Research output per year
Research output per year
Personal profile
Research interests
Understanding leukemia predisposition syndromes
As PI/assistant Professor in the department of Hematology, my research program focusses on questions regarding the role of Gata2 and more general of germline mutations that predispose to the development of acute myeloid leukemia (AML). We have built zebrafish disease models recapitulating patient characteristics and we answer our research questions using a variety of human, mouse and zebrafish models. We have identified several roles for GATA2 in hematopoiesis and uncovered that GATA2 is required for proper HSC proliferation, potentially contributing to malignant transformation. We investigate the contribution of perturbation in embryonic hematopoietic development to leukemia development using intricate inducible genetic zebrafish models. My current work focusses on uncovering changes in protein and DNA binding of GATA2 with patient specific zinc finger mutations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Growth of the zebrafish heart, Utrecht University
1 Dec 2005 → 15 Feb 2010
Award Date: 3 Jun 2010
Master, Biology, Leiden University
21 Sept 2000 → 30 Sept 2005
Award Date: 30 Sept 2005
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
Koyunlar, C., Gioacchino, E., Vadgama, D., de Looper, H. W. J., Zink, J., Ter Borg, M., Hoogenboezem, R., Havermans, M., Sanders, M. A., Bindels, E., Dzierzak, E. A., Touw, I. P. & de Pater, E., 23 May 2023, In: Blood advances. 7, 10, p. 2082-2093 12 p.Research output: Contribution to journal › Article › Academic › peer-review
2 Citations (Scopus) -
Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish
Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H., de Jong, M., Dobrzycki, T., Mahony, C. B., Hoogenboezem, R., Bosch, D., van Strien, P. M. H., van Royen, M. E., French, P. J., Bindels, E., Gussinklo, K. J., Monteiro, R., Touw, I. P. & de Pater, E., 25 Jun 2021, In: Blood advances. 5, 13, p. 2687-2700 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Citations (Scopus)20 Downloads (Pure) -
Gata2 is required for HSC generation and survival
De Pater, E., Kaimakis, P., Vink, C., Yokomizo, T., Yamada-Inagawa, T., Linden, R., Solaimani Kartalaei, P., Camper, S., Speck, N. & Dzierzak, E., 2013, In: Journal of Experimental Medicine. 210, 13, p. 2843-2850 8 p.Research output: Contribution to journal › Article › Academic › peer-review
182 Citations (Scopus) -
Bloody Zebrafish: Novel Methods in Normal and Malignant Hematopoiesis
De Pater, E. & Trompouki, E., 2018, In: Frontiers in Cell and Developmental Biology. 6, Unsp 124.Research output: Contribution to journal › Article › Academic
Open AccessFile10 Citations (Scopus)36 Downloads (Pure) -
Stem Cells and Haemopoiesis
De Pater, E. & Dzierzak, E., 6 Nov 2015, Postgraduate Haematology: Seventh Edition. Wiley-Blackwell, p. 1-10 10 p.Research output: Chapter/Conference proceeding › Chapter › Academic
Prizes
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Timing and function of Gata2 haploinsufficiency
De Pater, E. (Recipient), 9 Jul 2022
Prize: Fellowship awarded competitively
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Binding partners of GATA2
De Pater, E. (Recipient), 18 Nov 2021
Prize: Fellowship awarded competitively
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Role of GATA2-controlled programs in the genetic predisposition to acute leukemia
De Pater, E. (Recipient), 14 Dec 2016
Prize: Fellowship awarded competitively
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The role of Tmem2 in EHT regulation
De Pater, E. (Recipient), 9 Jan 2015
Prize: Fellowship awarded competitively