Jolanda Vaarwater

2024

Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status

Gelmi, M. C., de Ru, A. H., van Veelen, P. A., Tjokrodirijo, R. T. N., Stern, M. H., Houy, A., Verdijk, R. M., Vu, T. H. K., Ksander, B. R., Vaarwater, J., Kilic, E., Brosens, E. & Jager, M. J., Jul 2024, In: Investigative ophthalmology & visual science. 65, 8, 1 p., 37.

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1 Citation (Scopus)

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The Pediatric and Young Adult Choroidal and Ciliary Body Melanoma Genetic Study, A Survey by the European Ophthalmic Oncology Group

van Poppelen, N. M., Cassoux, N., Turunen, J. A., Naus, N. C., Verdijk, R. M., Vaarwater, J., Cohen, V., Papastefanou, V. P., Kiratli, H., Saakyan, S. V., Tsygankov, A. Y., Rospond-Kubiak, I., Mudhar, H. S., Salvi, S. M., Kiilgaard, J. F., Heegaard, S., Moulin, A. P., Saornil, M. A., Garciá-Alvarez, C. & Fili, M. & 6 others, Eide, N. A., Meyer, P., Kivela, T. T., de Klein, A., Kilic, E. & Al-Jamal, R. T., Apr 2024, In: Investigative Ophthalmology and Visual Science. 65, 4

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8q Gain Has No Additional Predictive Value in SF3B1^MUT Uveal Melanoma but Is Predictive for a Worse Prognosis in Patients with BAP1^MUT Uveal Melanoma

Nguyen, J. Q. N., Drabarek, W., Vaarwater, J., Yavuzyigitoglu, S., Verdijk, R. M., Pandaens, D., Naus, N. C., de Klein, A., Brosens, E., Kilic, E. & Rotterdam Ocular Melanoma Study Group (ROMS), 1 Mar 2024, In: Ophthalmology Science. 4, 2, 6 p., 100413.

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4 Citations (Scopus)

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2023

Uveal Melanoma Patients Have a Distinct Metabolic Phenotype in Peripheral Blood

de Bruyn, D. P., Bongaerts, M., Rotterdam Ocular Melanoma Study Group (ROMS), Bonte, R., Vaarwater, J., Meester-Smoor, M. A., Verdijk, R. M., Paridaens, D., Naus, N. C., de Klein, A., Ruijter, G. J. G., Kiliç, E. & Brosens, E., 7 Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 5077.

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1 Citation (Scopus)

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2022

Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal Melanoma

Drabarek, W., van Riet, J., Rotterdam Ocular Melanoma Study Group (ROMS), Nguyen, J. Q. N., Smit, K. N., van Poppelen, N. M., Jansen, R., Medico-Salsench, E., Vaarwater, J., Magielsen, F. J., Brands, T., Eussen, B., van den Bosch, T. P. P., Verdijk, R. M., Naus, N. C., Paridaens, D., de Klein, A., Brosens, E., van de Werken, H. J. G. & Kilic, E., 8 Feb 2022, In: Cancers. 14, 3, 846.

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16 Citations (Scopus)

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Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

Smit, K. N., Boers, R., Vaarwater, J., Boers, J., Brands, T., Mensink, H., Verdijk, R. M., van IJcken, W. F. J., Gribnau, J., de Klein, A. & Kilic, E., 7 Jan 2022, In: Scientific Reports. 12, 1, 42.

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19 Citations (Scopus)

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2021

Radiological patterns of uveal melanoma liver metastases in correlation to genetic status

Yavuzyigitoglu, S., Tang, M. C. Y., Jansen, M., Geul, K. W., Dwarkasing, R. S., Vaarwater, J., Drabarek, W., Verdijk, R. M., Paridaens, D., Naus, N. C., Brosens, E., de Klein, A. & Kilic, E., 1 Nov 2021, In: Cancers. 13, 21, 5316.

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5 Citations (Scopus)

116 Downloads (Pure)

Molecular genetics of conjunctival melanoma and prognostic value of tert promoter mutation analysis

van Poppelen, N. M., van Ipenburg, J. A., van den Bosch, Q., Vaarwater, J., Brands, T., Eussen, B., Magielsen, F., Dubbink, H. J., Paridaens, D., Brosens, E., Naus, N., de Klein, A., Kiliç, E. & Verdijk, R. M., 1 Jun 2021, In: International Journal of Molecular Sciences. 22, 11, 5784.

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23 Citations (Scopus)

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2019

Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis

Smit, K., Chang, J., Derks, K., Vaarwater, J., Brands, T., Verdijk, R., Wiemer, E., Mensink, H., Pothof, J., de Klein, A. & Kiliç, E., 2019, In: Cancers. 11, 6, E815.

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35 Citations (Scopus)

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Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients

Drabarek, W., Yavuzyigitoglu, S., Obulkasim, A., van Riet, J., Smit, K., van Poppelen, N., Vaarwater, J., Brands, T., Eussen, H., Verdijk, R., Naus, N., Mensink, H., Paridaens, D., Boersma, E., van de Werken, H., Kiliç, E., de Klein, A., Keizer, R., van Beek, J. & van Rij, C. & 3 others, Brosens, E., van Ipenburg, J. & de Bruyn, D., 2019, In: Investigative Ophthalmology & Visual Science. 60, 10, p. 3595-3605 11 p.

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12 Citations (Scopus)

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SRSF2 Mutations in Uveal Melanoma: A Preference for In-Frame Deletions?

van Poppelen, N., Drabarek, W., Smit, K., Vaarwater, J., Brands, T., Paridaens, D., Kiliç, E. & de Klein, A., 2019, In: Cancers. 11, 8, 1200.

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19 Citations (Scopus)

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2018

Chromosomal rearrangements in uveal melanoma: Chromothripsis

van Poppelen, N., Yavuzyigitoglu, S., Smit, K., Vaarwater, J., Eussen, H., Brands, T., Paridaens, D., Kiliç, E. & de Klein, A., 2018, In: Genes Chromosomes & Cancer. 57, 9, p. 452-458 7 p.

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5 Citations (Scopus)

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Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma

Smit, K., van Poppelen, N., Vaarwater, J., Verdijk, R., van Marion, R., Kalirai, H., Coupland, S. E., Thornton, S., Farquhar, N., Dubbink, E. J., Paridaens, D., de Klein, A. & Kiliç, E., 2018, In: Modern Pathology. 31, 5, p. 763-771 9 p.

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56 Citations (Scopus)

Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential

van Poppelen, N., Vaarwater, J., Mudhar, H., Sisley, K., Rennie, I. G., Rundle, P., Brands, T., van den Bosch, Q., Mensink, H., de Klein, A., Kiliç, E. & Verdijk, R., 2018, In: Ophthalmology. 125, 6, p. 904-912 9 p.

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43 Citations (Scopus)

Re: van Poppelen et al.: Genetic background of iris melanomas and iris melanocytic tumors of uncertain malignant potential (Ophthalmology. 2018; 125: 904-912) Reply

van Poppelen, N., Vaarwater, J., Mudhar, H., Sisley, K., van den Bosch, Q., de Klein, A., Kiliç, E. & Verdijk, R., 2018, In: Ophthalmology. 125, 11, p. E79-E80

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2017

Correlation of Gene Mutation Status with Copy Number Profile in Uveal Melanoma

Yavuzyigitoglu, S., Drabarek, W., Smit, K., van Poppelen, N., Koopmans, A., Vaarwater, J., Brands, T., Eussen, H., Dubbink, E. J., van Riet, J., van de Werken, H., Beverloo, B., Verdijk, R., Naus, N., Paridaens, D., Kiliç, E. & de Klein, A., 2017, In: Ophthalmology. 124, 4, p. 573-575 3 p.

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27 Citations (Scopus)

2016

Lipomatous Change in Uveal Melanoma: Histopathological, Immunohistochemical and Cytogenetic Analysis

Yavuzyigitoglu, S., Kiliç, E., Vaarwater, J., de Klein, A., Paridaens, D. & Verdijk, R., 2016, In: Ocular Oncology and Pathology. 2, 3, p. 133-135 3 p.

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8 Citations (Scopus)

Metastatic Disease in Polyploid Uveal Melanoma Patients Is Associated With BAP1 Mutations

Yavuzyigitoglu, S., Mensink, H., Smit, K., Vaarwater, J., Verdijk, R., Beverloo, B., Brüggenwirth, H., van Marion, R., Dubbink, E. J., Paridaens, D., Naus, N., de Klein, A. & Kiliç, E., 2016, In: Investigative Ophthalmology & Visual Science. 57, 4, p. 2232-2239 8 p.

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17 Citations (Scopus)

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Uveal Melanomas with SF3B1 Mutations A Distinct Subclass Associated with Late-Onset Metastases

Yavuzyigitoglu, S., Koopmans, A., Verdijk, R., Vaarwater, J., Eussen, H., van Bodegom, A., Paridaens, D., Kiliç, E. & de Klein, A., 2016, In: Ophthalmology. 123, 5, p. 1118-1128 11 p.

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225 Citations (Scopus)

2015

Metastatic disease in uveal melanoma: importance of a genetic profile?

van Beek, J., Koopmans, A., Vaarwater, J., Verdijk, R., de Klein, A., Naus, N. & Kiliç, E., 2015, In: Melanoma Research. 25, 5, p. 447-449 3 p.

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7 Citations (Scopus)

Risk factors associated with secondary enucleation after fractionated stereotactic radiotherapy in uveal melanoma

van den Bosch, T., Vaarwater, J., Verdijk, R., Muller, K., Kiliç, E., Paridaens, D., de Klein, A. & Naus, N., 2015, In: Acta Ophthalmologica. 93, 6, p. 555-560 6 p.

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17 Citations (Scopus)

2014

Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma

Koopmans, A., Verdijk, R., Brouwer, R., van den Bosch, T., van den Berg, M., Vaarwater, J., Kockx, C., Paridaens, D., Naus, N., Nellist, M., van Ijcken, W., Kiliç, E. & de Klein, A., 2014, In: Modern Pathology. 27, 10, p. 1321-1330 10 p.

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191 Citations (Scopus)

The Prognostic Value of Extraocular Extension in Relation to Monosomy 3 and Gain of Chromosome 8q in Uveal Melanoma

van Beek, J., Koopmans, A., Vaarwater, J., Rooi, J., Paridaens, D., Naus, N., de Klein, A., Verdijk, R. & Kiliç, E., 2014, In: Investigative Ophthalmology & Visual Science. 55, 3, p. 1284-1291 8 p.

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37 Citations (Scopus)

2013

Chemokine Receptor CCR7 Expression Predicts Poor Outcome in Uveal Melanoma and Relates to Liver Metastasis Whereas Expression of CXCR4 Is Not of Clinical Relevance

Bosch, T., Koopmans, A., Vaarwater, J., van den Berg, M., de Klein, A. & Verdijk, R., 2013, In: Investigative Ophthalmology & Visual Science. 54, 12, p. 7354-7361 8 p.

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31 Citations (Scopus)

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11

Koopmans, A., Vaarwater, J., Paridaens, D., Naus, N., Kiliç, E. & de Klein, A., 2013, In: British Journal of Cancer. 109, 2, p. 493-496 4 p.

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87 Citations (Scopus)

2012

Higher Percentage of FISH-Determined Monosomy 3 and 8q Amplification in Uveal Melanoma Cells relate to Poor Patient Prognosis

Bosch, T., van Beek, J., Vaarwater, J., Verdijk, R., Naus, N., Paridaens, D., de Klein, A. & Kiliç, E., 2012, In: Investigative Ophthalmology & Visual Science. 53, 6, p. 2668-2674 7 p.

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95 Citations (Scopus)

Multiplex ligation-dependent probe amplification equals fluorescence in-situ hybridization for the identification of patients at risk for metastatic disease in uveal melanoma

Vaarwater, J., Bosch, T., Mensink, H., van Kempen, C., Verdijk, R., Naus, N., Paridaens, D., Brüggenwirth, H., Kiliç, E. & de Klein, A., 2012, In: Melanoma Research. 22, 1, p. 30-37 8 p.

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37 Citations (Scopus)

2011

Chromosomal aberrations in iris melanomas

Mensink, H., Vaarwater, J., de Keizer, R., de Wolff-Rouendaal, D., Mooy, C., de Klein, A. & Paridaens, D., 2011, In: British Journal of Ophthalmology. 95, 3, p. 424-428 5 p.

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24 Citations (Scopus)

2009