prof. dr. HLA Janssen

Search results

• 2013

  Relapse of Chronic Hepatitis B After Discontinuation of Nucleos(t)ide Analogs: Is the Glass Half Full or Half Empty?

  Reijnders, J. & Janssen, HLA., 2013, In: Hepatology. 58, 6, p. 1885-1887 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)

• Reply to: "Identification of chronic hepatitis B"

  Veldhuijzen, I. & Janssen, HLA., 2013, In: Journal of Hepatology. 58, 5, p. 1058-1058 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Response-Guided Peginterferon Therapy in Hepatitis B e Antigen-Positive Chronic Hepatitis B Using Serum Hepatitis B Surface Antigen Levels

  Sonneveld, M., Hansen, B., Piratvisuth, T., Jia, JD., Zeuzem, S., Gane, E., Liaw, YF., Xie, Q., Heathcote, EJ., Chan, HLY. & Janssen, HLA., 2013, In: Hepatology. 58, 3, p. 872-880 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  180 Citations (Scopus)

• Response guided treatment for peginterferon in chronic hepatitis b

  Arends, P. & Janssen, HLA., 2013, In: Current Hepatitis Reports. 12, 2, p. 88-95 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Role of anticoagulant therapy in liver disease

  Plompen, L., Schouten, J. & Janssen, HLA., 2013, In: Hepatology International. 7, 2, p. 369-376 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Role of T cell immunity in hepatitis C virus infections

  Claassen, M., Janssen, HLA. & Boonstra, A., 2013, In: Current Opinion in Virology. 3, 4, p. 461-467 7 p.

  Research output: Contribution to journal › Article › Academic
  28 Citations (Scopus)

• Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122

  van der Meer, A., Farid, W., Sonneveld, M., Ruiter, P., Boonstra, A., van Vuuren, H., Verheij, J., Hansen, B., de Knegt, R., van der Laan, L. & Janssen, HLA., 2013, In: Journal of Viral Hepatitis. 20, 3, p. 158-166 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  71 Citations (Scopus)

• Serum levels of interferon-gamma-inducible protein 10 and response to peginterferon therapy in HBeAg-positive chronic hepatitis B

  Sonneveld, M., Arends, P., Boonstra, A., Hansen, B. & Janssen, HLA., 2013, In: Journal of Hepatology. 58, 5, p. 898-903 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  46 Citations (Scopus)

• Studies of IL28B genotype and response to peginterferon in chronic hepatitis B should be stratified by HBV genotype

  Sonneveld, M., Brouwer, W. P. & Janssen, HLA., 2013, In: Hepatology. 57, 3, p. 1283-1283 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C Reply

  van der Meer, A., Hansen, B. & Janssen, HLA., 2013, In: JAMA - Journal of the American Medical Association. 309, 14, p. 1457-1457 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Scopus)

• Sustained virologic response after therapy with the HCV protease inhibitor narlaprevir in combination with peginterferon and ribavirin is durable through long-term follow-up

  Hotho, D., Bruijne, J., Spaan, M., Treitel, MA., Boonstra, A., de Knegt, R., Janssen, HLA. & Reesink, HW., 2013, In: Journal of Viral Hepatitis. 20, 4, p. e78-e81

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Treatment of HCV Infection by Targeting MicroRNA

  Janssen, HLA., Reesink, HW., Lawitz, EJ., Zeuzem, S., Rodriguez-Torres, M., Patel, KN., van der Meer, A., Patick, AK., Chen, A., Zhou, Y., Persson, R., King, BD., Kauppinen, S., Levin, AA. & Hodges, MR., 2013, In: New England Journal of Medicine. 368, 18, p. 1685-1694 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1751 Citations (Scopus)

• Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma

  Hernanda, PY., Pedroza Gonzalez, A., van der Laan, L., Broker, MEE., Hoogduijn, M., IJzermans, J. N. M., Bruno, M., Janssen, HLA., Peppelenbosch, M. & Pan, Q., 2013, In: Carcinogenesis. 34, 10, p. 2330-2340 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)

• Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis

  Zoutendijk, R., Reijnders, J., Zoulim, F., Brown, A., Mutimer, DJ., Deterding, K., Hofmann, WP., Petersen, J., Fasano, M., Buti, M., Berg, T., Hansen, B., Sonneveld, M., Wedemeyer, H. & Janssen, HLA., 2013, In: Gut. 62, 5, p. 760-765 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  141 Citations (Scopus)
• 2012

  A dynamic perspective of RNAi library development

  Pan, Q., van der Laan, L., Janssen, HLA. & Peppelenbosch, M., 2012, In: Trends in Biotechnology. 30, 4, p. 206-215 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Alveolar epithelial cells orchestrate DC function in murine viral pneumonia

  Unkel, B., Hoegner, K., Clausen, B., Lewe-Schlosser, P., Bodner, J., Gattenloehner, S., Janssen, HLA., Seeger, W., Lohmeyer, J. & Herold, S., 2012, In: Journal of Clinical Investigation. 122, 10, p. 3652-3664 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  81 Citations (Scopus)

• Antiviral or proviral action of mycophenolic acid in hepatitis B infection?

  Pan, Q., van Vuuren, H., van der Laan, L., Peppelenbosch, M. & Janssen, HLA., 2012, In: Hepatology. 56, 4, p. 1586-1587 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Association Between Sustained Virological Response and All-Cause Mortality Among Patients With Chronic Hepatitis C and Advanced Hepatic Fibrosis

  van der Meer, A., Veldt, B., Feld, JJ., Wedemeyer, H., Dufour, JF., Lammert, F., Duarte-Rojo, A., Heathcote, EJ., Manns, MP., Kuske, L., Zeuzem, S., Hofmann, WP., de Knegt, R., Hansen, B. & Janssen, HLA., 2012, In: JAMA - Journal of the American Medical Association. 308, 24, p. 2584-2593 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1226 Citations (Scopus)

• Continuous interferon-alpha 2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients

  Roomer, R., Bergmann, J., Boonstra, A., Hansen, B., Haagmans, B., Kwadijk, S., van Vuuren, H., de Knegt, R. & Janssen, HLA., 2012, In: Antiviral Therapy. 17, 3, p. 509-517 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)

• Durable hepatitis B surface antigen decline in hepatitis B e antigen-positive chronic hepatitis B patients treated with pegylated interferon-alpha 2b: relation to response and HBV genotype

  Sonneveld, M., Rijckborst, V., Cakaloglu, Y., Simon, K., Heathcote, EJ., Tabak, F., Mach, T., Boucher, C., Hansen, B., Zeuzem, S. & Janssen, HLA., 2012, In: Antiviral Therapy. 17, 1, p. 9-17 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  55 Citations (Scopus)

• EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

  Papatheodoridis, G., Buti, M., Cornberg, M., Janssen, HLA., Mutimer, D., van de Pol, S. & Raimondo, G., 2012, In: Journal of Hepatology. 57, 1, p. 167-185 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  2719 Citations (Scopus)

• Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study

  Petersen, J., Ratziu, V., Buti, M., Janssen, HLA., Brown, A., Lampertico, P., Schollmeyer, J., Zoulim, F., Wedemeyer, H., Sterneck, M., Berg, T., Sarrazin, C., Lutgehetmann, M. & Buggisch, P., 2012, In: Journal of Hepatology. 56, 3, p. 520-526 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  113 Citations (Scopus)

• Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees

  Verstrepen, B., de Groot, NG., Groothuismink, A., Verschoor, EJ., Groen, R., Bogers, WM., Janssen, HLA., Mooij, P., Bontrop, RE., Koopman, G. & Boonstra, A., 2012, In: PLoS One (print). 7, 10

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hepatitis 100%
  • Hepatitis C Virus 74%
  • Humans 62%
  • Hepatitis C 62%
  • Single Nucleotide Polymorphism 50%
  4 Citations (Scopus)

  5 Downloads (Pure)

• Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C

  Verveer, C., Zondervan, P., Kate, F., Hansen, B., Janssen, HLA. & de Knegt, R., 2012, In: Liver International. 32, 4, p. 622-628 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  65 Citations (Scopus)

• Evidence for an enhanced fibrinolytic capacity in cirrhosis as measured with two different global fibrinolysis tests

  Rijken, D., Kock, EL., Guimaraes, AHC., Talens, S., Darwish Murad, S. & Janssen, HLA., 2012, In: Journal of Thrombosis and Haemostasis. 10, 10, p. 2116-2122 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  71 Citations (Scopus)

• Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

  Pan, Q., Ramakrishnaiah, V., Henry, SD., Fouraschen, S., Ruiter, P., Kwekkeboom, J., Tilanus, H., Janssen, HLA. & van der Laan, L., 2012, In: Gut. 61, 9, p. 1330-1339 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  67 Citations (Scopus)

• Hepatitis B Surface Antigen Declines and Clearance During Long-Term Tenofovir Therapy in Patients Coinfected With HBV and HIV

  Zoutendijk, R., Zaaijer, HL., De Vries - Sluijs, T. E. M. S., Reijnders, J., Mulder, JW., Kroon, FP., Richter, C., Baltissen - van der Eijk, A., Sonneveld, M., Hansen, B., de Man, R., Ende, M. & Janssen, HLA., 2012, In: Journal of Infectious Diseases. 206, 6, p. 974-980 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  60 Citations (Scopus)

• Hepatitis B virus suppresses the functional interaction between natural killer cells and plasmacytoid dendritic cells

  Shi, S., Tjwa, E., Biesta, P., Boonstra, A., Xie, Q., Janssen, HLA. & Woltman, A., 2012, In: Journal of Viral Hepatitis. 19, 2, p. E26-E33

  Research output: Contribution to journal › Article › Academic › peer-review
  27 Citations (Scopus)

• Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation

  Farid, W., Pan, Q., van der Meer, A., Ruiter, P., Ramakrishnaiah, V., de Jonge, J., Kwekkeboom, J., Janssen, HLA., Metselaar, H., Tilanus, H., Kazemier, G. & van der Laan, L., 2012, In: Liver Transplantation. 18, 3, p. 290-297 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  154 Citations (Scopus)

• Identification and treatment of chronic hepatitis B in Chinese migrants: Results of a project offering on-site testing in Rotterdam, The Netherlands

  Veldhuijzen, I., Wolter, R., Rijckborst, V., Mostert, M., Voeten, H., Cheung, Y., Boucher, C., Reijnders, J., Zwart, O. & Janssen, HLA., 2012, In: Journal of Hepatology. 57, 6, p. 1171-1176 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  34 Citations (Scopus)

• Idiopathic noncirrhotic portal hypertension is associated with poor survival: results of a long-term cohort study

  Schouten, J., Nevens, F., Hansen, B., Laleman, W., van den Born, M., Komuta, M., Roskams, T., Verheij, J. & Janssen, HLA., 2012, In: Alimentary Pharmacology & Therapeutics. 35, 12, p. 1424-1433 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  45 Citations (Scopus)

• IL28B polymorphism and hepatitis C: A genetic marker of peginterferon-alpha sensitivity devoid from classical interferon-alpha side effects?

  Orlent, HHGHA., de Knegt, R. & Janssen, HLA., 2012, In: Journal of Hepatology. 56, 3, p. 741-742 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Immunology of hepatitis C virus infections

  Spaan, M., Janssen, HLA. & Boonstra, A., 2012, In: Best Practice & Research in Clinical Gastroenterology. 26, 4, p. 391-400 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages

  Movita, D., Kreefft, K., Biesta, P., Oudenaren, A., Leenen, P., Janssen, HLA. & Boonstra, A., 2012, In: Journal of Leukocyte Biology. 92, 4, p. 723-733 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  71 Citations (Scopus)

• Letter: non-cirrhotic portal hypertension and end-stage liver disease - authors' reply

  Schouten, J. & Janssen, HLA., 2012, In: Alimentary Pharmacology & Therapeutics. 36, 7, p. 687-688 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Long-term follow-up of hepatitis B e antigen-negative patients treated with peginterferon alpha-2a: progressive decrease in hepatitis B surface antigen in responders

  Rijckborst, V., Ferenci, P., Akdogan, M., Pinarbasi, B., Borg, M., Simon, K., Flisiak, R., Akarca, US., Raptopoulou-Gigi, M., Verheij-Hart, E., van Vuuren, H., Boucher, C., Hansen, B. & Janssen, HLA., 2012, In: European Journal of Gastroenterology & Hepatology. 24, 9, p. 1012-1019 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C Virus infection in vitro and in vivo

  Pan, Q., Ruiter, P., Metselaar, H., Kwekkeboom, J., de Jonge, J., Tilanus, H., Janssen, HLA. & van der Laan, L., 2012, In: Hepatology. 55, 6, p. 1673-1683 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis

  Smalberg, J., Arends, L., Valla, DC., Kiladjian, JJ., Janssen, HLA. & Leebeek, F., 2012, In: Blood. 120, 25, p. 4921-4928 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  251 Citations (Scopus)

• Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy

  Claassen, M., de Knegt, R., Turgut, D., Groothuismink, A., Janssen, HLA. & Boonstra, A., 2012, In: PLoS One (print). 7, 11

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  11 Citations (Scopus)

  10 Downloads (Pure)

• Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design

  Hotho, D., Bruijne, J., O'Farrell, AM., Boyea, T., Li, JK., Bracken, M., Li, X., Campbell, D., Guler, HP., Weegink, CJ., Schinkel, J., Molenkamp, R., de Rooij, JJV., van Vliet, AHM., Janssen, HLA., de Knegt, R. & Reesink, HW., 2012, In: Antiviral Therapy. 17, 2, p. 365-375 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Normal Human 100%
  • Placebo 75%
  • Proteinase Inhibitor 50%
  • Pharmacokinetics 50%
  • Antiviral Activity 50%
  7 Citations (Scopus)

• PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function

  Laar, L., Bosch, A., Boonstra, A., Binda, RS., Buitenhuis, M., Janssen, HLA., Coffer, PJ. & Woltman, A., 2012, In: Blood. 120, 25, p. 4982-4991 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  26 Citations (Scopus)

• Polymorphisms Near IL28B and Serologic Response to Peginterferon in HBeAg-Positive Patients With Chronic Hepatitis B

  Sonneveld, M., Wong, VWS., Woltman, A., Wong, GLH., Cakaloglu, Y., Zeuzem, S., Buster, E., Uitterlinden, A., Hansen, B., Chan, HLY. & Janssen, HLA., 2012, In: Gastroenterology. 142, 3, p. 513-U165

  Research output: Contribution to journal › Article › Academic › peer-review
  152 Citations (Scopus)

• Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7

  Boonstra, A., Liu, B., Groothuismink, A., Bergmann, J., Bruijne, J., Hotho, D., Hansen, B., van Vliet, AA., de Rooij, JJV., Fletcher, SP., Bauman, LA., Rahimy, M., Appleman, JR., Freddo, JL., Reesink, HW., de Knegt, R. & Janssen, HLA., 2012, In: Antiviral Therapy. 17, 4, p. 657-667 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hepatitis C 100%
  • TLR 7 100%
  • Chronic Hepatitis C 100%
  • Toll Like Receptor 7 100%
  • Agonist 60%
  24 Citations (Scopus)

• Pregnancy in women with portal vein thrombosis: Results of a multicentric European study on maternal and fetal management and outcome

  Hoekstra, J., Seijo, S., Rautou, PE., Ducarme, G., Boudaoud, L., Luton, D., Alijotas-Reig, J., Casellas-Caro, M., Condat, B., Bresser, E., Thabut, D., Larroque, B., Garcia-Pagan, JC., Janssen, HLA., Valla, DC. & Plessier, A., 2012, In: Journal of Hepatology. 57, 6, p. 1214-1219 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)

• Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B

  Sonneveld, M., Rijckborst, V., Zeuzem, S., Heathcote, EJ., Simon, K., Senturk, H., Pas, S., Hansen, B. & Janssen, HLA., 2012, In: Hepatology. 56, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)

• Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study

  Koehler, E., Schouten, J., Hansen, B., van Rooij, FJA., Hofman, B., Stricker, B. & Janssen, HLA., 2012, In: Journal of Hepatology. 57, 6, p. 1305-1311 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  178 Citations (Scopus)

• Prothrombotic disorders in abdominal vein thrombosis

  Leebeek, F., Smalberg, J. & Janssen, HLA., 2012, In: Netherlands Journal of Medicine. 70, 9, p. 400-405 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  26 Citations (Scopus)

• Psychiatric Side Effects and Fluctuations in Serotonergic Parameters in the Treatment of Chronic Hepatitis C Infection

  Bezemer, G., Gool, AR., Fekkes, D., Vrolijk, JM., Hansen, B., Janssen, HLA. & de Knegt, R., 2012, In: Neuropsychobiology. 65, 3, p. 126-132 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• Quantification of serum hepatitis B surface antigen: is it useful for the management of chronic hepatitis B?

  Janssen, HLA., Sonneveld, M. & Brunetto, MR., 2012, In: Gut. 61, 5, p. 641-645 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  16 Citations (Scopus)

• Randomised clinical trial: escitalopram for the prevention of psychiatric adverse events during treatment with peginterferon-alfa-2a and ribavirin for chronic hepatitis C (vol 34, pg 1306, 2011)

  de Knegt, R., Bezemer, G., Gool, AR., Drenth, JPH., Hansen, B., Droogleever Fortuijn, CE., Weegink, CJ., Hengeveld, M. & Janssen, HLA., 2012, In: Alimentary Pharmacology & Therapeutics. 35, 7, p. 864-864 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review