Isabel Retel Helmrich

2024

A decade of public engagement regarding human germline gene editing: a systematic scoping review

Geuverink, W. P., Houtman, D., Retel Helmrich, I. R. A., DNA Dialogues Consortium, Kist, J. D., Henneman, L., Cornel, M. C. & Riedijk, S. R., 28 Nov 2024, (E-pub ahead of print) In: European Journal of Human Genetics. 10 p.

Research output: Contribution to journal › Review article › Academic › peer-review

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Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study

Pisica, D., Volovici, V., Yue, J. K., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Van Essen, T. A., Den Boogert, H. F., Vande Vyvere, T., Haitsma, I., Nieboer, D., Markowitz, A. J., Yuh, E. L., Steyerberg, E. W., Peul, W. C., Dirven, C. M. F., Menon, D. K., Manley, G. T., Maas, A. I. R. & Lingsma, H., 1 Nov 2024, In: Neurosurgery. 95, 5, p. 986-999 14 p.

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1 Citation (Scopus)

Imaging Findings in Acute Traumatic Brain Injury: a National Institute of Neurological Disorders and Stroke Common Data Element-Based Pictorial Review and Analysis of Over 4000 Admission Brain Computed Tomography Scans from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

Vande Vyvere, T., Pisica, D., Wilms, G., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Claes, L., Van Dyck, P., Snoeckx, A., van Den Hauwe, L., Pullens, P., Verheyden, J., Wintermark, M., Dekeyzer, S., Mac Donald, C. L., Maas, A. I. R., Parizel, P. M., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L. & Anke, A. & 30 others, Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., Beauvais, R., Foks, K., Gravesteijn, B., Haagsma, J. A., Haitsma, I., Huijben, J., Kompanje, E., Lingsma, H., Mikolic, A., Nieboer, D., Polinder, S., Helmrich, I. R., Sewalt, C., Singh, R. D., Steyerberg, E. W., Tibboel, D., Timmers, M., van der Jagt, M., van Essen, T. A., van Veen, E., Velt, K., Volovici, V., Voormolen, D. & Wiegers, E., 21 Oct 2024, In: Journal of Neurotrauma. 41, 19-20, p. 2248-2297 50 p.

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4 Citations (Scopus)

32 Downloads (Pure)

The need to set explicit goals for human germline gene editing public dialogues

Geuverink, W. P., Houtman, D. & the ‘De DNA dialogen’ consortium, Jun 2024, In: Journal of Community Genetics. 15, 3, p. 259-265 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

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3 Citations (Scopus)

11 Downloads (Pure)

Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI

Howe, E. I., Andelic, N., Brunborg, C., Zeldovich, M., Helseth, E., Skandsen, T., Olsen, A., Fure, S. C. R., Theadom, A., Rauen, K., Madsen, B. Å., Jacobs, B., van der Naalt, J., Tartaglia, M. C., Einarsen, C. E., Storvig, G., Tronvik, E., Tverdal, C., von Steinbüchel, N. & Røe, C. & 241 others, Hellstrøm, T., Åkerlund, C., Amrein, K., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., Beauvais, R., Beer, R., Bellander, B.-M., Belli, A., Benali, H., Berardino, M., Beretta, L., Blaabjerg, M., Bragge, P., Brazinova, A., Brinck, V., Brooker, J., Brorsson, C., Buki, A., Bullinger, M., Cabeleira, M., Caccioppola, A., Calappi, E., Calv, M. R., Cameron, P., Lozano, G. C., Carbonara, M., Cavallo, S., Chevallard, G., Chieregato, A., Citerio, G., Clusmann, H., Coburn, M., Coles, J., Cooper, J. D., Correia, M., Čović, A., Curry, N., Czeiter, E., Czosnyka, M., Dahyot-Fizelier, C., Dark, P., Dawes, H., DeKeyser, V., Degos, V., Corte, F. D., Boogert, H. D., Depreitere, B., Đilvesi, Đ., Dixit, A., Donoghue, E., Dreier, J., Dulière, G.-L., Ercole, A., Esser, P., Ezer, E., Fabricius, M., Feigin, V. L., Foks, K., Frisvold, S., Furmanov, A., Gagliardo, P., Galanaud, D., Gantner, D., Gao, G., George, P., Ghuysen, A., Giga, L., Glocker, B., Golubovic, J., Gomez, P., Gravesteijn, J. G. B., Grossi, F., Gruen, R., Gupta, D., Haagsma, J., Haitsma, I., Helbok, R., Horton, L., Huijben, J., Hutchinson, P., Jankowski, S., Jarrett, M., Jiang, J.-Y., Johnson, F., Jones, K., Karan, M., Kolias, A., Kompanje, E., Kondziella, D., Kornaropoulos, E., Koskinen, L.-O., Kovács, N., Kowark, A., Lagares, A., Lanyon, L., Laureys, S., Lecky, F., Ledoux, D., Lefering, R., Legrand, V., Lejeune, A., Levi, L., Lightfoot, R., Lingsma, H., Maas, A. R., Castaño-León, A. M., Maegele, M., Majdan, M., Manara, A., Manley, G., Martino, C., Maréchal, H., Mattern, J., McMahon, C., Melegh, B., Menon, D., Menovsky, T., Mikolic, A., Misset, B., Muraleedharan, V., Murray, L., Negru, A., Nelson, D., Newcombe, V., Nieboer, D., Nyirádi, J., Olubukola, O., Oresic, M., Ortolano, F., Palotie, A., Parizel, P. M., Payen, J.-F., Perera, N., Perlbarg, V., Persona, P., Peul, W., Piippo-Karjalainen, A., Pirinen, M., Pisica, D., Ples, H., Polinder, S., Pomposo, I., Posti, J. P., Puybasset, L., Radoi, A., Ragauskas, A., Raj, R., Rambadagalla, M., Helmrich, I. R., Rhodes, J., Richardson, S., Richter, S., Ripatti, S., Rocka, S., Roise, O., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossaint, R., Rossi, S., Rusnák, D. R. M., Sahuquillo, J., Sakowitz, O., Sanchez-Porras, R., Sandor, J., Schäfer, N., Schmidt, S., Schoechl, H., Schoonman, G., Schou, R. F., Schwendenwein, E., Sewalt, C., Singh, R. D., Smielewski, P., Sorinola, A., Stamatakis, E., Stanworth, S., Stevens, R., Stewart, W., Steyerberg, E. W., Stocchetti, N., Sundström, N., Takala, R., Tamás, V., Tamosuitis, T., Taylor, M., Thibaut, A., Ao, B. T., Tenovuo, O., Thomas, M., Tibboel, D., Timmers, M., Tolias, C., Trapani, T., Tudora, C., Unterberg, A., Vajkoczy, P., Vallance, S., Valeinis, E., Vámos, Z., van der Jagt, M., Van der Steen, G., van Dijck, J. T. J. M., van Erp, I. A. M., van Essen, T. A., VanHecke, W., van Heugten, C., van Veen, E., Vyvere, T. V., van Wijk, R. P. J., Vargiolu, A., Vega, E., Velt, K., Verheyden, J., Vespa, P. M., Vik, A., Vilcinis, R., Volovici, V., Voormolen, D., Vulekovic, P., Wang, K. W., Whitehouse, D., Wiegers, E., Williams, G., Wilson, L., Winzeck, S., Wolf, S., Yang, Z., Ylén, P., Zeiler, F. A., Zelinkova, V., Ziverte, A. & TommasoZoerle, 25 Mar 2024, In: The journal of headache and pain. 25, 1, 44.

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Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study

Åkerlund, C., Holst, A., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Bhattacharyay, S., Stocchetti, N., Steyerberg, E., Smielewski, P., Menon, D. K., Ercole, A. & Nelson, D. W., Jan 2024, In: The Lancet Neurology. 23, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

2023

Prognostic research: Methodological aspects and applications in acute care

Retel Helmrich, I., 4 Oct 2023, Rotterdam. 291 p.

Research output: Types of Thesis › Doctoral Thesis › Internal

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Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study

van Essen, T. A., van Erp, I. A. M., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Lingsma, H. F., Pisică, D., Yue, J. K., Singh, R. D., van Dijck, J. T. J. M., Volovici, V., Younsi, A., Kolias, A., Peppel, L. D., Heijenbrok-Kal, M., Ribbers, G. M., Menon, D. K., Hutchinson, P. J. A., Manley, G. T., Depreitere, B., Steyerberg, E. W. & Maas, A. I. R. & 2 others, de Ruiter, G. C. W. & Peul, W. C., Sept 2023, In: EClinicalMedicine. 63, 102161.

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23 Citations (Scopus)

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“What if” should precede “whether” and “how” in the social conversation around human germline gene editing

Houtman, D., Geuverink, W., Helmrich, I. R. A. R., Vijlbrief, B., Cornel, M. & Riedijk, S., Aug 2023, In: Journal of Community Genetics. 14, 4, p. 371-375 5 p.

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5 Citations (Scopus)

32 Downloads (Pure)

Mortality Prediction in Severe Traumatic Brain Injury Using Traditional and Machine Learning Algorithms

Wu, X., Sun, Y., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Xu, X., Steyerberg, E. W., Helmrich, I. R. A. R., Lecky, F., Guo, J., Li, X., Feng, J., Mao, Q., Xie, G., Maas, A. I. R., Gao, G. & Jiang, J., 1 Jul 2023, In: Journal of Neurotrauma. 40, 13-14, p. 1366-1375 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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16 Citations (Scopus)

251 Downloads (Pure)

US and Dutch Perspectives on the Use of COVID-19 Clinical Prediction Models: Findings from a Qualitative Analysis

Basile, M. J., Helmrich, I. R. A. R., Park, J. G., Polo, J., Rietjens, J. A. C., van Klaveren, D., Zanos, T. P., Nelson, J., Lingsma, H. F., Kent, D. M., Alsma, J., Verdonschot, R. J. C. G. & Hajizadeh, N., May 2023, In: Medical Decision Making. 43, 4, p. 445-460 16 p., 272989X231152852.

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

2022

Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study

Howe, E. I., Zeldovich, M., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Andelic, N., von Steinbuechel, N., Fure, S. C. R., Borgen, I. M. H., Forslund, M. V., Hellstrøm, T., Søberg, H. L., Sveen, U., Rasmussen, M., Kleffelgaard, I., Tverdal, C., Helseth, E., Løvstad, M., Lu, J., Arango-Lasprilla, J. C., Tenovuo, O. & Azouvi, P. & 31 others, Dawes, H., Roe, C., Åkerlund, C., Amrein, K., Andreassen, L., Anke, A., Antoni, A., Foks, K., Gravesteijn, B., Haagsma, J. A., Haitsma, I., Huijben, J., Kompanje, E., Lingsma, H., Mikolic, A., Nieboer, D., Pisica, D., Polinder, S., Helmrich, I. R., Sewalt, C., Singh, R. D., Steyerberg, E. W., Tibboel, D., Timmers, M., van der Jagt, M., van Essen, T. A., van Veen, E., Velt, K., Volovici, V., Voormolen, D. & Wiegers, E., 16 Dec 2022, In: Bmc Health Services Research. 22, 1, 1536.

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9 Citations (Scopus)

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Prognostic models for COVID-19 needed updating to warrant transportability over time and space

van Klaveren, D., Zanos, T. P., Nelson, J., Levy, T. J., Park, J. G., Retel Helmrich, I. R. A., Rietjens, J. A. C., Basile, M. J., Hajizadeh, N., Lingsma, H. F. & Kent, D. M., 23 Nov 2022, In: BMC Medicine. 20, 1, 456.

Research output: Contribution to journal › Article › Academic › peer-review

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1 Citation (Scopus)

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Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury

Wilson, L., Horton, L., Polinder, S., Newcombe, V. F. J., Steinbuechel, N. V., Maas, A. I. R., Menon, D. K. & Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, 1 Oct 2022, In: Journal of Neurotrauma. 39, 19-20, p. 1363-1381 19 p.

Research output: Contribution to journal › Article › Academic › peer-review

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13 Citations (Scopus)

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

Helmrich, I. R. A. R., Czeiter, E., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Amrein, K., Büki, A., Lingsma, H. F., Menon, D. K., Mondello, S., Steyerberg, E. W., von Steinbüchel, N., Wang, K. K. W., Wilson, L., Xu, H., Yang, Z., van Klaveren, D. & Maas, A. I. R., 1 Sept 2022, In: The Lancet Neurology. 21, 9, p. 792-802 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study

van der Vlegel, M., Mikolić, A., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Lee Hee, Q., Kaplan, Z. L. R., Retel Helmrich, I. R. A., van Veen, E., Andelic, N., Steinbuechel, N. V., Plass, A. M., Zeldovich, M., Wilson, L., Maas, A. I. R., Haagsma, J. A. & Polinder, S., 1 Aug 2022, In: Injury. 53, 8, p. 2774-2782 9 p.

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21 Citations (Scopus)

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Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study

Åkerlund, C., Holst, A., Stocchetti, N., Steyerberg, E. W., Menon, D. K., Ercole, A., Nelson, D. W. & Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, 27 Jul 2022, In: Critical Care. 26, 1, 228.

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48 Citations (Scopus)

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Discrepancy between disability and reported well-being after traumatic brain injury

Retel Helmrich, I. R. A., Van Klaveren, D., Andelic, N., Lingsma, H., Maas, A., Menon, D., Polinder, S., Røe, C., Steyerberg, E. W., Van Veen, E. & Wilson, L., 13 Jul 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, 7, p. 785-796 12 p.

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14 Citations (Scopus)

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Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?

Ceyisakar, I. E., Huijben, J., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Maas, A. I. R., Lingsma, H. F. & van Leeuwen, N., Jun 2022, In: Neurocritical Care. 36, 3, p. 846-856 11 p.

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4 Citations (Scopus)

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Serum metabolome associated with severity of acute traumatic brain injury

Thomas, I., Dickens, A. M., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants, Posti, J. P., Czeiter, E., Duberg, D., Sinioja, T., Kråkström, M., Retel Helmrich, I. R. A., Wang, K. K. W., Maas, A. I. R., Steyerberg, E. W., Menon, D. K., Tenovuo, O., Hyötyläinen, T., Büki, A. & Orešič, M., 10 May 2022, In: Nature Communications. 13, 1, 2545.

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49 Citations (Scopus)

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Does poor methodological quality of prediction modeling studies translate to poor model performance? An illustration in traumatic brain injury

Helmrich, I. R. A. R., Mikolić, A., Kent, D. M., Lingsma, H. F., Wynants, L., Steyerberg, E. W. & van Klaveren, D., 5 May 2022, In: Diagnostic and Prognostic Research. 6, 1, 8.

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Update on a Model to Minimize Population Health Loss in Times of Scarce Surgical Capacity During the COVID-19 Crisis and Beyond

Gravesteijn, B., Krijkamp, E., Value Based Operation Room Triage team collaborators, van Alphen, A., Busschbach, J., Geleijnse, G., Helmrich, I. R., Bruinsma, S., van Lint, C., van Veen, E., Steyerberg, E., Verhoef, C., van Saase, J., Lingsma, H. & Baatenburg de Jong, R., May 2022, In: Value in Health. 25, 5, p. 785-786 2 p.

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Development of prognostic models for Health-Related Quality of Life following traumatic brain injury

Helmrich, I. R. A. R., van Klaveren, D., Dijkland, S. A., Lingsma, H. F., Polinder, S., Wilson, L., von Steinbuechel, N., van der Naalt, J., Maas, A. I. R., Steyerberg, E. W., CENTER-TBI collaborators & Kompanje, E., Feb 2022, In: Quality of Life Research. 31, 2, p. 451-471 21 p.

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16 Citations (Scopus)

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Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

Galimberti, S., Graziano, F., CENTER-TBI and TRACK-TBI participants and investigators, Maas, A. I. R., Isernia, G., Lecky, F., Jain, S., Sun, X., Gardner, R. C., Taylor, S. R., Markowitz, A. J., Manley, G. T., Valsecchi, M. G., Bellelli, G., Citerio, G., Ackerlund, C., Adams, H., Amrein, K., Andelic, N. & Andreassen, L. & 31 others, Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., Foks, K., Gravesteijn, B., Haagsma, J. A., Haitsma, I., Huijben, J., Kompanje, E., Lingsma, H., Mikolic, A., Nieboer, D., Pisica, D., Polinder, S., Retel Helmrich, I., Sewalt, C., Singh, R. D., Steyerberg, E. W., Tibboel, D., van der Jagt, M., van Essen, T. A., van Veen, E., Velt, K., Volovici, V., Voormolen, D., Wiegers, E. & Schneider, A., Feb 2022, In: The Lancet Neurology. 21, 2, p. 153-162 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

42 Citations (Scopus)

2021

Prognostic Research in Traumatic Brain Injury: Markers, Modeling, and Methodological Principles

Helmrich, I. R. A. R., Lingsma, H. F., Turgeon, A. F., Yamal, J. M. & Steyerberg, E. W., 15 Sept 2021, In: Journal of Neurotrauma. 38, 18, p. 2502-2513 12 p.

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