dr. Leon van den Toorn

Search results

• 2023

  A comparison of the effectiveness of different doses of tocilizumab and sarilumab in the treatment of severe COVID-19: a natural experiment due to drug shortages

  Swets, M. C., Moss, R. J., Kor, F., Hilarius, D., Moes, D. J. A. R., Berkhout, W. EM., van den Toorn, L. M., van den Oever, N. C. G., de Valk, R., Rosendaal, F. R., Hunfeld, N., Groeneveld, G. H. & de Boer, M. G. J., Apr 2023, In: International Journal of Infectious Diseases. 129, p. 57-62 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Tocilizumab 100%
  • Interleukin 6 33%
  • Mortality 22%
  • Survival 22%
  • Death 22%
  2 Downloads (Pure)
• 2022

  Admissions to a large tertiary care hospital and Omicron BA.1 and BA.2 SARS-CoV-2 polymerase chain reaction positivity: primary, contributing, or incidental COVID-19

  Voor In 't Holt, A. F., Haanappel, C. P., Rahamat-Langendoen, J., Molenkamp, R., van Nood, E., van den Toorn, L. M., Peeters, R. P., van Rossum, A. M. C. & Severin, J. A., Sept 2022, In: International Journal of Infectious Diseases. 122, p. 665-668 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • COVID-19 100%
  • Patient 54%
  • Severe Acute Respiratory Syndrome Coronavirus 2 36%
  • Polymerase Chain Reaction 18%
  • Pediatrics Patient 18%
  4 Citations (Scopus)

• Peripheral Blood T Cells of Patients with IPAH Have a Reduced Cytokine-Producing Capacity

  van Uden, D., Koudstaal, T., van Hulst, J. A. C., Vink, M., van Nimwegen, M., van den Toorn, L. M., Chandoesing, P. P., van den Bosch, A. E., Kool, M., Hendriks, R. W. & Boomars, K. A., 10 Jun 2022, In: International Journal of Molecular Sciences. 23, 12, 6508.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Patient 100%
  • Cytokine 60%
  • T Cell 50%
  • T-Helper Cell 50%
  • Connective Tissue Disease 30%
  3 Citations (Scopus)

  9 Downloads (Pure)

• The evolution of survival of pulmonary arterial hypertension over 15 years

  Hendriks, P. M., Staal, D. P., van de Groep, L. D., van den Toorn, L. M., Chandoesing, P. P., Kauling, R. M., Mager, H. J., van den Bosch, A. E., Post, M. C. & Boomars, K. A., Oct 2022, In: Pulmonary Circulation. 12, 4, e12137.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Patient 100%
  • Pulmonary Hypertension 35%
  • Survival 35%
  • Time 25%
  • Transplantation 15%
  1 Citation (Scopus)

  13 Downloads (Pure)
• 2021

  Loss of immune homeostasis in patients with idiopathic pulmonary arterial hypertension

  Heukels, P., Corneth, O. B. J., Van Uden, D., Van Hulst, J. A. C., Van Den Toorn, L. M., Van Den Bosch, A. E., Wijsenbeek, M. S., Boomars, K. A., Kool, M. & Hendriks, R. W., 1 Dec 2021, In: Thorax. 76, 12, p. 1209-1218 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Pulmonary Hypertension 100%
  • Polycyclic Aromatic Hydrocarbon 46%
  • Bruton Tyrosine Kinase 38%
  • Patient 30%
  • B Cell 23%
  8 Citations (Scopus)

  3 Downloads (Pure)

• Plasma markers in pulmonary hypertension subgroups correlate with patient survival

  Koudstaal, T., van Uden, D., van Hulst, J. A. C., Heukels, P., Bergen, I. M., Geenen, L. W., Baggen, V. J. M., van den Bosch, A. E., van den Toorn, L. M., Chandoesing, P. P., Kool, M., Boersma, E., Hendriks, R. W. & Boomars, K. A., 4 May 2021, In: Respiratory Research. 22, 1, 137.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Patient 100%
  • Pulmonary Hypertension 73%
  • Survival 46%
  • Chronic Thromboembolic Pulmonary Hypertension 40%
  • CXCL9 40%
  17 Citations (Scopus)

• Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

  Ghofrani, HA., Gomez Sanchez, MA., Humbert, M., Pittrow, D., Simonneau, G., Gall, H., Grünig, E., Klose, H., Halank, M., Langleben, D., Snijder, RJ., Escribano Subias, P., Mielniczuk, LM., Lange, TJ., Vachiéry, JL., Wirtz, H., Helmersen, DS., Tsangaris, I., Barberá, JA., Pepke-Zaba, J., & 262 othersBoonstra, A., Rosenkranz, S., Ulrich, S., Steringer-Mascherbauer, R., Delcroix, M., Jansa, P., Šimková, I., Giannakoulas, G., Klotsche, J., Williams, E., Meier, C., Hoeper, MM., Caneva, J., Tuhay, G., Diez, M., Talavera, ML., Acosta, A., Vulcano, N., Bosio, M., Maldonado, L., Deleo, S., Melatini, L., Keogh, A., Kotlyar, E., Feenstra, J., Dwyer, N., Adams, H., Stevens, W., Steele, P., Proudman, S., Minson, R., Reeves, G., Lavender, M., Ng, B., MacKenzie, M., Barry, L., Gruenberger, M., Huber, C., Lang, I., Tilea, I., Sadushi-Kolici, R., Löffler-Ragg, J., Feistmantl, LT., Evrard, P., Louis, R., Guiot, J., Naldi, M., Pauw, M., Mehta, S., Camacho, RC., Tovar, PP., Londoño, A., Campo, F., Garcia, P., Lema, C., Orozco-Levi, M., Martinez, W., Gomez, JE., Nielsen-Kudsk, JE., Mellemkjaer, S., Anton, L., Altraja, A., Vihinen, T., Vasankari, T., Sitbon, O., Cottin, V., Têtu, L., Noël-Savina, E., Shearman, N., Tayler, S., Olzik, I., Kulka, C., Grimminger, J., Simon, M., Nolde, A., Oqueka, T., Harbaum, L., Egenlauf, B., Ewert, R., Schulz, C., Regotta, S., Kramer, T., Knoop-Busch, S., Gerhardt, F., Konstantinides, S., Pitsiou, G., Stanopoulos, I., Sourla, E., Mouratoglou, S., Karvounis, H., Pappas, A., Georgopoulos, D., Fanaridis, M., Mitrouska, I., Michalis, L., Pappas, K., Kotsia, A., Gaine, S., Vizza, CD., Manzi, G., Poscia, R., Badagliacca, R., Agostoni, P., Bruno, N., Farina, S., D'Alto, M., Argiento, P., Correra, A., Di Marco, GM., Cresci, C., Vannucchi, V., Torricelli, E., Garcea, A., Pesci, A., Sardella, L., Paciocco, G., Pane, F., D'Armini, AM., Pin, M., Grazioli, V., Massola, G., Sciortino, A., Prediletto, R., Bauleo, C., Airò, E., Ndreu, R., Pavlickova, I., Lunardi, C., Mulè, M., Farruggio, S., Costa, S., Galgano, G., Petruzzi, M., Luca, A., Lombardi, F., Roncon, L., Conte, L., Picariello, C., Wirtz, G., Alexandre, M., Vonk-Noordegraaf, A., van den Boogaard, H., Mager, J., Reesink, H., van den Toorn, L., Boomars, K., Andreassen, AK., Castro, G., Tania, G., Baptista, R., Marinho, A., Shiang, T., Oliveira, A., Coutinho, D., Sousa, J., Loureiro, MJ., Repolho, D., Martins Jesus, SM., Capinha, M., Agostinho, J., Cardoso, T., Rocha, A., Espinha, M., Ivanov, KI., Alexeeva, DE., Batalina, MV., Hegya, DV., Zvereva, TN., Avdeev, SN., Tsareva, NA., Galyavich, AS., Nikolaevich, BA., Filippov, EV., Yakovleva, OE., Pavlova, OB., Skripkina, ES., Martynyuk, TV., Bukatova, IF., Tregubova, AV., Platonov, DY., Kolomeytseva, TM., Al Dalaan, A., Abdelsayed, AA., Weheba, I., Saleemi, S., Sakkijha, H., Bohacekova, M., Valkovicova, T., Farkasova, I., Quezada, CA., Piccari, L., Blanco, I., Sebastian, L., Roman, A., Lopez, M., Otero, R., Elias, T., Jara, L., Asencio, I., Arjona, JJ., Almagro, RM., Cárdenas, SL., García, SA., Rodríguez, PV., Lopez, R., Garcia, A., Avilés, FF., De La Pava, S., Yotti, R., Peñate, GP., Marrero, FL., Cifrián Martínez, JM., Martinez-Meñaca, A., Alonso, LP., Rozas, SF., Fernandez, DI., Cuesta, VM., Söderberg, S., Bartfay, SE., Rundqvist, B., Alfetlawi, M., Wodlin, P., Schwarz, EI., Speich, R., Lador, F., Rochat, T., Gasche-Soccal, P., Hsu, CH., Lin, TH., Su, HM., Lai, WT., Chu, CY., Hsu, PC., Voon, WC., Yen, HW., Yih-Jer Wu, J., Wu, SH., Huang, WP., Fong, MC., Huang, CL., Kuo, PH., Lin, YH., Lin, JL., Hung, CS., Wu, CK., Sung, SH., Huang, WC., Cheng, CC., Kuo, SH., Wang, WH., Ho, WJ., Hsu, TS., Mutlu, B., Atas, H., Ongen, G., Un, Z., Okumus, G., Hanta, I., Corris, P., Peacock, A., Church, C. & Toshner, M., 1 Mar 2021, In: Respiratory Medicine. 178, 106220.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Riociguat 100%
  • Chronic Thromboembolic Pulmonary Hypertension 62%
  • Adverse Event 50%
  • Pneumonia 25%
  • Heart Failure 25%
  15 Citations (Scopus)

  5 Downloads (Pure)

• The longitudinal use of EmPHasis-10 and CAMPHOR questionnaire health-related quality of life scores in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

  Hendriks, P. M., van Thor, M. C. J., Wapenaar, M., Chandoesing, P., van den Toorn, L. M., van den Bosch, A. E., Post, M. C. & Boomars, K. A., 1 Sept 2021, In: Respiratory Medicine. 186, 106525.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Health 100%
  • Pulmonary Hypertension 83%
  • Quality of Life 66%
  • Inpatient 66%
  • Symptom 66%
  2 Citations (Scopus)
• 2019

  Scalp hair cortisol and testosterone levels in patients with sarcoidosis

  van Manen, M., Wester, VL., van Rossum, L., van den Toorn, L., Dorst, KY., de Rijke, Y. & Wijsenbeek - Lourens, M., 2019, In: PLoS One (online). 14, 6, e0215763.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  10 Citations (Scopus)

  11 Downloads (Pure)

• The Effects of a 10-wk Outpatient Pulmonary Rehabilitation Program on Exercise Performance, Muscle Strength, Soluble Biomarkers, and Quality of Life in Patients With Pulmonary Hypertension

  Koudstaal, T., Korver, M., van Ranst, D., Beesems, R., van den Toorn, L., van den Bosch, A., Chandoesing, P. & Boomars, K., 2019, In: Journal of Cardiopulmonary Rehabilitation and Prevention. 39, 6, p. 397-402 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)
• 2018

  Daily home spirometry to detect early steroid treatment effects in newly treated pulmonary sarcoidosis

  Broos, C., Korver, M., Looman, C., van Veen, J., van den Toorn, L., Overbeek, MJ., Grootenboers, M., Heller, R., Mostard, RL., Poell, L., Hoogsteden, H., Kool, M., Wijsenbeek - Lourens, M. & Blink, B., 2018, In: European Respiratory Journal. 51, 1, 1702089.

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)

• Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis

  Heukels, P., van Hulst, J., van Nimwegen, M., Boorsma, CE., Melgert, BN., van den Toorn, L., Boomars, K., Wijsenbeek - Lourens, M., Hoogsteden, H., von der Thüsen, J., Hendriks, R., Kool, M. & Blink, B., 2018, In: Respiratory Research. 19, 90.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  35 Citations (Scopus)

  5 Downloads (Pure)

• Needs, Perceptions and Education in Sarcoidosis: A Live Interactive Survey of Patients and Partners

  Moor, K., van Manen, M., van Hagen, P. M., Miedema, J., van den Toorn, L., Demirel, Y., Berendse, APC., van Laar, J. & Wijsenbeek - Lourens, M., 2018, In: Lung. 196, 5, p. 569-575 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  21 Citations (Scopus)

  8 Downloads (Pure)

• No evidence found for an association between prednisone dose and FVC change in newly-treated pulmonary sarcoidosis

  Broos, C., Poell, L., Looman, C., van Veen, J., Grootenboers, M., Heller, R., van den Toorn, L., Korver, M., Hoogsteden, H., Kool, M., Wijsenbeek - Lourens, M. & Blink, B., 2018, In: Respiratory Medicine. 138, p. S31-S37

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)
• 2016

  Adaption and validation of the Cambridge pulmonary hypertension outcome review (Camphor) for the Netherlands

  Korver, M., Twiss, J., Wagenaar, M., Seijkens, P., van den Toorn, L., Stepanous, J., Heaney, A., van den Bosch, A. & Boomars, K., 2016, In: Netherlands Heart Journal. 24, 6, p. 417-242 174 p.

  Research output: Contribution to journal › Article › Academic

• Lung Transplantation in Gaucher Disease A Learning Lesson in Trying to Avoid Both Scylla and Charybdis

  Nieuwenhuyzen - de Boer, G., van der Dussen, L., van den Toorn, L., den Bakker, MA., Hoek, R. A. S., Hesselink, D., Hollak, CEM. & Hal, PTW., 2016, In: Chest. 149, 1, p. E1-E5

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• VALIDATION OF THE KING'S SARCOIDOSIS QUESTIONNAIRE (KSQ) IN A DUTCH SARCOIDOSIS POPULATION

  van Manen, M., Korver, M., Strookappe, B., Drent, M., Elfferich, M., Vries, J., Gosker, HR., Birring, SS., Patel, AS., van den Toorn, L., Blink, B., Boomars, K., Hoitsma, E. & Wijsenbeek - Lourens, M., 2016, In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 33, 1, p. 75-82 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  18 Citations (Scopus)
• 2015

  Idiopathic pulmonary fibrosis: new insights

  Kraan, JW., Blink, B., van den Toorn, L., Bresser, P., van Beek, FT., Grutters, JC. & Wijsenbeek - Lourens, M., 2015, In: Nederlands Tijdschrift voor Geneeskunde. 159, A8148.

  Research output: Contribution to journal › Article › Academic

  2 Citations (Scopus)

• Management of recurrent malignant pleural effusions with a tunneled indwelling pleural catheter

  de Heer, M., Cornelissen, R., Hoogsteden, H. & van den Toorn, L., 2015, In: World Journal of Respirology. 5, 2, p. 135-139 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
• 2013

  "Tree in bud" attributable to organising pneumonia

  Bots, E., den Bakker, M., Wijsenbeek - Lourens, M., van den Toorn, L. & Blink, B., 2013, In: Thorax. 68, 4, p. 399-400 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)
• 2007

  Nasal nitric oxide in cystic fibrosis with and without humming

  Struben, VMD., Sewbalak, WV., Wieringa, M., Ree, L., van den Toorn, L., Bakker, M., Feenstra, L. & Jongste, J., 2007, In: European Journal of Clinical Investigation. 37, p. 140-144 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• The pressure mounts on lung dendritic cells

  Lambrecht, B. & van den Toorn, L., 2007, In: European Respiratory Journal. 29, 3, p. 435-437 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)
• 2005

  Benefit from anti-inflammatory treatment during clinical remission of atopic asthma

  van den Toorn, L., Prins, JB., Jongste, J., Leman, K., Mulder, PGH., Hoogsteden, H. & Overbeek, S., 2005, In: Respiratory Medicine. 99, 6, p. 779-787 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• Management of recurrent malignant pleural effusions with a chronic indwelling pleural catheter.

  van den Toorn, L., Schaap, EL., Surmont, VFM., Pouw, EM., van der Rijt, K. & Klaveren, RJ., 2005, In: Lung Cancer. 50, p. 123-127 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  76 Citations (Scopus)