prof. dr. Anton W. Langerak

Search results

• 2022

  TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients

  Assmann, J. L. J. C., Kolijn, P. M., Schrijver, B., van Gammeren, A. J., Loth, D. W., Ermens, T. A. A. M., Dik, W. A., van der Velden, V. H. J. & Langerak, A. W., Jan 2022, In: Journal of Leukocyte Biology. 111, 1, p. 283-289 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • SARS Coronavirus 100%
  • Adaptive Immune System 25%
  • T Cell Receptor 25%
  4 Citations (Scopus)

  20 Downloads (Pure)
• 2021

  Treatment Approaches to Chronic Lymphocytic Leukemia With High-Risk Molecular Features

  van der Straten, L., Hengeveld, P. J., Kater, A. P., Langerak, A. W. & Levin, M. D., 9 Dec 2021, In: Frontiers in Oncology. 11, 780085.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

  File

  • Clinical Trial 100%
  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Chronic Lymphatic Leukemia 100%
  • Karyotype 50%
  • Cytogenetics 50%
  5 Citations (Scopus)

  35 Downloads (Pure)

• Assessment of the Clonal Dynamics of Acquired Mutations in Patients (Pts) with Relapsed/Refractory Chronic Lymphocytic Leukemia (R/R CLL) Treated in the Randomized Phase 3 Murano Trial Supports VenetoclaxRituximab (VenR) Fixed-Duration Combination Treatment (Tx)

  Seymour, J. F., Wu, J. Q., Popovic, R., Eichhorst, B., Hillmen, P., Kipps, T. J., Langerak, A. W., Owen, C., Dubois, J., Mellink, C., Van der Kevie-Kersemaekers, A.-M., Dunbar, F., Jiang, Y., Chyla, B., Boyer, M., Thadani-Mulero, M., Lefebure, M., Harrup, R. & Kater, A. P., 5 Nov 2021, In: Blood. 138, 7 p.

  Research output: Contribution to journal › Meeting Abstract › Academic › peer-review
  2 Citations (Web of Science)

• Multiple Immunoglobulin κ Gene Rearrangements within a Single Clone Unraveled by Next-Generation Sequencing–Based Clonality Assessment

  Leenders, A. M., Kroeze, L. I., Rijntjes, J., Luijks, J., Hebeda, K. M., Darzentas, N., Langerak, A. W., van den Brand, M. & Groenen, P. J. T. A., 1 Sept 2021, In: Journal of Molecular Diagnostics. 23, 9, p. 1097-1104 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Clonality 100%
  • Clonal Variation 100%
  • Gene Rearrangement 100%
  • Immunoglobulin Gene 100%
  • Cross Reaction 50%
  6 Citations (Scopus)

• Next-Generation Sequencing–Based Clonality Assessment of Ig Gene Rearrangements: A Multicenter Validation Study by EuroClonality-NGS

  EuroClonality-NGS Working Group, 1 Sept 2021, In: Journal of Molecular Diagnostics. 23, 9, p. 1105-1115 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Clonality 100%
  • Next Generation Sequencing 100%
  • Clonal Variation 100%
  • Gene Rearrangement 100%
  • Immunoglobulin Gene 100%
  26 Citations (Scopus)

• The variable biological signature of refractory cytopenia of childhood (RCC), a retrospective EWOG-MDS study

  de Winter, D. T. C., Langerak, A. W., te Marvelde, J., Dworzak, M. N., De Moerloose, B., Starý, J., Locatelli, F., Hasle, H., de Vries, A. C. H., Schmugge, M., Niemeyer, C. M., van den Heuvel-Eibrink, M. M. & van der Velden, V. H. J., 1 Sept 2021, In: Leukemia Research. 108, 106652.

  Research output: Contribution to journal › Article › Professional › peer-review
  2 Citations (Scopus)

• Anti-trbc1 antibody-based flow cytometric detection of t-cell clonality: Standardization of sample preparation and diagnostic implementation

  Muñoz-García, N., Lima, M., Villamor, N., Morán-Plata, F. J., Barrena, S., Mateos, S., Caldas, C., Balanzategui, A., Alcoceba, M., Domínguez, A., Gómez, F., Langerak, A. W., van Dongen, J. J. M., Orfao, A. & Almeida, J., 30 Aug 2021, In: Cancers. 13, 17, 4379.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Clonality 100%
  • Clonal Variation 100%
  • T Cell 100%
  • T Cell Receptor 11%
  19 Citations (Scopus)

  280 Downloads (Pure)

• Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia

  Kolijn, P. M., Muggen, A. F., Ljungström, V., Agathangelidis, A., Wolvers-Tettero, I. L. M., Beverloo, H. B., Pál, K., Hengeveld, P. J., Darzentas, N., Hendriks, R. W., Dongen, J. J. M. V., Rosenquist, R. & Langerak, A. W., 26 Aug 2021, In: Frontiers in Oncology. 11, 740083.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intravenous Immunoglobulin 100%
  • B-Cell Receptor 100%
  • IGHV@ 100%
  • Immunoglobulin 100%
  • B Lymphocyte Receptor 100%
  4 Citations (Scopus)

  144 Downloads (Pure)

• Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

  Stewart, J. P., Gazdova, J., Darzentas, N., Wren, D., Proszek, P., Fazio, G., Songia, S., Alcoceba, M., Sarasquete, M. E., Villarese, P., Van Der Klift, M. Y., Heezen, K. C., McCafferty, N., Pal, K., Catherwood, M., Kim, C. S., Srivastava, S., Kroeze, L. I., Hodges, E. & Stamatopoulos, K. & 14 others, Klapper, W., Genuardi, E., Ferrero, S., Van Den Brand, M., Cazzaniga, G., Davi, F., Sutton, L. A., Garcia-Sanz, R., Groenen, P. J. T. A., Macintyre, E. A., Bruggemann, M., Pott, C., Langerak, A. W. & Gonzalez, D., 24 Aug 2021, In: Blood advances. 5, 16, p. 3188-3198 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Next Generation Sequencing 100%
  • Clonality 66%
  • Clonal Variation 66%
  • B Cell 66%
  • T Cell 66%
  33 Citations (Scopus)

• Adult-Onset Autoimmune Enteropathy in an European Tertiary Referral Center

  van Wanrooij, R. L. J., Neefjes-Borst, E. A., Bontkes, H. J., Schreurs, M. W. J., Langerak, A. W., Mulder, C. J. J. & Bouma, G., 1 Aug 2021, In: Clinical and Translational Gastroenterology. 12, 8, p. e00387

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Enteropathy 100%
  • Patient Referral 100%
  • Autoimmune Enteropathy 100%
  • Coeliac Disease 57%
  • Monospecific Antibody 42%
  7 Citations (Scopus)

• Transitioning From T-Cell Clonality Testing to High-Throughput Sequencing

  Greiner, T. C., Bagg, A. & Langerak, A. W., 1 Jul 2021, In: Journal of Molecular Diagnostics. 23, 7, p. 781-783 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• B-cell receptor stereotyped subsets and outcome for patients with chronic lymphocytic leukemia in the HOVON 68 trial

  HOVON 68 trial group, 8 Jun 2021, In: Journal of Translational Genetics and Genomics (JTGG). 5, 2, p. 182-188

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Progression Free Survival 100%
  • B-Cell Receptor 100%
  • IGHV@ 100%
  • Chronic Lymphatic Leukemia 100%
  • B Lymphocyte Receptor 100%
  40 Downloads (Pure)

• Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

  ERIC, the European Research Initiative on CLL, Agathangelidis, A., Chatzidimitriou, A., Gemenetzi, K., Giudicelli, V., Karypidou, M., Plevova, K., Davis, Z., Yan, X. J., Jeromin, S., Schneider, C., Pedersen, L. B., Tschumper, R. C., Sutton, L. A., Baliakas, P., Scarfò, L., van Gastel, E. J., Armand, M., Tausch, E. & Biderman, B. & 31 others, Baer, C., Bagnara, D., Navarro, A., Langlois de Septenville, A., Guido, V., Mitterbauer-Hohendanner, G., Dimovski, A., Brieghel, C., Lawless, S., Meggendorfer, M., Brazdilova, K., Ritgen, M., Facco, M., Tresoldi, C., Visentin, A., Patriarca, A., Catherwood, M., Bonello, L., Sudarikov, A., Vanura, K., Roumelioti, M., Skuhrova Francova, H., Moysiadis, T., Veronese, S., Giannopoulos, K., Mansouri, L., Karan-Djurasevic, T., Sandaltzopoulos, R., Bödör, C., Fischer, K. & Langerak, A. W., 11 Mar 2021, In: Blood. 137, 10, p. 1365-1376 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Patient Coding 100%
  • B-Cell Receptor 100%
  • Stereotypy 75%
  • Intravenous Immunoglobulin 50%
  • IGHV@ 50%
  82 Citations (Scopus)

• Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study

  EuroMRD, EuroClonality-NGS Working Group, van der Velden, V. H. J., Brueggemann, M., Cazzaniga, G., Scheijen, B., Tops, B., Trka, J., Pal, K., Haenzelmann, S., Fazio, G., Songia, S., Langerak, A. W. & Darzentas, N., Mar 2021, In: Leukemia. 35, 3, p. 924-928 5 p.

  Research output: Contribution to journal › Article › Professional › peer-review

  Open Access

  File
  4 Citations (Scopus)

  17 Downloads (Pure)

• Voor het eerst Nederlandse SCID-patiënt geidentificeerd met de hielprikscreening

  Translated title of the contribution: SCID patient in the Netherlands identified for the first time via newborn screeningBlom, M., Berghuis, D., Vermont, C., Kemper, E. A., Weijman, G., Dekkers, E. H. B. M., Dik, W., Hollink, I., Langerak, T., Bredius, R. G. M. & van der Burg, M., Feb 2021, In: Nederlands Tijdschrift voor Allergie, Astma en Klinische Immunologie. 21, 1, 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • T Cell 100%
  • Receptor 100%
  • Eicosanoid Receptor 100%
  • Newborn Screening 100%
  • Severe Combined Immunodeficiency 100%

• Protein functionality as a potential bottleneck for somatic revertant variants

  Kaiser, F., Reisli, I., Knijnenburg, I., Langerak, T., Kavelaars, F., Artac, H., Ijspeert, H. & van der Burg, M., Jan 2021, In: Journal of Allergy and Clinical Immunology. 147, 1, p. 391-393.e8

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  3 Citations (Scopus)

  19 Downloads (Pure)

• Reading the B-cell receptor immunome in chronic lymphocytic leukemia: revelations and applications

  Hengeveld, P., Levin, M., Kolijn, M. & Langerak, T., Jan 2021, In: Experimental Hematology. 93, p. 14-24 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • B Lymphocyte Receptor 100%
  • B-Cell Chronic Lymphocytic Leukemia 100%
  • B-Cell Receptor 100%
  • IGHV@ 28%
  • Diseases 14%
  10 Citations (Scopus)

  27 Downloads (Pure)
• 2020

  Extensive longitudinal immune profiling reveals sustained innate immune activaton in COVID-19 patients with unfavorable outcome

  Schrijver, B., Assmann, J. L. J. C., van Gammeren, A. J., Vermeulen, R. C. H., Portengen, L., Heukels, P., Langerak, A. W., Dik, W. A., van der Velden, V. H. J. & Ermens, T. A. A. M., Dec 2020, In: European Cytokine Network. 31, 4, p. 154-167 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Interleukin-6 100%
  • SARS Coronavirus 100%
  • CXCL10 100%
  • Leukocyte 100%
  • Cytokine 100%
  8 Citations (Scopus)

  20 Downloads (Pure)

• Immunoglobulin heavy variable somatic hyper mutation status in chronic lymphocytic leukaemia: on the threshold of a new era?

  Langerak, A. W., Davi, F. & Stamatopoulos, K., 1 Jun 2020, In: British Journal of Haematology. 189, 5, p. 809-810 2 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access
  7 Citations (Scopus)

• Gas Geven of Remmen? Immuunmonitoring Als Basis Voor Immuuntherapie

  Hamann, D., Damoiseaux, J., Langerak, T., van Lochem, E. & Otten, H., Feb 2020, In: Nederlands Tijdschrift voor Allergie, Astma en Klinische Immunologie. 20, 1, p. 24-28

  Research output: Contribution to journal › Comment/Letter to the editor › Professional

• A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation

  Betjes, M. G. H., Langerak, T., Klepper, M. & Litjens, N., 2020, In: Immunity and Ageing. 17, 1, 4.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  18 Citations (Scopus)

  20 Downloads (Pure)

• Blood cell counts and lymphocyte subsets of patients admitted during the COVID-19 pandemic: a prospective cohort study

  Hengeveld, P., Khader, A., de Bruin, L., Geelen, I., van Baalen, E., Jansen, E., Bouwer, N., Balak, O., Riedl, J., Langerak, T., Westerweel, P. & Levin, M., 2020, In: British Journal of Haematology. 190, 4, p. E201-E204

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  10 Citations (Scopus)

  19 Downloads (Pure)

• Diagnostiek Van Primaire Immunodeficiënties

  Dik, W. & Langerak, T., 2020, Handboek Medische laboratoriumdiagnostiek. Houten, p. 611-616

  Research output: Chapter/Conference proceeding › Chapter › Professional

• IGHV somatic hypermutation status in CLL: on the threshold of a new era

  Langerak, A. W., Davi, F. & Stamatopoulos, K., 2020, In: British Journal of Haematology. 189, p. 809-810

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

• Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing

  Davi, F., Langerak, T., de Septenville, A., Kolijn, M., Hengeveld, P., Chatzidimitriou, A., Bonfiglio, S., Sutton, L., Rosenquist, R., Ghia, P. & Stamatopoulos, K., 2020, In: Leukemia. 34, 10, p. 2545-2551 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  26 Citations (Scopus)

  15 Downloads (Pure)

• Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

  Saberi Hosnijeh, F., Kolijn, M., Casabonne, D., Nieters, A., Solans, M., Naudin, S., Ferrari, P., Mckay, J., Weiderpass, E., Perduca, V., Besson, C., Mancini, F., Masala, G., Krogh, V., Ricceri, F., Huerta, J., Petrova, D., Sala, N., Trichopoulou, A. & Karakatsani, A. & 10 others, La Vecchia, C., Kaaks, R., Canzian, F., Aune, D., Boeing, H., Schulze, M., Perez-Cornago, A., Langerak, T., van der Velden, V. & Vermeulen, R., 2020, In: Scientific Reports. 10, 1, 13814.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  16 Downloads (Pure)

• Memento for interprofessional learning

  Groenen, P., Langerak, T., Fend, F. & Van Krieken, J., 2020, In: Virchows Archiv. 477, 5, p. 755-756 2 p.

  Research output: Contribution to journal › Article › Academic

  Open Access

  File
  1 Citation (Scopus)

  15 Downloads (Pure)

• Moleculaire klonaliteitsdiagnostiek van lymfoproliferaties

  Langerak, T., 2020, Handboek Medische laboratoriumdiagnostiek. Houten, p. 533-536

  Research output: Chapter/Conference proceeding › Chapter › Professional

• Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival

  Pal Singh, S., Bruijn, M., Graca, C., Corneth, O., Rip, J., Stadhouders, R., Meijers, R., Schurmans, S., Kerr, W., Burg, J., Eldering, E., Langerak, T., Pillai, S. & Hendriks, R., 2020, In: Journal of Immunology. 204, 2, p. 360-374 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study

  Saberi Hosnijeh, F., van der Straten, L., Kater, A., van Oers, M., Posthuma, W., Chamuleau, M., Bellido, M., Doorduijn, J., Gelder, M., Hoogendoorn, M., Boer, F., te Raa, G., Kerst, J., Marijt, E., Raymakers, R., Koene, H., Schaafsma, M., Dobber, J., Tonino, S. & Kersting, S. & 2 others, Langerak, T. & Levin, M., 2020, In: Experimental Hematology. 89, p. 55-60.e6

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  14 Downloads (Pure)

• Rapid Low-Cost Microarray-Based Genotyping for Genetic Screening in Primary Immunodeficiency

  Suratannon, N., Wijck, R., Broer, L., Xue, M., Meurs, J., Barendregt, B., Burg, M., Dik, W., Chatchatee, P., Langerak, T., Swagemakers, S., Goos, J., Mathijssen, I., Dalm, V., Suphapeetiporn, K., Heezen, K., Drabwell, J., Uitterlinden, A., Spek, P. & Hagen, P., 2020, In: Frontiers in Immunology. 11, 614.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  20 Citations (Scopus)

  7 Downloads (Pure)

• Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-kappa B pathway

  Meijers, R., Muggen, A., Gonzalez Leon, L., de Bie, M., Dongen, J., Hendriks, R. & Langerak, T., 2020, In: Haematologica. 105, 1, p. 182-192 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  14 Downloads (Pure)

• Validation of a Combined Transcriptome and T Cell Receptor Alpha/Beta (TRA/TRB) Repertoire Assay at the Single Cell Level for Paucicellular Samples

  Litjens, N., Langerak, T., van der List, A., Klepper, M., de Bie, M., Azmani, Z., den Dekker, X., Brouwer, R., Betjes, M. G. H. & van Ijcken, W., 2020, In: Frontiers in Immunology. 11, 1999.

  Research output: Contribution to journal › Article › Academic

  Open Access

  File
  2 Citations (Scopus)

  40 Downloads (Pure)
• 2019

  “Large Granular Lymphocyte” (Lgl) Leukemia / grootkorrelige lymfocytenleukemie: richtlijnen voor diagnostiek en behandeling

  Sandberg, Y., Langerak, T. & Doorduijn, J. K., Oct 2019, In: Nederlands Tijdschrift voor Hematologie. 16, 7, p. 349-356 8 p.

  Research output: Contribution to journal › Article › Professional

• A New and Simple TRG Multiplex PCR Assay for Assessment of T-cell Clonality: A Comparative Study from the EuroClonality Consortium

  Armand, M., Derrieux, C., Beldjord, K., Wabeke, T., Lenze, D., Boone, E., Bruggemann, M., Evans, P., Gameiro, P., Hummel, M., Villarese, P., Groenen, P., Langerak, T., Macintyre, E. & Davi, F., 2019, In: HemaSphere. 3, 3, UNSP e255.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  11 Citations (Scopus)

  66 Downloads (Pure)

• An Intraocular Inflammatory Profile of Rubella Associated Uveitis

  Fazil, Z., ten Berge, J., Langerak, T., Rothova, A. & Dik, W., 2019, In: Ocular Immunology and Inflammation. 27, 3, p. 418-423 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  10 Citations (Scopus)

  14 Downloads (Pure)

• Blood monitoring of circulating tumor plasma cells by next generation flow in multiple myeloma after therapy

  Sanoja-Flores, L., Flores-Montero, J., Puig, N., Contreras-Sanfeliciano, T., Pontes, R., Corral-Mateos, A., van der Velden, V., Langerak, T., te Marvelde, J., Vermeulen, J., Heezen, K., Dongen, J. & Orfao, A., 2019, In: Blood. 134, p. 2218-2222 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  72 Citations (Scopus)

• Combined cellular and soluble mediator analysis for improved diagnosis of vitreoretinal lymphoma

  Hoog, J., Dik, W., Lu, L., Heezen, K., Berge, J., Swagemakers, S., van der Spek, P., van Dongen, J., van der Velden, V., Rothova, A. & Langerak, T., 2019, In: Acta Ophthalmologica. 97, 6, p. 626-632 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)

• Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction

  Kurtz, D., Esfahani, M., Scherer, F., Soo, J., Jin, M., Liu, C., Newman, A., Duhrsen, U., Huttmann, A., Casasnovas, O., Westin, J., Ritgen, M., Bottcher, S., Langerak, T., Roschewski, M., Wilson, W., Gaidano, G., Rossi, D., Bahlo, J. & Hallek, M. & 3 others, Tibshirani, R., Diehn, M. & Alizadeh, A., 2019, In: Cell. 178, 3, p. 699-+

  Research output: Contribution to journal › Article › Academic › peer-review
  142 Citations (Scopus)

• Fixed Duration of Venetoclax-Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Eradicates Minimal Residual Disease and Prolongs Survival: Post-Treatment Follow-Up of the MURANO Phase III Study

  Kater, A., Seymour, J., Hillmen, P., Eichhorst, B., Langerak, T., Owen, C., Verdugo, M., Wu, J., Punnoose, E., Jiang, Y., Wang, J., Boyer, M., Humphrey, K., Mobasher, M. & Kipps, T., 2019, In: Journal of Clinical Oncology. 37, 4, p. 269-+

  Research output: Contribution to journal › Article › Academic › peer-review
  251 Citations (Scopus)

• Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS

  Scheijen, B., Meijers, R., Rijntjes, J., Klift, M., Mobs, M., Steinhilber, J., Reigl, T., Brand, M., Kotrova, M., Ritter, J., Catherwood, M., Stamatopoulos, K., Bruggemann, M., Davi, F., Darzentas, N., Pott, C., Fend, F., Hummel, M., Langerak, T. & Groenen, P., 2019, In: Leukemia. 33, 9, p. 2227-2240 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  88 Citations (Scopus)

  20 Downloads (Pure)

• PCR GeneScan and Heteroduplex Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes for Clonality Diagnostics in Suspect Lymphoproliferations

  Boone, E., Heezen, K., Groenen, P. & Langerak, T., 2019, In: Methods in Molecular Biology. 1956, p. 77-103 27 p.

  Research output: Contribution to journal › Article › Academic
  5 Citations (Scopus)

• Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab

  Langerak, T., Ritgen, M., Goede, V., Robrecht, S., Bahlo, J., Fischer, K., Steurer, M., Trneny, M., Mulligan, S., Mey, U., Trunzer, K., Fingerle-Rowson, G., Humphrey, K., Stilgenbauer, S., Bottcher, S., Bruggemann, M., Hallek, M., Kneba, M. & Dongen, J., 2019, In: Blood. 133, 5, p. 494-497 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)

• Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

  Knecht, H., Reigl, T., Kotrova, M., Appelt, F., Stewart, P., Bystry, V., Krejci, A., Grioni, A., van der Pal, K., Stranska, K., Plevova, K., Rijntjes, J., Songia, S., Svaton, M., Fronkova, E., Bartram, J., Scheijen, B., Herrmann, D., Garcia-Sanz, R. & Hancock, J. & 14 others, Moppett, J., van Dongen, J., Cazzaniga, G., Davi, F., Groenen, P., Hummel, M., Macintyre, E., Stamatopoulos, K., Trka, J., Langerak, T., Gonzalez, D., Pott, C., Bruggemann, M. & Darzentas, N., 2019, In: Leukemia. 33, 9, p. 2254-2265 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  68 Citations (Scopus)

  21 Downloads (Pure)

• Quantitative Analysis of Minimal Residual Disease (MRD) Shows High Rates of Undetectable MRD after Fixed-Duration Chemotherapy-Free Treatment and Serves As Surrogate Marker for Progression-Free Survival: A Prospective Analysis of the Randomized CLL14 Trial

  Fischer, K., Ritgen, M., Al-Sawaf, O., Robrecht, S., Tandon, M., Fink, A. M., Schilhabel, A., Stübig, T., Brüggemann, M., Jiang, Y., Schary, W., Eichhorst, B., Wendtner, C., Tausch, E., Kreuzer, K., Langerak, T., Goede, V., Böttcher, S., Stilgenbauer, S. & Kneba, M. & 1 others, Hallek, M., 2019, In: Blood. 134, 1, p. 36

  Research output: Contribution to journal › Article › Academic › peer-review

• Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

  Bruggemann, M., Kotrova, M., Knecht, H., Bartram, J., Boudjogrha, M., Bystry, V., Fazio, G., Fronkova, E., Giraud, M., Grioni, A., Hancock, J., Herrmann, D., Jimenez, C., Krejci, A., Moppett, J., Reigl, T., Salson, M., Scheijen, B., Schwarz, M. & Songia, S. & 17 others, Svaton, M., van Dongen, J., Villarese, P., Wakeman, S., Wright, G., Cazzaniga, G., Davi, F., Garcia-Sanz, R., Gonzalez, D., Groenen, P., Hummel, M., Macintyre, E., Stamatopoulos, K., Pott, C., Trka, J., Darzentas, N. & Langerak, T., 2019, In: Leukemia. 33, 9, p. 2241-2253 13 p.

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  176 Citations (Scopus)

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• The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

  Muggen, A., Jong, M., Tettero, I., Kallemeijn, M., Goncalves Grunho Teodosio, C., Darzentas, N., Stadhouders, R., Ijspeert, H., van der Burg, M., van Ijcken, W., Verhaar, J., Abdulahad, W., Brouwer, E., Boots, A., Hendriks, R., Dongen, J. & Langerak, T., 2019, In: Immunity and Ageing. 16, 1, 22.

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• Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

  Fischer, K., Al-Sawaf, O., Bahlo, J., Fink, A. M., Tandon, M., Dixon, M., Langerak, T., Mobasher, M. & Hallek, M., 2019, In: New England Journal of Medicine. 380, 23, p. 2225-2236 12 p.

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  627 Citations (Scopus)
• 2018

  A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL

  Dimier, N., Delmar, P., Ward, C., Morariu-Zamfir, R., Fingerle-Rowson, G., Bahlo, J., Fischer, K., Eichhorst, B., Goede, V., Dongen, J., Ritgen, M., Bottcher, S., Langerak, T., Kneba, M. & Hallek, M., 2018, In: Blood. 131, 9, p. 955-962 8 p.

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  65 Citations (Scopus)

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• Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS

  Goeje, P., Klaver, Y., Lambers, M., Langerak, T., Vroman, H., Kunert, A., Lamers, C., Aerts, J., Debets, R. & Hendriks, R., 2018, In: Frontiers in Immunology. 9, 2034.

  Research output: Contribution to journal › Article › Academic
  12 Citations (Scopus)