Jan von der Thüsen

GEN-COVID Multicenter Study Group, Stanelle-Bertram, S., Beck, S., Mounogou, N. K., Schaumburg, B., Stoll, F., Al Jawazneh, A., Schmal, Z., Bai, T., Zickler, M., Beythien, G., Becker, K., de la Roi, M., Heinrich, F., Schulz, C., Sauter, M., Krasemann, S., Lange, P., Heinemann, A., van Riel, D., & 31 othersLeijten, L., Bauer, L., van den Bosch, T. P. P., Lopuhaä, B., Busche, T., Wibberg, D., Schaudien, D., Goldmann, T., Lüttjohann, A., Ruschinski, J., Jania, H., Müller, Z., Pinho dos Reis, V., Krupp-Buzimkic, V., Wolff, M., Fallerini, C., Baldassarri, M., Furini, S., Norwood, K., Käufer, C., Schützenmeister, N., von Köckritz-Blickwede, M., Schroeder, M., Jarczak, D., Nierhaus, A., Welte, T., Kluge, S., McHardy, A. C., Sommer, F., Kalinowski, J. & von der Thüsen, J., 19 Sept 2023, In: Cell Reports Medicine. 4, 9, 101152.

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Engineering of pulmonary surfactant corona on inhaled nanoparticles to operate in the lung system

Falahati, M., Hasan, A., Zeinabad, H. A., Serpooshan, V., von der Thüsen, J. H. & ten Hagen, T. L. M., 16 Sept 2023, (E-pub ahead of print) In: Nano Today. 52, 17 p., 101998.

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Epicardial fat volume is related to the degree of cardiac allograft vasculopathy

Roest, S., Budde, R. P. J., Brugts, J. J., von der Thusen, J., van Walsum, T., Taverne, Y. J. H. J., Zijlstra, F., Bos, D. & Manintveld, O. C., Jan 2023, In: European Radiology. 33, 1, p. 330-338 9 p.

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European Epidemiology of Pleural Mesothelioma—Real-Life Data From a Joint Analysis of the Mesoscape Database of the European Thoracic Oncology Platform and the European Society of Thoracic Surgery Mesothelioma Database

Opitz, I., Bille, A., ETOP Mesoscape and ESTS Consortia, Dafni, U., Nackaerts, K., Ampollini, L., de Perrot, M., Brcic, L., Nadal, E., Syrigos, K., Gray, S. G., Aerts, J., Curioni-Fontecedro, A., Rüschoff, J. H., Monkhorst, K., Weynand, B., Silini, E. M., Bavaghar-Zaeimi, F., Jakopovic, M., Llatjos, R., & 11 othersTsimpoukis, S., Finn, S. P., Thüsen, J. V. D., Marti, N., Dimopoulou, G., Kammler, R., Peters, S., Stahel, R. A., Falcoz, P. E., Brunelli, A. & Baas, P., Sept 2023, In: Journal of Thoracic Oncology. 18, 9, p. 1233-1247 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Feasibility and Potential of Transcriptomic Analysis Using the NanoString nCounter Technology to Aid the Classification of Rejection in Kidney Transplant Biopsies

Varol, H., Ernst, A., Cristoferi, I., Arns, W., Baan, C. C., van Baardwijk, M., van den Bosch, T., Eckhoff, J., Harth, A., Hesselink, D. A., van Kemenade, F. J., de Koning, W., Kurschat, C., Minnee, R. C., Mustafa, D. A. M., Reinders, M. E. J., Shahzad-Arshad, S. P., Snijders, M. L. H., Stippel, D., Stubbs, A. P., & 4 othersvon der Thüsen, J., Wirths, K., Becker, J. U. & Clahsen-van Groningen, M. C., 1 Apr 2023, In: Transplantation. 107, 4, p. 903-912 10 p.

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Impact of centralization of care for malignant peritoneal mesothelioma: A historical cohort study from the Dutch mesothelioma expert centers

van Kooten, J. P., de Gooijer, C. J., von der Thüsen, J. H., Brandt-Kerkhof, A. R. M., Albers, A. G. J., Lahaye, M. J., Monkhorst, K., Burgers, J. A., Aerts, J. G. J. V., Verhoef, C. & Madsen, E. V. E., Mar 2023, In: European Journal of Surgical Oncology. 49, 3, p. 611-618 8 p.

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Increase of Mast Cells in COVID-19 Pneumonia may Contribute to Pulmonary Fibrosis and Thrombosis

Wismans, L. V., Lopuhaä, B., de Koning, W., Moeniralam, H., van Oosterhout, M., Ambarus, C., Hofman, F. N., Kuiken, T., Endeman, H., Mustafa, D. A. M. & von der Thüsen, J. H., Feb 2023, In: Histopathology. 82, 3, p. 407-419 13 p.

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4 Citations (Scopus)

Molecular alterations and potential actionable mutations in peritoneal mesothelioma: a scoping review of high-throughput sequencing studies

Dietz, M. V., van Kooten, J. P., Paats, M. S., Aerts, J. G. V. J., Verhoef, C., Madsen, E. V. E., Dubbink, H. J. & von der Thüsen, J. H., Aug 2023, In: ESMO Open. 8, 4, 101600.

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Phenotypic variability of filamin C–related cardiomyopathy: Insights from a novel Dutch founder variant

Schoonvelde, S. A. C., Ruijmbeek, C. W. B., Hirsch, A., van Slegtenhorst, M. A., Wessels, M. W., von der Thüsen, J. H., Baas, A. F., Stroeks, S. L. V. M., Verdonschot, J. A. J., van der Zwaag, P. A., Verhagen, J. M. A. & Michels, M., 9 Aug 2023, (E-pub ahead of print) In: Heart Rhythm. 10 p.

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Prevalence, clinical and molecular characteristics of early stage EGFR-mutated lung cancer in a real-life West-European cohort: Implications for adjuvant therapy

Hondelink, L. M., Ernst, S. M., Atmodimedjo, P., Cohen, D., Wolf, J. L., Dingemans, A. M. C., Dubbink, H. J. & von der Thüsen, J. H., Mar 2023, In: European Journal of Cancer. 181, p. 53-61 9 p.

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Systematic review and meta-analysis of the prognostic impact of lymph node micrometastasis and isolated tumour cells in patients with stage I–IIIA non-small cell lung cancer

Hüyük, M., Fiocco, M., Postmus, P. E., Cohen, D. & von der Thüsen, J. H., Apr 2023, In: Histopathology. 82, 5, p. 650-663 14 p.

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The mast cell: A Janus in kidney transplants

van der Elst, G., Varol, H., Hermans, M., Baan, C. C., Duong-van Huyen, J. P., Hesselink, D. A., Kramann, R., Rabant, M., Reinders, M. E. J., von der Thüsen, J. H., van den Bosch, T. P. P. & Clahsen-van Groningen, M. C., 20 Feb 2023, In: Frontiers in Immunology. 14, 1122409.

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The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository

Henkens, M. T. H. M., van Ast, J. F., te Riele, A. S. J. M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M. T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W. M., Silljé, H. H. W., Jukema, J. W. & Doevendans, P. A., Jan 2023, In: Netherlands Heart Journal. 31, 1, p. 16-20 5 p.

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The value of prognostic and predictive parameters in early-stage lung adenocarcinomas: A comparison between biopsies and resections

Wolf, J. L., Trandafir, T. E., Akram, F., Andrinopoulou, E. R., Maat, A. W. P. M., Mustafa, D. A. M., Kros, J. M., Stubbs, A. P., Dingemans, A. C. & von der Thüsen, J. H., Feb 2023, In: Lung Cancer. 176, p. 112-120 9 p.

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Thymic neuroendocrine tumours

von der Thüsen, J., Feb 2023, In: Diagnostic Histopathology. 29, 2, p. 114-120 7 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Tobacco Smoking-Related Mutational Signatures in Classifying Smoking-Associated and Nonsmoking-Associated NSCLC

Ernst, S. M., Mankor, J. M., van Riet, J., von der Thüsen, J. H., Dubbink, H. J., Aerts, J. G. J. V., de Langen, A. J., Smit, E. F., Dingemans, A. M. C. & Monkhorst, K., Apr 2023, In: Journal of Thoracic Oncology. 18, 4, p. 487-498 12 p.

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2022

A case with two faces: noncompaction or phospholamban cardiomyopathy?

Wijchers, S., von der Thüsen, J. H., Robertus, J. L. & Caliskan, K., 1 Mar 2022, In: Cardiovascular Pathology. 57, 107395.

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Constitutive programmed death ligand 1 expression protects gastric G-cells from Helicobacter pylori–induced inflammation

Mommersteeg, M. C., Yu, B. T., van den Bosch, T. P. P., von der Thüsen, JH., Kuipers, E. J., Doukas, M., Spaander, MC. W., Peppelenbosch, M. P. & Fuhler, G. M., Oct 2022, In: Helicobacter. 27, 5, e12917.

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COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic

Fortarezza, F., Pezzuto, F., Hofman, P., Kern, I., Panizo, A., von der Thüsen, J., Timofeev, S., Gorkiewicz, G., Berezowska, S., de Level, L., Ortiz-Villalón, C., Lunardi, F. & Calabrese, F., 1 Jan 2022, In: Diagnostics. 12, 1, 95.

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Development and validation of a supervised deep learning algorithm for automated whole-slide programmed death-ligand 1 tumour proportion score assessment in non-small cell lung cancer

Hondelink, L. M., Hüyük, M., Postmus, P. E., Smit, V. T. H. B. M., Blom, S., von der Thüsen, J. H. & Cohen, D., Mar 2022, In: Histopathology. 80, 4, p. 635-647 13 p.

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Development and verification of new monoclonal orthopedia homeobox (OTP) specific antibodies for pulmonary carcinoid diagnostics

Moonen, L., Derks, J. L., Lap, L. M. V., Marijnissen, B. J. C. A., Hillen, L. M., den Bakker, M. A., von der Thüsen, J. H., van Suylen, R. J., Timens, W., Bintanel, M., Kuteeva, E., Dingemans, A. M. C. & Speel, E. J. M., 29 Nov 2022, In: Translational Lung Cancer Research. 11, 11, p. 2181-2191 11 p.

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Donor-Derived Cell-Free DNA for the Detection of Heart Allograft Injury: The Impact of the Timing of the Liquid Biopsy

Verhoeven, J. G. H. P., Hesselink, D. A., Peeters, A. M. A., de Jonge, E., von der Thüsen, J. H., van Schaik, R. H. N., Matic, M., Baan, C. C., Manintveld, O. C. & Boer, K., 21 Mar 2022, In: Transplant International. 35, 10122.

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Ensure: Dendritic cell therapy (MesoPher) in combination with extended-pleurectomy/decortication after chemotherapy in subjects with resectable mesothelioma: A feasibility study

Cantini, L., Dietz, M. V., Belderbos, R. A., Cornelissen, R., Dumoulin, D. W., Vink, M., Bezemer, K., Langerak, A. W., von der Thusen, J., Mahtab, E. A. F., Maat, L. P. W. M., Stadhouders, R., Hendriks, R., Willemsen, M. & Aerts, J. G., Sept 2022, In: Annals of Oncology. 33, 7, p. S1292-S1292 1 p.

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Evidence for a Role of CCR6+ T Cells in Chronic Thromboembolic Pulmonary Hypertension

van Uden, D., Koudstaal, T., van Hulst, J. A. C., van den Bosch, T. P. P., Vink, M., Bergen, I. M., Lila, K. A., van den Bosch, A. E., Bresser, P., Kool, M., von der Thüsen, J. H., Hendriks, R. W. & Boomars, K. A., 27 Apr 2022, In: Frontiers in Immunology. 13, 861450.

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Exercise in lung Cancer, the healthcare providers opinion (E.C.H.O.): Results of the EORTC lung cancer Group (LCG) survey

Pilotto, S., Avancini, A., Menis, J., Sperduti, I., Giaj Levra, M., Berghmans, T., Bironzo, P., Brandão, M., De Ruysscher, D., Edwards, J., Faivre-Finn, C., Girard, N., Greillier, L., Hendriks, L., Lantuejoul, S., Mauer, M., Novello, S., O'Brien, M., Reck, M., Reguart, N., & 5 othersRemon, J., von der Thüsen, J., Dingemans, A. M. C., Besse, B. & Milella, M., 1 Jul 2022, In: Lung Cancer. 169, p. 94-101 8 p.

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Expression of phosphorylated ribosomal protein S6 in mesothelioma patients-correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project

Rueschoff, J. H., Haberecker, M., ETOP Mesoscape Consortium, Tsourti, Z., Nackaerts, K., de Perrot, M., Brcic, L., Nadal, E., Tsimpoukis, S., Gray, S. G., Ampollini, L., Aerts, J. G., Felley-Bosco, E., Kirschner, M. B., Monkhorst, K., Weynand, B., Bavaghar-Zaeimi, F., Samarzija, M., Llatjos, R., Finn, S. P., & 9 othersSilini, E., von der Thusen, J., Marti, N., Vervita, K., Kammler, R., Peters, S., Stahel, R. A., Baas, P. & Opitz, I., 1 Dec 2022, In: Modern Pathology. 35, 12, p. 1888-1899 12 p.

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Immune suppression in the tumor-draining lymph node corresponds with distant disease recurrence in patients with melanoma

van Krimpen, A., Gerretsen, V. I. V., Mulder, E. E. A. P., van Gulijk, M., van den Bosch, T. P. P., von der Thüsen, J., Grünhagen, D. J., Verhoef, C., Mustafa, D., Aerts, J. G., Stadhouders, R. & Dammeijer, F., 8 Aug 2022, In: Cancer Cell. 40, 8, p. 798-799 2 p.

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9 Citations (Scopus)

Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

Van Kooten, J. P., Belderbos, R. A., Von Der Thüsen, J. H., Aarts, M. J., Verhoef, C., Burgers, J. A., Baas, P., Aalbers, A. G. J., Maat, A. P. W. M., Aerts, J. G. J. V., Cornelissen, R. & Madsen, E. V. E., 15 Nov 2022, (E-pub ahead of print) In: Thorax. 77, 12, 217709.

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In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma

PALGA-group, Hermans, B. C. M., Derks, J. L., Hillen, L. M., van der Baan, I., van den Broek, E. C., von der Thüsen, J. H., van Suylen, R. J., Atmodimedjo, P. N., den Toom, T. D., Coumans-Stallinga, C., Timens, W., Dinjens, W. N. M., Dubbink, H. J., Speel, E. J. M. & Dingemans, A. M. C., 1 Mar 2022, In: International Journal of Cancer. 150, 5, p. 802-815 14 p.

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Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis

Sklepkiewicz, P., Dymek, B. A., Mlacki, M., Koralewski, R., Mazur, M., Nejman-Gryz, P., Korur, S., Zagozdzon, A., Rymaszewska, A., von der Thüsen, J. H., Siwińska, A. M., Güner, N. C., Cheda, Ł., Paplinska-Goryca, M., Proboszcz, M., van den Bosch, T. P. P., Górska, K., Golab, J., Kamiński, R. M., Krenke, R., & 3 othersGolebiowski, A., Dzwonek, K. & Dobrzanski, P., 15 Mar 2022, In: European Journal of Pharmacology. 919, 174792.

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Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal

Calabrese, F., Roden, A. C., Pavlisko, E., Lunardi, F., Neil, D., Adam, B., Hwang, D., Goddard, M., Berry, G. J., Ivanovic, M., Thüsen, J. V. D., Gibault, L., Lin, C. Y., Wassilew, K., Glass, C., Westall, G., Zeevi, A., Levine, D. J. & Roux, A., 1 Oct 2022, In: Journal of Heart and Lung Transplantation. 41, 10, p. 1487-1500 14 p.

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Molecular pathology testing for non-small cell lung cancer: an observational study of elements currently present in request forms and result reports and the opinion of different stakeholders

Dufraing, K., Van Casteren, K., Breyne, J., D’Haene, N., Van Campenhout, C., Vander Borght, S., Zwaenepoel, K., Rouleau, E., Schuuring, E., von der Thüsen, J. & Dequeker, E., 6 Jul 2022, In: BMC Cancer. 22, 1, 736.

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Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease

Verhagen, J. M. A., Burger, J., Bekkers, J. A., Den Dekker, A. T., von der Thüsen, J. H., Zajec, M., Brüggenwirth, H. T., van der Sterre, M. L. T., van den Born, M., Luider, T. M., van IJcken, W. F. J., Wessels, M. W., Essers, J., Roos-Hesselink, J. W., van der Pluijm, I., van de Laar, I. M. B. H. & Brosens, E., Jan 2022, In: International Journal of Molecular Sciences. 23, 1, 438.

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Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing

Pruis, M. A., Groenendijk, F. H., Badloe, K. S., van Puffelen, A., Robbrecht, D., Dinjens, W. N. M., Sleijfer, S., Dingemans, A. M. C., von der Thüsen, J. H., Roepman, P. & Lolkema, M. P., 1 Sept 2022, In: British Journal of Cancer. 127, 4, p. 776-783 8 p.

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Pharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis

Dymek, B., Sklepkiewicz, P., Mlacki, M., Güner, N. C., Nejman-Gryz, P., Drzewicka, K., Przysucha, N., Rymaszewska, A., Paplinska-Goryca, M., Zagozdzon, A., Proboszcz, M., Krzemiński, Ł., von der Thüsen, J. H., Górska, K., Dzwonek, K., Zasłona, Z., Dobrzanski, P. & Krenke, R., 29 Sept 2022, In: Journal of Inflammation Research. 15, p. 5621-5634 14 p.

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Quantitative CT imaging analysis to predict pathology features in patients with a Congenital Pulmonary Airway Malformation

Hermelijn, S. M., Mackenbach, M. J., van Horik, C., Ciet, P., Wolf, J. L., von der Thüsen, J. H., Wijnen, R. M. H., Tiddens, H. A. W. M. & Schnater, J. M., Aug 2022, In: Journal of Pediatric Surgery. 57, 8, p. 1567-1572 6 p.

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The impact of a pathologist's personality on the interobserver variability and diagnostic accuracy of predictive PD-L1 immunohistochemistry in lung cancer

Butter, R., Hondelink, L. M., van Elswijk, L., Blaauwgeers, J. L. G., Bloemena, E., Britstra, R., Bulkmans, N., van Gulik, A. L., Monkhorst, K., de Rooij, M. J., Slavujevic-Letic, I., Smit, V. T. H. B. M., Speel, E. J. M., Thunnissen, E., von der Thüsen, J. H., Timens, W., van de Vijver, M. J., Yick, D. C. Y., Zwinderman, A. H., Cohen, D., & 2 others't Hart, N. A. & Radonic, T., Apr 2022, In: Lung Cancer. 166, p. 143-149 7 p.

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2021

Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course

Miedema, J., Schreurs, M., van der Sar – van der Brugge, S., Paats, M., Baart, S., Bakker, M., Hoek, R., Dik, W. A., Endeman, H., Van Der Velden, V., van Gammeren, A., Ermens, A., Aerts, J. G. & Thüsen, J. V. D., 13 May 2021, In: Frontiers in Immunology. 12, 684142.

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Case report: a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia

von der Thüsen, J. H., van Bommel, J., Kros, J. M., Verdijk, R. M., Lopuhaä, B., Lam, K. H., Dik, W. A. & Miedema, J. R., Mar 2021, In: Journal of Hematopathology. 14, 1, p. 79-83 5 p.

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Central role of dendritic cells in pulmonary arterial hypertension in human and mice

Uden, D., Koudstaal, T., van Hulst, J., Bergen, I., Gootjes, C., Morrell, NW., van Loo, G., von der Thüsen, J., van den Bosch, T., Ghigna, MR., Perros, F., Montani, D., Kool, M., Boomars, K. & Hendriks, R., 10 Feb 2021, In: International Journal of Molecular Sciences. 22, 4, p. 1-19 19 p., 1756.

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Clinical-Pathologic Challenges in the Classification of Pulmonary Neuroendocrine Neoplasms and Targets on the Horizon for Future Clinical Practice

Derks, J. L., Rijnsburger, N., Hermans, B. C. M., Moonen, L., Hillen, L. M., von der Thüsen, J. H., den Bakker, M. A., van Suylen, R. J., Speel, E. J. M. & Dingemans, A. M. C., 1 Oct 2021, In: Journal of Thoracic Oncology. 16, 10, p. 1632-1646 15 p.

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COVID-19-related myocarditis post-heart transplantation

Roest, S., Brugts, J. J., van Kampen, J. J. A., von der Thüsen, J. H., Constantinescu, A. A., Caliskan, K., Hirsch, A. & Manintveld, O. C., 1 Jun 2021, In: International Journal of Infectious Diseases. 107, p. 34-36 3 p.

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Current concepts in the classification of thoracic neuroendocrine tumours

von der Thüsen, J. H., Aug 2021, In: Diagnostic Histopathology. 27, 8, p. 336-343 8 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Defining oligometastatic non-small cell lung cancer: Concept versus biology, a literature review

Mentink, J. F., Paats, M. S., Dumoulin, D. W., Cornelissen, R., Elbers, J. B. W., Maat, A. P. W. M., Von Der Thüsen, J. H. & Dingemans, A. M. C., 1 Jul 2021, In: Translational Lung Cancer Research. 10, 7, p. 3329-3338 10 p.

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9 Citations (Scopus)

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Endobronchial ultrasound in diagnosing and staging of lung cancer by Acquire 22G TBNB versus regular 22G TBNA needles: Study protocol of a randomised clinical trial

Kuijvenhoven, J. C., Kramer, T., Korevaar, D. A., Ninaber, M. K., Trisolini, R., Szlubowski, A., Gnass, M., von der Thüsen, J. H., Cohen, D., Bonta, P. I. & Annema, J. T., 2 Sept 2021, In: BMJ Open. 11, 9, 6 p., e051820.

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ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

von der Thüsen, J. H., Dumoulin, D. W., Maat, A. P. W. M., Wolf, J., Sadeghi, A. H., Aerts, J. G. J. V. & Cornelissen, R., Jun 2021, In: Lung Cancer. 156, p. 72-75 4 p.

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5 Citations (Scopus)

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dr. Jan von der Thüsen

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