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Personal profile

Research interests

Understanding leukemia predisposition syndromes

As PI/assistant Professor in the department of Hematology, my research program focusses on questions regarding the role of Gata2 and more general of germline mutations that predispose to the development of acute myeloid leukemia (AML). We have built zebrafish disease models recapitulating patient characteristics and we answer our research questions using a variety of human, mouse and zebrafish models. We have identified several roles for GATA2 in hematopoiesis and uncovered that GATA2 is required for proper HSC proliferation, potentially contributing to malignant transformation. We investigate the contribution of perturbation in embryonic hematopoietic development to leukemia development using intricate inducible genetic zebrafish models. My current work focusses on uncovering changes in protein and DNA binding of GATA2 with patient specific zinc finger mutations.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Growth of the zebrafish heart, Utrecht University

1 Dec 200515 Feb 2010

Award Date: 3 Jun 2010

Master, Biology, Leiden University

21 Sept 200030 Sept 2005

Award Date: 30 Sept 2005

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Collaborations and top research areas from the last five years

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