dr. Evert-Jan Wils

Search results

• 2025

  Long-Term multidimensional patient-centred outcomes after hospitalisation for COVID-19: Do not only focus on disease severity

  Bek, M., Türk, Y., Janssen, M. L., Weijsters, G., Berentschot, J. C., Van Den Berg-Emons, R. J. G., Heijenbrok-Kal, M. H., Ribbers, G. M., Aerts, J., Hanselaar, W. E. J. J., Endeman, H., Hellemons, M. E. & Wils, E. J., 8 Jun 2025, In: BMJ Open Respiratory Research. 12, 1, e002789.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Disease Severity 100%
  • COVID-19 100%
  • Quality of Life 80%
  • Artificial Respiration 40%
  • Oxygen Therapy 40%
  7 Downloads (Pure)

• Early versus Delayed Switching from Controlled to Assisted Ventilation A Target Trial Emulation

  Reep, C. A. T., Wils, E. J., Fleuren, L. M., Breskin, A., Bellani, G., Laffey, J. G., Brochard, L. J., Pham, T. & Heunks, L., Jun 2025, In: American Journal of Respiratory and Critical Care Medicine. 211, 6, p. 975-983 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Assisted Ventilation 100%
  • Artificial Respiration 80%
  • Cumulative Incidence 60%
  • Extubation 40%
  • Mortality Rate 20%
  1 Citation (Scopus)

• The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome

  Groenland, C. N. L., Siemers, A. H., Dubois, E. A., Gommers, D., Heunks, L., Wils, E. J., Baggen, V. J. M. & Endeman, H., 9 Jan 2025, In: Annals of Intensive Care. 15, 1, 2.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Biological Marker 100%
  • Troponin T 100%
  • Adult Respiratory Distress Syndrome 100%
  • Extubation 100%
  • Procalcitonin 62%
  21 Downloads (Pure)
• 2024

  Reporting Guidelines for the Early-Phase Clinical Evaluation of Applications Using Extended Reality: RATE-XR Qualitative Study Guideline

  Vlake, J. H., Drop, D. L. Q., RATE-XR Expert Group, Van Bommel, J., Riva, G., Wiederhold, B. K., Cipresso, P., Rizzo, A. S., Rothbaum, B. O., Botella, C., Hooft, L., Bienvenu, O. J., Jung, C., Geerts, B., Wils, E. J., Gommers, D. & van Genderen, M. E., 29 Nov 2024, In: Journal of Medical Internet Research. 26, 1, e56790.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Health Care 100%
  • Extended Reality 100%
  • Clinical Trial 100%
  • Checklist 66%
  • Virtual Reality 33%
  1 Citation (Scopus)

  32 Downloads (Pure)

• DeltaScan for the Assessment of Acute Encephalopathy and Delirium in ICU and non-ICU Patients, a Prospective Cross-Sectional Multicenter Validation Study: Fienke L. Ditzel, MD. e-mail: [email protected]

  Ditzel, F. L., Hut, S. C. A., van den Boogaard, M., Boonstra, M., Leijten, F. S. S., Wils, E. J., van Nesselrooij, T., Kromkamp, M., Rood, P. J. T., Röder, C., Bouvy, P. F., Coesmans, M., Osse, R. J., Pop-Purceleanu, M., van Dellen, E., Krulder, J. W. M., Milisen, K., Faaij, R., Vondeling, A. M. & Kamper, A. M. & 12 others, van Munster, B. C., de Jonghe, A., Winters, M. A. M., van der Ploeg, J., van der Zwaag, S., Koek, D. H. L., Drenth-van Maanen, C. A. C., Beishuizen, A., van den Bos, D. M., Cahn, W., Schuit, E. & Slooter, A. J. C., Sept 2024, In: American Journal of Geriatric Psychiatry. 32, 9, p. 1093-1104 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intensive Care Unit 100%
  • Delirium 100%
  • Acute Brain Disease 100%
  • Brain Disease 100%
  • Validation Study 100%
  4 Citations (Scopus)

  31 Downloads (Pure)

• Racial Disparities in Pulse Oximetry, in COVID-19 and ICU Settings

  Reep, C. A. T., Fleuren, L. M., on behalf of the National COVID Cohort Collaborative Consortium, Heunks, L. & Wils, E. J., Aug 2024, In: Critical Care Explorations. 6, 8, e1132.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hypoxemia 100%
  • Pulse Oximetry 100%
  • Racial Disparity 100%
  • COVID-19 100%
  • Racial Group 40%
  2 Citations (Scopus)

  12 Downloads (Pure)

• At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

  Mesinovic, M., Wong, X. C., Rajahram, G. S., Citarella, B. W., Peariasamy, K. M., van Someren Greve, F., Olliaro, P., Merson, L., Clifton, L., Kartsonaki, C. & ISARIC Characterisation Group, 16 Jul 2024, In: Scientific Reports. 14, 1, 16387.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Pulmonary Embolism 100%
  • COVID-19 100%
  • Lung Embolism 100%
  • Dyspnea 28%
  • Decision Making 14%
  1 Citation (Scopus)

  17 Downloads (Pure)

• Safety and Outcome of High-Flow Nasal Oxygen Therapy Outside ICU Setting in Hypoxemic Patients With COVID-19∗

  the Dutch HFNO COVID-19 Study Group, Janssen, M. L., Türk, Y., Baart, S. J., Hanselaar, W., Aga, Y., Van Der Steen-Dieperink, M., Van Der Wal, F. J., Versluijs, V. J., Hoek, R. A. S., Endeman, H., Boer, D. P., Hoiting, O., Hoelters, J., Achterberg, S., Stads, S., Heller-Baan, R., Dubois, A. V. F., Elderman, J. H. & Wils, E. J. & 6 others, Gajadin, S., Cox, L., Grewal, S., Van Oosten, J., Vlasveld, I. N. & Jacobs, W., 1 Jan 2024, In: Critical Care Medicine. 52, 1, p. 31-43 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Oxygen Therapy 100%
  • COVID-19 100%
  • Mortality Rate 100%
  • Intubation 100%
  • Respiratory Failure 50%
  13 Citations (Scopus)

  80 Downloads (Pure)
• 2023

  Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19

  Camirand-Lemyre, F., Merson, L., Vijayaraghavan, B. K. T., ISARIC Clinical Characterization Group, Burrell, A. J. C., Citarella, B. W., Domingue, M.-P., Levesque, S., Usuf, E., Wils, E.-J., Ohshimo, S., Martin-Loeches, I., Sandulescu, O., Laake, J. H. & Lamontagne, F., 26 Dec 2023, In: JAMA network open. 6, 12, p. E2346502 11 p., e2346502.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Infection 100%
  • Clinical Trial 60%
  • Cohort Study 20%
  • Prospective Cohort Study 20%
  • Geographic Distribution 20%
  6 Citations (Scopus)

  13 Downloads (Pure)

• Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients

  Janssen, M. L., Jonkman, A. H., Wennen, M., Wils, E. J., Endeman, H. & Heunks, L., Dec 2023, In: Intensive Care Medicine Experimental. 11, 1, 73.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Breathing 100%
  • Tidal Volume 100%
  • Diaphragm 100%
  • Confidence Interval 100%
  • Volunteer 36%
  4 Citations (Scopus)

  24 Downloads (Pure)

• Airborne virus shedding of the alpha, delta, omicron SARS-CoV-2 variants and influenza virus in hospitalized patients

  Ong, D. S. Y., de Man, P., Verhagen, T., Doejaaren, G., Dallinga, M. A., Alibux, E., Janssen, M. L. & Wils, E. J., Apr 2023, In: Journal of Medical Virology. 95, 4, e28748.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Viral Shedding 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Omicron Coronavirus Variant 100%
  • Influenza Virus 100%
  • Airborne Virus 100%
  5 Citations (Scopus)

  33 Downloads (Pure)
• 2022

  Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial

  Ewoldt, T. M. J., Abdulla, A., Rietdijk, W. J. R., Muller, A. E., de Winter, B. C. M., Hunfeld, N. G. M., Purmer, I. M., van Vliet, P., Wils, E.-J., Haringman, J., Draisma, A., Rijpstra, T. A., Karakus, A., Gommers, D., Endeman, H. & Koch, B. C. P., Dec 2022, In: Intensive Care Medicine. 48, 12, p. 1760-1771 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Randomized Clinical Trial 100%
  • Ciprofloxacin 100%
  • Beta Lactam Antibiotic 100%
  • Pharmacometrics 25%
  • Antibiotics 25%
  73 Citations (Scopus)

  42 Downloads (Pure)

• An 85-year old patient with severe ongoing bleeding

  Jongbloed, F., de Leur, K., Heetman, C., de Maat, M. & Wils, E. J., Nov 2022, In: Netherlands Journal of Critical Care. 30, 6, p. 194-198 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Bleeding 100%
  • Dabigatran 100%
  • Kidney Failure 33%
  • Idarucizumab 33%
  • Drug-Drug Interaction 16%
  1 Citation (Scopus)

• Zuurstoftoediening met hoge nasale flow bij covid-19

  Translated title of the contribution: High flow nasal oxygen in patients with COVID-19Elshof, J., Wils, E. J., Heunks, L. M. A., Dieperink, P. & Duiverman, M. L., 26 Sept 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166

  Research output: Contribution to journal › Article › Academic › peer-review

  • Clinical Practice 100%
  • Intubation 100%
  • Pandemic 100%
  • Respiratory Failure 100%
  • Oxygen Therapy 100%

• Effect of intensive care unit-specific virtual reality (ICU-VR) to improve psychological well-being in ICU survivors: study protocol for an international, multicentre, randomised controlled trial-the HORIZON-IC study

  Vlake, J. H., van Bommel, J., Wils, E. J., Korevaar, T. I., Taccone, F., Schut, A. F., Elderman, J. H., Labout, J. A., Raben, A. M., Dijkstra, A., Achterberg, S., Jurriens, A. L., Van Mol, M. M., Gommers, D. & Van Genderen, M. E., 20 Sept 2022, In: BMJ Open. 12, 9, e061876.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Psychological Well-Being 100%
  • Randomized Controlled Trial 100%
  • Intensive Care Unit 100%
  • Posttraumatic Stress Disorder 8%
  • Quality of Life 8%
  4 Citations (Scopus)

  74 Downloads (Pure)

• Airborne SARS-CoV-2 RNA excretion by patients with COVID-19 on different oxygen-delivery systems: a prospective observational study

  Janssen, M. L., Klazen, Y. P., de Man, P., Hanselaar, W., Ong, D. S. Y. & Wils, E. J., May 2022, In: Journal of Hospital Infection. 123, p. 87-91 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Observational Study 100%
  • Air Sampling 100%
  • COVID-19 100%
  • Nasal Cannula 100%
  4 Citations (Scopus)

• Dynamic prediction of mortality in COVID-19 patients in the intensive care unit: A retrospective multi-center cohort study

  Smit, J. M., Krijthe, J. H., Endeman, H., Tintu, A. N., de Rijke, Y. B., Gommers, D. A. M. P. J., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E. J., Frenzel, T., Dongelmans, D. A., De Jong, R., Peters, M. A. A., Kamps, M. J. A., Ramnarain, D., Nowitzky, R., Nooteboom, F. G. C. A., De Ruijter, W. & Urlings-Strop, L. C. & 27 others, Smit, E. G. M., Mehagnoul-Schipper, D. J., Dormans, T., De Jager, C. P. C., Hendriks, S. H. A., Achterberg, S., Oostdijk, E., Reidinga, A. C., Festen-Spanjer, B., Brunnekreef, G. B., Cornet, A. D., Van den Tempel, W., Boelens, A. D., Koetsier, P., Lens, J. A., Faber, H. J., karakus, A., Entjes, R., De Jong, P., Rettig, T. C. D., Arbous, M. S., Lalisang, R. C. A., Tonutti, M., De Bruin, D. P., Elbers, P. W. G., Van Bommel, J. & Reinders, M. J. T., Jan 2022, In: Intelligence-Based Medicine. 6, 100071.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Random Decision Forest 100%
  • Logistic Regression 100%
  • Cohort Study 100%
  • Nonoxynol-9 100%
  • Resource Allocation 100%
  5 Citations (Scopus)

  45 Downloads (Pure)
• 2021

  Virtual Reality to Improve Sequelae of the Postintensive Care Syndrome: A Multicenter, Randomized Controlled Feasibility Study

  Vlake, J. H., Van Bommel, J., Wils, E.-J., Korevaar, T. I. M., Bienvenu, O. J., Klijn, E., Gommers, D. & van Genderen, M. E., Sept 2021, In: Critical Care Explorations. 3, 9, e0538.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Sequela 100%
  • Quality of Life 100%
  • Mental Health 75%
  • Posttraumatic Stress Disorder 50%
  • Critical Illness 50%
  24 Citations (Scopus)

  55 Downloads (Pure)

• Anti-infectious decontamination strategies in Dutch intensive care units: A survey study on contemporary practice and heterogeneity

  Elderman, J. H., Ong, D. S. Y., van der Voort, P. H. J. & Wils, E. J., Aug 2021, In: Journal of Critical Care. 64, p. 262-269 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Intensive Care Unit 100%
  • Decontamination 100%
  • Clinical Outcome 14%
  • Practice Guideline 14%
  8 Citations (Scopus)

• Psychologic Distress and Quality of Life After ICU Treatment for Coronavirus Disease 2019: A Multicenter, Observational Cohort Study

  Vlake, J. H., Van Bommel, J., Hellemons, M. E., Wils, E.-J., Bienvenu, O. J., Schut, A. F. C., Klijn, E., Van Bavel, M. P., Gommers, D. & Van Genderen, M. E., Aug 2021, In: Critical Care Explorations. 3, 8, e0497.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • COVID-19 100%
  • Quality of Life 100%
  • Cohort Study 100%
  • Mental Health 60%
  • Hospital Anxiety and Depression Scale 30%
  19 Citations (Scopus)

  83 Downloads (Pure)

• Virtual Reality Tailored to the Needs of Post-ICU Patients: A Safety and Immersiveness Study in Healthy Volunteers

  Vlake, J. H., Wils, E.-J., van Bommel, J., Korevaar, T. I. M., Gommers, D. & van Genderen, M. E., May 2021, In: Critical Care Explorations. 3, 5, p. e0388

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Virtual Reality 100%
  • Healthy Volunteer 100%
  • Volunteer 100%
  • Main Result 100%
  • Quality of Life 100%
  12 Citations (Scopus)

  71 Downloads (Pure)
• 2012

  Keratinocyte Growth Factor and Stem Cell Factor to Improve Thymopoiesis after Autologous CD34(+) Cell Transplantation in Rhesus Macaques

  Wils, E.-J., Kaya, F., Rombouts, E., Mourik, I., Rijken-Schelen, A., Visser, T., Braakman, E., Wagemaker, G. & Cornelissen, J., 2012, In: Biology of Blood and Marrow Transplantation. 18, 1, p. 55-65 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)
• 2011

  Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients

  Wils, E.-J., van der Holt, R., Broers, Sluijs, S., Gratama, J. W., Braakman, E. & Cornelissen, J., 2011, In: Haematologica. 96, 12, p. 1846-1854 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  49 Citations (Scopus)

• Stem Cell Factor Consistently Improves Thymopoiesis after Experimental Transplantation of Murine or Human Hematopoietic Stem Cells in Immunodeficient Mice

  Wils, E.-J., Rombouts, E., Mourik, I., Spits, H., Legrand, N., Braakman, E. & Cornelissen, J., 2011, In: Journal of Immunology. 187, 6, p. 2974-2981 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  12 Citations (Scopus)
• 2007

  Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation

  Wils, E.-J., Braakman, E., Verjans, G., Rombouts, E., Broers, A., Niesters, H., Wagemaker, G., Staal, F., Löwenberg, B., Spits, H. & Cornelissen, J., 2007, In: Journal of Immunology. 178, 6, p. 3551-3557 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  40 Citations (Scopus)

• IL-7 mediated protection against minor antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells

  Broers, A., Bruinsma, M., Sluijs, S., Wils, E.-J., Spits, H., Löwenberg, B., Braakman, E. & Cornelissen, J., 2007, In: Haematologica. 92, 8, p. 1099-1106 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1 Citation (Scopus)
• 2005

  Thymopoiesis following allogeneic stem cell transplantation: new possibilities for improvement

  Wils, E.-J. & Cornelissen, J., 2005, In: Blood Reviews. 19, 2, p. 89-98 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  38 Citations (Scopus)