evaluation in the follow-up of patients after heart transplantation

Budde, R. P. J., Nous, F. M. A., Roest, S., Constantinescu, A. A., Nieman, K., Brugts, J. J., Koweek, L. M., Hirsch, A., Leipsic, J. & Manintveld, O. C., Mar 2022, In: European Radiology. 32, 3, p. 1843-1852 10 p.

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10 Citations (Scopus)

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Endovascular renal sympathetic denervation to improve heart failure with reduced ejection fraction: the IMPROVE-HF-I study

Feyz, L., Nannan Panday, R., Henneman, M., Verzijlbergen, F., Constantinescu, A. A., van Dalen, B. M., Brugts, J. J., Caliskan, K., Geleijnse, M. L., Kardys, I., Van Mieghem, N. M., Manintveld, O. & Daemen, J., Mar 2022, In: Netherlands Heart Journal. 30, 3, p. 149-159 11 p.

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12 Citations (Scopus)

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Dynamic personalized risk prediction in chronic heart failure patients: a longitudinal, clinical investigation of 92 biomarkers (Bio-SHiFT study)

Klimczak-Tomaniak, D., de Bakker, M., Bouwens, E., Akkerhuis, K. M., Baart, S., Rizopoulos, D., Mouthaan, H., van Ramshorst, J., Germans, T., Constantinescu, A., Manintveld, O., Umans, V., Boersma, E. & Kardys, I., 18 Feb 2022, In: Scientific Reports. 12, 1, 2795.

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17 Citations (Scopus)

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2021

Evaluation of patients with a HeartMate 3 left ventricular assist device using echocardiographic particle image velocimetry

Schinkel, A. F. L., Akin, S., Strachinaru, M., Muslem, R., Bowen, D., Yalcin, Y. C., Brugts, J. J., Constantinescu, A. A., Manintveld, O. C. & Caliskan, K., Dec 2021, In: Journal of Ultrasound. 24, 4, p. 499-503 5 p.

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Clinical implementation of coronary computed tomography angiography for routine detection of cardiac allograft vasculopathy in heart transplant patients

Nous, F. M. A., Roest, S., van Dijkman, E. D., Attrach, M., Caliskan, K., Brugts, J. J., Nieman, K., Hirsch, A., Constantinescu, A. A., Manintveld, O. C. & Budde, R. P. J., Oct 2021, In: Transplant International. 34, 10, p. 1886-1894 9 p.

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16 Citations (Scopus)

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Personalized screening intervals for measurement of N-terminal pro-B-type natriuretic peptide improve efficiency of prognostication in patients with chronic heart failure

Schuurman, A. S., Tomer, A., Akkerhuis, K. M., Brugts, J. J., Constantinescu, A. A., Ramshorst, J. V., Umans, V. A., Boersma, E., Rizopoulos, D. & Kardys, I., 1 Sept 2021, In: European Journal of Preventive Cardiology. 28, 9, p. E11-E14

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6 Citations (Scopus)

Safety of Endomyocardial Biopsy in New-Onset Acute Heart Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation

Van Der Boon, R. M. A., Den Dekker, W. K., Meuwese, C. L., Lorusso, R., Von Der Thüsen, J. H., Constantinescu, A. C., Manintveld, O. C., Delnoij, T. S. R., Van Der Heijden, J. J., Van Mieghem, N. M. D. A. & Den Uil, C. A., Aug 2021, In: Circulation: Heart Failure. 14, 8, e008387.

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17 Citations (Scopus)

Sex-specific temporal evolution of circulating biomarkers in patients with chronic heart failure with reduced ejection fraction

Schreuder, M. M., Schuurman, A., Akkerhuis, K. M., Constantinescu, A. A., Caliskan, K., van Ramshorst, J., Germans, T., Umans, V. A., Boersma, E., Roeters van Lennep, J. E. & Kardys, I., 1 Jul 2021, In: International Journal of Cardiology. 334, p. 126-134 9 p.

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6 Citations (Scopus)

COVID-19-related myocarditis post-heart transplantation

Roest, S., Brugts, J. J., van Kampen, J. J. A., von der Thüsen, J. H., Constantinescu, A. A., Caliskan, K., Hirsch, A. & Manintveld, O. C., 1 Jun 2021, In: International Journal of Infectious Diseases. 107, p. 34-36 3 p.

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5 Citations (Scopus)

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Influence of renal insufficiency pre-heart transplantation on malignancy risk post-heart transplantation

Roest, S., Struijk, C., Constantinescu, A. A., Caliskan, K., Plasmeijer, E. I., Boersma, E., Brugts, J. J. & Manintveld, O. C., Jun 2021, In: ESC heart failure. 8, 3, p. 2172-2182 11 p.

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Left ventricular remodelling and prognosis after discharge in new-onset acute heart failure with reduced ejection fraction

van den Berge, J. C., Vroegindewey, M. M., Veenis, J. F., Brugts, J. J., Caliskan, K., Manintveld, O. C., Akkerhuis, K. M., Boersma, E., Deckers, J. W. & Constantinescu, A. A., 2 May 2021, In: ESC heart failure. 8, 4, p. 2679-2689 11 p.

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Concomitant endocarditis and spondylodiscitis due to coagulase-negative Staphylococci and a review of the literature

Houkes, K. M. G., Mudde, S. E., Constantinescu, A. A., Verkaik, N. J. & Yusuf, E., Jan 2021, In: IDCases. 24, e01100.

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2020

Temporal patterns of macrophage- and neutrophil-related markers are associated with clinical outcome in heart failure patients

Klimczak-Tomaniak, D., Bouwens, E., Schuurman, A. S., Akkerhuis, K. M., Constantinescu, A., Brugts, J., Westenbrink, B. D., van Ramshorst, J., Germans, T., Pączek, L., Umans, V., Boersma, E. & Kardys, I., 1 Jun 2020, In: ESC heart failure. 7, 3, p. 1190-1200 11 p.

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18 Citations (Scopus)

Impact of preoperative liver dysfunction on outcomes in patients with left ventricular assist devices

Yalcin, Y. C., Yalcin, Y. C., Muslem, R., Veen, K. M., Soliman, O. I., Manintveld, O. C., Darwish Murad, S., Kilic, A., Constantinescu, A. A., Brugts, J. J., Alkhunaizi, F., Birim, O., Tedford, R. J., Bogers, A. J. J. C., Hsu, S. & Caliskan, K., May 2020, In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 57, 5, p. 920-928 9 p.

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15 Citations (Scopus)

Incidence of end-stage renal disease after heart transplantation and effect of its treatment on survival

Roest, S., Hesselink, D., Tomaniak, M., Kardys, I., Caliskan, K., Brugts, J., Maat, A. P. W. M., Ciszek, M., Constantinescu, A. & Manintveld, O., 1 Apr 2020, In: ESC heart failure. 7, 2, p. 533-541 9 p.

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42 Citations (Scopus)

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Emerging electromagnetic interferences between implantable cardioverter-defibrillators and left ventricular assist devices

Yalcin, Y. C., Kooij, C., Theuns, D. A. M. J., Constantinescu, A. A., Brugts, J. J., Manintveld, O. C., Yap, S. C., Szili-Torok, T., Bogers, A. J. J. C. & Caliskan, K., Apr 2020, In: Europace. 22, 4, p. 584-587 4 p.

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26 Citations (Scopus)

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Impact of Continuous Flow Left Ventricular Assist Device Therapy on Chronic Kidney Disease: A Longitudinal Multicenter Study

Yalçin, Y., Muslem, R., Veen, K., Soliman, O., Hesselink, D., Constantinescu, A., Brugts, J., Manintveld, O., Fudim, M., Russell, S., Tomashitis, B., Houston, B., Hsu, S., Tedford, R., Bogers, A. & Caliskan, K., Apr 2020, In: Journal of Cardiac Failure. 26, 4, p. 333-341 9 p.

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27 Citations (Scopus)

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Aortic root thrombus after left ventricular assist device implantation and aortic valve replacement

Veenis, J., Brugts, J., Yalçin, Y., Roest, S., Bekkers, J., Manintveld, O., Constantinescu, A., Bogers, A., Zijlstra, F. & Caliskan, K., 2020, In: ESC heart failure. 7, 5, p. 3208-3212 5 p.

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5 Citations (Scopus)

Biatrial Versus Bicaval Orthotopic Heart Transplantation: A Systematic Review and Meta-Analysis

Zijderhand, C., Veen, K., Caliskan, K., Schoonen, T., Mokhles, M., Bekkers, J., Manintveld, O., Constantinescu, A., Brugts, J., Bogers, A. & Takkenberg, H., 2020, In: Annals of Thoracic Surgery. 110, 2, p. 684-691 8 p.

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21 Citations (Scopus)

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Mechanical Support in Early Cardiogenic Shock: What Is the Role of Intra-aortic Balloon Counterpulsation?

Kimman, J., van Mieghem, N., Endeman, R., Brugts, J., Constantinescu, A., Manintveld, O., Dubois, E. & Uil, C., 2020, In: Current Heart Failure Reports. 17, 5, p. 247-260 14 p.

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Monitoring pulmonary pressures during long-term continuous-flow left ventricular assist device and fixed pulmonary hypertension: redefining alleged pathophysiological mechanisms?

de Bakker, C., Veenis, J., Manintveld, O., Constantinescu, A., Caliskan, K., Uil, C. & Brugts, J., 2020, In: ESC heart failure. 7, 2, p. 702-704 3 p.

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Mycobacterium chelonae, an ‘atypical’ cause of an LVAD driveline infection

Roest, S., Bax, H., Verkaik, N., Brugts, J., Constantinescu, A., de Bakker, C., Birim, O., Caliskan, K. & Manintveld, O., 2020, In: International Journal of Infectious Diseases. 92, p. 127-129 3 p.

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Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio-SHiFT study)

Brankovic, M., Akkerhuis, M., Hoorn, E., van Boven, N., van den Berge, J.-K., Constantinescu, A., Brugts, J., van Ramshorst, J., Germans, T., Hillege, H., Boersma, E., Umans, V. & Kardys, I., 2020, In: Clinical Cardiology. 43, 6, p. 630-638 9 p.

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Survival following a concomitant aortic valve procedure during left ventricular assist device surgery: an ISHLT Mechanically Assisted Circulatory Support (IMACS) Registry analysis

Veenis, J., Yalçin, Y., Brugts, J., Constantinescu, A., Manintveld, O., Bekkers, J., Bogers, A. & Caliskan, K., 2020, In: European Journal of Heart Failure. 22, 10, p. 1878-1887 10 p.

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The Association Between Cytomegalovirus Infection and Cardiac Allograft Vasculopathy in the Era of Antiviral Valganciclovir Prophylaxis

Tomaniak, M., Roest, S., Brugts, J., Caliskan, K., Kardys, I., Zijlstra, F., Constantinescu, A., Kreeft - Voermans, J., van Kampen, J. & Manintveld, O., 2020, In: Transplantation. 104, 7, p. 1508-1518 11 p.

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Transcatheter closure and prognosis of coronary artery fistulae in heart transplant recipients

Constantinescu, A., Galli, G., Daemen, J., Brugts, J., van de Woestijne, P., Manintveld, O., van Mieghem, N. & Caliskan, K., 2020, In: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 16, 7, p. 600-602 3 p.

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2019

Acute Pump Thrombosis in the Early Postoperative Period After HeartMate 3 Implantation

Bunge, J., Uil, C., Constantinescu, A., Budde, R., Maat, A. P. W. M. & Caliskan, K., 2019, In: ASAIO Journal. 65, 7, p. E72-E74

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Design and rationale of haemodynamic guidance with CardioMEMS in patients with a left ventricular assist device: the HEMO-VAD pilot study

Veenis, J., Manintveld, O., Constantinescu, A., Caliskan, K., Birim, O., Bekkers, J., van Mieghem, N., Uil, C., Boersma, E., Lenzen, M., Zijlstra, F., Abraham, W., Adamson, P. & Brugts, J., 2019, In: ESC heart failure. 6, 1, p. 194-201 8 p.

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31 Citations (Scopus)

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Longitudinally Measured Fibrinolysis Factors are Strong Predictors of Clinical Outcome in Patients with Chronic Heart Failure: The Bio-SHiFT Study

Berg, V., Bouwens, E., Umans, V., de Maat, M., Manintveld, O., Caliskan, K., Constantinescu, A., Mouthaan, H., Cornel, J., Baart, S., Akkerhuis, M., Boersma, E. & Kardys, I., 2019, In: Thrombosis and Haemostasis. 119, 12, p. 1947-1955 9 p.

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17 Citations (Scopus)

Prediction of long-term (> 10year) cardiovascular outcomes in heart transplant recipients: Value of stress technetium-99m tetrofosmin myocardial perfusion imaging

Veenis, J., Boiten, H.-J., van den Berge, J.-K., Caliskan, K., Maat, A. P. W. M., Valkema, R., Constantinescu, A., Manintveld, O., Zijlstra, F., van Domburg, R. & Schinkel, A., 2019, In: Journal of Nuclear Cardiology. 26, 3, p. 845-852 8 p.

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11 Citations (Scopus)

Primary intra-aortic balloon support versus inotropes for decompensated heart failure and low output: a randomised trial

Uil, C., van Mieghem, N., Bastos, M., Jewbali, L., Lenzen, M., Engström, A., Bunge, J., Brugts, J., Manintveld, O., Daemen, J., Wilschut, J., Zijlstra, F. & Constantinescu, A., 2019, In: EuroIntervention. 15, 7, p. 586-+

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Repeated Echocardiograms Do Not Provide Incremental Prognostic Value to Single Echocardiographic Assessment in Minimally Symptomatic Patients with Chronic Heart Failure: Results of the Bio-SHiFT Study

Berg, V., Strachinaru, M., Alkerhuis, K., Baart, S., Brankovic, M., Constantinescu, A., Cornel, J., Manintveld, O., Umans, V., Rizopoulos, D., Geleijnse, M., Boersma, E., van Dalen, B. & Kardys, I., 2019, In: Journal of the American Society of Echocardiography. 32, 8, p. 1000-1009 10 p.

Research output: Contribution to journal › Article › Academic

9 Citations (Scopus)

dr. Alina Constantinescu

Research output

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