Drs Johan van den Akker

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• 2024

  Presence of procoagulant peripheral blood mononuclear cells in severe COVID-19 patients relate to ventilation perfusion mismatch and precede pulmonary embolism

  Dutch Covid-19 and Thrombosis Coalition (DCTC), Raadsen, M., Langerak, T., Du Toit, J., Kruip, M. J. H. A., Aynekulu Mersha, D., De Maat, M. P. M., Vermin, B., Van den Akker, J. P. C., Schmitz, K. S., Bakhtiari, K., Meijers, J. C. M., van Gorp, E. C. M., Short, K. R., Haagmans, B., de Vries, R. D., Gommers, D. A. M. P. J., Endeman, H. & Goeijenbier, M., 1 Feb 2024, In: Journal of Critical Care. 79, 154463.

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  • Pulmonary Embolism 100%
  • Procoagulant 100%
  • COVID-19 100%
  • Peripheral Blood Mononuclear Cell 100%
  • Thromboplastin 33%
  2 Citations (Scopus)

  13 Downloads (Pure)
• 2023

  Dynamics of Staphylococcus aureus in patients and the hospital environment in a tertiary care hospital in the Netherlands

  van der Schoor, A. S., Voor in ’t holt, A. F., Zandijk, W. H. A., Bruno, M. J., Gommers, D., van den Akker, J. P. C., Hendriks, J. M., Severin, J. A., Klaassen, C. H. W. & Vos, M. C., 20 Dec 2023, In: Antimicrobial Resistance and Infection Control. 12, 1, p. 1-10 10 p., 148.

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  • Tertiary Care 100%
  • Staphylococcus Aureus 100%
  • Dynamics 100%
  • Protein A 66%
  • Methicillin Resistant Staphylococcus Aureus 16%
  1 Citation (Scopus)

  25 Downloads (Pure)

• Universal screening or a universal risk assessment combined with risk-based screening for multidrug-resistant microorganisms upon admission: Comparing strategies

  van der Schoor, A. S., Severin, J. A., Klaassen, C. H. W., van den Akker, J. P. C., Bruno, M. J., Hendriks, J. M., Vos, M. C. & Voor In 't Holt, A. F., 25 Jul 2023, In: PLoS ONE. 18, 7 July, e0289163.

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  • Observational Study 100%
  • Prospective Cohort Study 100%
  • Electronic Health Record 100%
  • Extended Spectrum Beta Lactamase 100%
  • Extended Spectrum Beta Lactamase Producing Enterobacteriaceae 100%
  2 Citations (Scopus)

  11 Downloads (Pure)

• Levels of Fibrinogen Variants Are Altered in Severe COVID-19

  de Vries, J. J., Visser, C., van Ommen, M., Rokx, C., van Nood, E., van Gorp, E. C. M., Goeijenbier, M., van den Akker, J. P. C., Endeman, H., Rijken, D. C., Kruip, M. J. H. A., Weggeman, M., Koopman, J. & de Maat, M. P. M., Jul 2023, In: TH open : companion journal to thrombosis and haemostasis. 7, 3, p. e217-e225

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  • Coronavirinae 100%
  • Fibrinogen Variant 100%
  • Diseases 100%
  • Fibrinogen 100%
  • Thrombosis 54%
  10 Downloads (Pure)
• 2022

  The effect of 100% single-occupancy rooms on acquisition of extended-spectrum beta-lactamase-producing Enterobacterales and intra-hospital patient transfers: a prospective before-and-after study

  van der Schoor, A. S., Severin, J. A., van der Weg, A. S., Strepis, N., Klaassen, C. H. W., van den Akker, J. P. C., Bruno, M. J., Hendriks, J. M., Vos, M. C. & Voor in ’t holt, A. F., Dec 2022, In: Antimicrobial Resistance and Infection Control. 11, 1, 76.

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  • Patient Transport 100%
  • Extended Spectrum Beta Lactamase 100%
  • Beta-Lactamase 100%
  • Enterobacterales 100%
  • Hospital Building 27%
  12 Citations (Scopus)

  27 Downloads (Pure)

• Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis

  de Vries, J. J., Visser, C., Geers, L., Slotman, J. A., van Kleef, N. D., Maas, C., Bax, H. I., Miedema, J. R., van Gorp, E. C. M., Goeijenbier, M., van den Akker, J. P. C., Endeman, H., Rijken, D. C., Kruip, M. J. H. A. & de Maat, M. P. M., Jun 2022, In: Journal of Thrombosis and Haemostosis. 20, 6, p. 1412-1420 9 p.

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  • Thrombosis 100%
  • Fibrinolysis 100%
  • COVID-19 100%
  • Intensive Care Unit 100%
  • Coronavirinae 100%
  8 Citations (Scopus)

  78 Downloads (Pure)

• Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19

  Raadsen, M. P., Gharbharan, A., Jordans, C. C. E., Mykytyn, A. Z., Lamers, M. M., van den Doel, P. B., Endeman, H., van den Akker, J. P. C., GeurtsvanKessel, C. H., Koopmans, M. P. G., Rokx, C., Goeijenbier, M., van Gorp, E. C. M., Rijnders, B. J. A. & Haagmans, B. L., Feb 2022, In: Journal of Clinical Immunology. 42, 2, p. 232-239 8 p.

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  • COVID-19 100%
  • Blood Plasma 100%
  • Autoantibodies 100%
  • Interferon Gamma 100%
  • Gamma Interferon 100%
  36 Citations (Scopus)

  14 Downloads (Pure)
• 2021

  Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19

  Aguilar-Bretones, M., Westerhuis, B. M., Raadsen, M. P., de Bruin, E., Chandler, F. D., Okba, N. M. A., Haagmans, B. L., Langerak, T., Endeman, H., van den Akker, J. P. C., Gommers, D. A. M. P. J., van Gorp, E. C. M., GeurtsvanKessel, C. H., de Vries, R. D., Fouchier, R. A. M., Rockx, B. H. G., Koopmans, M. P. G. & van Nierop, G. P., 1 Nov 2021, In: Journal of Clinical Investigation. 131, 21, 14 p., e150613.

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  • COVID-19 100%
  • Cross-Reactivity 100%
  • B Cell 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Coronavirinae 100%
  43 Citations (Web of Science)

  72 Downloads (Pure)

• Increased number of positive coagulase-negative staphylococci in blood cultures is partly explained by increased use of intra-arterial catheters in patients with COVID-19

  Yusuf, E., de Haan, J. E., van den Akker, J. P. C., Vogel, M., de Steenwinkel, J. E. M., Rijnders, B. J. A. & Bode, L. G. M., 1 Sept 2021, In: Journal of Hospital Infection. 115, p. 126-127 2 p.

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  Open Access

• High Levels of Neutrophil Extracellular Traps Persist in the Lower Respiratory Tract of Critically Ill Patients with Coronavirus Disease 2019

  Ouwendijk, W. J. D., Raadsen, M. P., Van Kampen, J. J. A., Verdijk, R. M., Von Der Thusen, J. H., Guo, L., Hoek, R. A. S., Van Den Akker, J. P. C., Endeman, H., Langerak, T., Molenkamp, R., Gommers, D., Koopmans, M. P. G., Van Gorp, E. C. M., Verjans, G. M. G. M. & Haagmans, B. L., 1 May 2021, In: Journal of Infectious Diseases. 223, 9, p. 1512-1521 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Respiratory Tract 100%
  • Coronavirinae 100%
  • Diseases 100%
  • Neutrophil 100%
  • Lower Respiratory Tract 100%
  50 Citations (Scopus)

• Temporal Kinetics of RNAemia and Associated Systemic Cytokines in Hospitalized COVID-19 Patients

  van Riel, D., Embregts, C. W. E., Sips, G., van den Akker, J. P. C., Endeman, H., van Nood, E., Raadsen, M., Bauer, L., van Kampen, J., Molenkamp, R., Koopmans, M., van de Vijver, D. & GeurtsvanKessel, C. H., May 2021, In: mSphere. 6, 3, e00311-21.

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  • COVID-19 100%
  • Cytokine 100%
  • Diseases 100%
  • Chemokine 50%
  • Virus RNA 37%
  12 Citations (Scopus)

  84 Downloads (Pure)

• Frequency of Positive Aspergillus Tests in COVID-19 Patients in Comparison to Other Patients with Pulmonary Infections Admitted to the Intensive Care Unit

  Yusuf, E., Vonk, A., van den Akker, J., Bode, L., Sips, G., Rijnders, B., de Steenwinkel, J., Verkaik, N., Vogel, M., van der Eerden, M. & van Westreenen, M., 18 Feb 2021, In: Journal of Clinical Microbiology. 59, 3, e02278-20.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Aspergillus 100%
  • Lung Infection 100%
  • COVID-19 100%
  • Intensive Care Unit 100%
  • Streptococcus Pneumonia 100%
  16 Citations (Scopus)

• Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

  van Kampen, J., van de Vijver, D., Fraaij, P., Haagmans, B., Lamers, M., Okba, N., van den Akker, J., Endeman, R., Gommers, D., Cornelissen, J., Hoek, R. A. S., van der Eerden, M., Hesselink, D., Metselaar, H., Verbon, A., de Steenwinkel, J., Aron, G., van Gorp, E., van Boheemen, S. & Kreeft - Voermans, J. & 5 others, Boucher, C., Molenkamp, R., Koopmans, M., Geurts van Kessel, C. & Baltissen - van der Eijk, A., 11 Jan 2021, In: Nature Communications. 12, 1, 267.

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  • Virus Infectivity 100%
  • Virus Shedding 100%
  • COVID-19 100%
  • Viral Shedding 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 50%
  511 Citations (Scopus)

  22 Downloads (Pure)
• 2020

  An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment

  Geurts van Kessel, C., Okba, N., Iglói, Z., Bogers, S., Embregts, C., Laksono, B., Leijten, L., Rokx, C., Rijnders, B., Rahamat-Langendoen, J., Akker, J., Kampen, J., Eijk, A., van Binnendijk, R., Haagmans, B. & Koopmans, M., 2020, In: Nature Communications. 11, 1, 3436.

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  275 Citations (Scopus)

  14 Downloads (Pure)

• Angiotensin-converting enzyme-2 in SARS-CoV-2 infection: good or bad?

  Versmissen, J., Verdonk, K., Lafeber, M., van den Akker, J., Hunfeld, N., Hoorn, E. & Danser, A., 2020, In: Journal of Hypertension. 38, 6, p. 1196-1197 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

  Weiskopf, D., Schmitz, K., Raadsen, M., Grifoni, A., Okba, N., Endeman, R., van den Akker, J., Molenkamp, R., Koopmans, M., van Gorp, E., Haagmans, B., de Swart, R., Sette, A. & de Vries, R., 2020, In: Science immunology. 5, 48, eabd2071.

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  677 Citations (Scopus)

  60 Downloads (Pure)

• Progressive respiratory failure in COVID-19: a hypothesis

  Endeman, R., van der Zee, P., van Genderen, M., van den Akker, J. & Gommers, D., 2020, In: The Lancet Infectious Diseases. 20, 12, p. 1365

  Research output: Contribution to journal › Article › Academic
  13 Citations (Scopus)
• 2019

  Massive diarrhoea and sepsis due to an infection with Neisseria meningitidis serogroup W

  Houweling, B., Meurs, S., Versluis, J., Grewal, S., Verkaik, N. & van den Akker, J., 2019, In: Netherlands Journal of Medicine. 77, 3, p. 116-118 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  5 Citations (Scopus)

• Risk indicators for acute kidney injury in cardiogenic shock

  van den Akker, J., Bakker, H., Groeneveld, J. & Uil, C., 2019, In: Journal of Critical Care. 50, p. 11-16 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  26 Citations (Scopus)
• 2016

  Obituary: Professor AB Johan Groeneveld

  van den Akker, J. & Gommers, D., 2016, In: Critical Care. 20, 365.

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  8 Downloads (Pure)
• 2013

  Do we need alternatives for bicarbonate and anion gap?

  van den Akker, J. & Groeneveld, J., 2013, In: Minerva Anestesiologica. 79, 10, p. 1111-1112 2 p.

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  1 Citation (Scopus)

• Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis

  van den Akker, J., Egal, M. & Groeneveld, J., 2013, In: Critical Care. 17, 3

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  190 Citations (Scopus)

  14 Downloads (Pure)
• 2012

  Medical-grade honey does not reduce skin colonization at central venous catheter-insertion sites of critically ill patients: a randomized controlled trial

  Kwakman, P., Muller, M., Binnekade, J., van den Akker, J., de Borgie, C., Schultz, M. & Zaat, S., 2012, In: Critical Care. 16, 5

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  16 Citations (Scopus)

  9 Downloads (Pure)