dr. Leslie Sanderson

Search results

• 2023

  AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model

  Deng, R., Medico-Salsench, E., Nikoncuk, A., Ramakrishnan, R., Lanko, K., Kühn, N. A., van der Linde, H. C., Lor-Zade, S., Albuainain, F., Shi, Y., Yousefi, S., Capo, I., van den Herik, E. M., van Slegtenhorst, M., van Minkelen, R., Geeven, G., Mulder, M. T., Ruijter, G. J. G., Lütjohann, D., Jacobs, E. H., & 32 othersHoulden, H., Pagnamenta, A. T., Metcalfe, K., Jackson, A., Banka, S., De Simone, L., Schwaede, A., Kuntz, N., Palculict, T. B., Abbas, S., Umair, M., AlMuhaizea, M., Colak, D., AlQudairy, H., Alsagob, M., Pereira, C., Trunzo, R., Karageorgou, V., Bertoli-Avella, A. M., Bauer, P., Bouman, A., Hoefsloot, L. H., van Ham, T. J., Issa, M., Zaki, M. S., Gleeson, J. G., Willemsen, R., Kaya, N., Arold, S. T., Maroofian, R., Sanderson, L. E. & Barakat, T. S., 29 Apr 2023, (E-pub ahead of print) In: Acta Neuropathologica.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Zebra Fish 100%
  • Autosomal Recessive Inheritance 100%
  • Fibroblast 66%
  • Stem Cell 66%
  • Larva 66%
• 2022

  Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy

  Berdowski, W. M., van der Linde, H. C., Breur, M., Oosterhof, N., Beerepoot, S., Sanderson, L., Wijnands, L. I., de Jong, P., Tsai-Meu-Chong, E., de Valk, W., de Witte, M., van IJcken, W. F. J., Demmers, J., van der Knaap, M. S., Bugiani, M., Wolf, N. I. & van Ham, T. J., Aug 2022, In: Acta Neuropathologica. 144, 2, p. 211-239 29 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Microglia 100%
  • Brain 85%
  • Tumor Spheroid 71%
  • Glia 71%
  • Zebra Fish 57%
  4 Citations (Scopus)

  9 Downloads (Pure)
• 2021

  Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking

  Sanderson, L. E., Lanko, K., Alsagob, M., Almass, R., Al-Ahmadi, N., Najafi, M., Al-Muhaizea, M. A., Alzaidan, H., Aldhalaan, H., Perenthaler, E., Van Der Linde, H. C., Nikoncuk, A., Kühn, N. A., Antony, D., Owaidah, T. M., Raskin, S., Vieira, L. G. D. R., Mombach, R., Ahangari, N., Silveira, T. R. D., & 36 othersAmeziane, N., Rolfs, A., Alharbi, A., Sabbagh, R. M., Alahmadi, K., Alawam, B., Ghebeh, H., Alhargan, A., Albader, A. A., Binhumaid, F. S., Goljan, E., Monies, D., Mustafa, O. M., Aldosary, M., Albakheet, A., Alyounes, B., Almutairi, F., Al-Odaib, A., Aksoy, D. B., Basak, A. N., Palvadeau, R., Trabzuni, D., Rosenfeld, J. A., Karimiani, E. G., Meyer, B. F., Karakas, B., Al-Mohanna, F., Arold, S. T., Colak, D., Maroofian, R., Houlden, H., Bertoli-Avella, A. M., Schmidts, M., Barakat, T. S., Van Ham, T. J. & Kaya, N., 1 Mar 2021, In: Brain. 144, 3, p. 769-780 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Ataxia 100%
  • Protein Function 100%
  • Disease Modeling 100%
  • Transport Protein 100%
  • Membrane 100%
  22 Citations (Scopus)

  21 Downloads (Pure)

• Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease

  Sofou, K., Meier, K., Sanderson, L. E., Kaminski, D., Montoliu-Gaya, L., Samuelsson, E., Blomqvist, M., Agholme, L., Gärtner, J., Mühlhausen, C., Darin, N., Barakat, T. S., Schlotawa, L., van Ham, T., Asin Cayuela, J. & Sterky, F. H., 3 May 2021, In: EMBO Molecular Medicine. 13, 5, e13376.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Mucopolysaccharidosis 100%
  • Mutation 50%
  • Fibroblast 50%
  • Myelination 50%
  • Autophagosome 50%
  12 Citations (Scopus)

  9 Downloads (Pure)