Marieke von Lindern

Search results

• 2024

  A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds

  Verheul, T. C. J., Gillemans, N., Putzker, K., Majied, R., Li, T., Vasiliou, M., Eussen, B., de Klein, A., van IJcken, W. F. J., van den Akker, E., von Lindern, M., Lewis, J., Uhrig, U., Nakamura, Y., van Dijk, T. & Philipsen, S., Aug 2024, In: HemaSphere. 8, 8, e139.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Embryonic Hemoglobin 100%
  • Fetal Hemoglobin 100%
  • Hemoglobin F 100%
  • Cell Line 57%
  • Symptom 42%
  3 Downloads (Pure)
• 2022

  Setting the international research agenda for sarcoma together with patients and carers: first results of the Sarcoma Patient EuroNet (SPAEN) priority setting partnership

  Husson, O., Drabbe, C., Schuster, K., van Kampen, P., Koops, C., Weidema, M., Davidson, R., Wartenberg, M., Artzner, E., Gonzato, O., Fernandez, N., Kasper, B., Pilgermann, K., Wilson, R., van der Graaf, W. T. A. & van Oortmerssen, G., Jun 2022, In: ESMO Open. 7, 3, 100509.

  Research output: Contribution to journal › Article › Academic › peer-review

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  • Sarcoma 100%
  • Clinician 16%
  • Patient Advocacy 16%
  • Diseases 8%
  • Neoplasm 8%
  7 Citations (Scopus)

  30 Downloads (Pure)

• Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

  Heshusius, S., Grech, L., Gillemans, N., Brouwer, R. W. W., den Dekker, X. T., van IJcken, W. F. J., Nota, B., Felice, A. E., van Dijk, T. B., von Lindern, M., Borg, J., van den Akker, E. & Philipsen, S., 10 Jan 2022, In: Scientific Reports. 12, 1, 336.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Haploinsufficiency 100%
  • KLF1 100%
  • Epigenomics 100%
  • Embryonic Hemoglobin 75%
  • Gene Expression Profiling 12%
  9 Citations (Scopus)

  26 Downloads (Pure)
• 2016

  The European Hematology Association Roadmap for European Hematology Research: a consensus document

  Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Dohner, H., de Wit, T., Eichinger, S., Fibbe, W., Green, T., de Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Salles, G., Schuringa, J., Andre, M., Andre-Schmutz, I., Bacigalupo, A. & Bochud, P. & 258 others, den Boer, M., Bonini, C., Camaschella, C., Cant, A., Cappellini, M., Cazzola, M., Lo Celso, C., Dimopoulos, M., Douay, L., Dzierzak, E., Einsele, H., Ferreri, A., De Franceschi, L., Gaulard, P., Gottgens, B., Greinacher, A., Gresele, P., Gribben, J., de Haan, G., Hansen, J., Hochhaus, A., Kadir, R., Kaveri, S., Kouskoff, V., Kuhne, T., Kyrle, P., Ljungman, P., Maschmeyer, G., Mendez-Ferrer, S., Milsom, M., Mummery, C., Ossenkoppele, G., Pecci, A., Peyvandi, F., Philipsen, S., Reitsma, P., Ribera, J., Risitano, A., Rivella, S., Ruf, W., Schroeder, T., Scully, M., Socie, G., Staal, F., Stanworth, S., Stauder, R., Stilgenbauer, S., Tamary, H., Theilgaard-Monch, K., Thein, S., Tilly, H., Trneny, M., Vainchenker, W., Vannucchi, A., Viscoli, C., Vrielink, H., Zaaijer, H., Zanella, A., Zolla, L., Zwaginga, J., Martinez, P., van den Akker, E., Allard, S., Anagnou, N., Andrau, J., Angelucci, E., Anstee, D., Aurer, I., Avet-Loiseau, H., Aydinok, Y., Bakchoul, T., Balduini, A., Barcellini, W., Baruch, D., Baruchel, A., Bayry, J., Bento, C., van den Berg, A., Bernardi, R., Bianchi, P., Bigas, A., Biondi, A., Bohonek, M., Bonnet, D., Borchmann, P., Borregaard, N., Braekkan, S., ten Brink, M., Brodin, E., Bullinger, L., Buske, C., Butzeck, B., Cammenga, J., Campo, E., Carbone, A., Cervantes, F., Cesaro, S., Charbord, P., Claas, F., Cohen, H., Conard, J., Coppo, P., Corrons, J., da Costa, L., Davi, F., Delwel, R., Dianzani, I., Domanovic, D., Donnelly, P., Drnovsek, T., Dreyling, M., Du, M., Durand, C., Efremov, D., Eleftheriou, A., Elion, J., Emonts, M., Engelhardt, M., Ezine, S., Falkenburg, F., Favier, R., Federico, M., Fenaux, P., Fitzgibbon, J., Flygare, J., Foa, R., Forrester, L., Galacteros, F., Garagiola, I., Gardiner, C., Garraud, O., van Geet, C., Geiger, H., Geissler, J., Germing, U., Ghevaert, C., Girelli, D., Godeau, B., Gokbuget, N., Goldschmidt, H., Goodeve, A., Graf, T., Graziadei, G., Griesshammer, M., Gruel, Y., Guilhot, F., von Gunten, S., Gyssens, I., Halter, J., Harrison, C., Harteveld, C., Hellstrom-Lindberg, E., Hermine, O., Higgs, D., Hillmen, P., Hirsch, H., Hoskin, P., Huls, G., Inati, A., Johnson, P., Kattamis, A., Kiefel, V., Kleanthous, M., Klump, H., Krause, D., Hovinga, J., Lacaud, G., Lacroix-Desmazes, S., Landman-Parker, J., LeGouill, S., Lenz, G., von Lilienfeld-Toal, M., Lindern, M., Lopez-Guillermo, A., Lopriore, E., Lozano, M., Macintyre, E., Makris, M., Martens, J., Mathas, S., Matzdorff, A., Medvinsky, A., Menendez, P., Migliaccio, A., Miharada, K., Mikulska, M., Minard, V., Montalban, C., de Montalembert, M., Montserrat, E., Morange, P., Mountford, J., Muckenthaler, M., Muller-Tidow, C., Mumford, A., Nadel, B., Navarro, J., el Nemer, W., Noizat-Pirenne, F., O'Mahony, B., Oldenburg, J., Olsson, M., Oostendorp, R., Palumbo, A., Passamonti, F., Patient, R., de Latour, R., Pflumio, F., Pierelli, L., Piga, A., Pollard, D., Raaijmakers, M., Radford, J., Rambach, R., Rao, A., Raslova, H., Rebulla, P., Rees, D., Ribrag, V., Rijneveld, A., Rinalducci, S., Robak, T., Roberts, I., Rodrigues, C., Rosendaal, F., Rosenwald, A., Rule, S., Russo, R., Saglio, G., Sanchez, M., Scharf, R., Schlenke, P., Semple, J., Sierra, J., So-Osman, C., Soria, J., Stamatopoulos, K., Stegmayr, B., Stunnenberg, H., Swinkels, D., Barata, J., Taghon, T., Taher, A., Terpos, E., Thachil, J., Tissot, J., Touw, I., Toye, A., Trappe, R., Traverse-Glehen, A., Unal, S., Vaulont, S., Viprakasit, V., Vitolo, U., van Wijk, R., Wojtowicz, A., Zeerleder, S. & Zieger, B., 2016, In: Haematologica. 101, 2, p. 115-208 94 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  61 Citations (Scopus)

  27 Downloads (Pure)
• 2015

  ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation

  Alemdehy, F., Haanstra, J., de Looper, H., Strien, P., Oldenampsen, J., Caljouw, Y., Sanders, M., Hoogenboezem, R., de Ru, A., Janssen, G., Smetsers, S., Bierings, M., van Veelen, P., Lindern, M., Touw, I. & Erkeland, S., 2015, In: Blood. 125, 25, p. 3937-3948 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  42 Citations (Scopus)
• 2014

  Transfusion-independent ?(0)-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism

  Paciaroni, K., Lucarelli, G., Martelli, F., Migliaccio, A., Lindern, M., Borg, J., Gillemans, N., van Dijk, T. & Philipsen, S., 2014, In: American Journal of Blood Research. 4, 1, p. 27-32 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  7 Citations (Scopus)
• 2013

  Hydroxyurea responsiveness in beta-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity

  Pourfarzad, F., Lindern, M., Azarkeivan, A., Hou, J., Kia, S., Esteghamat, F., van Ijcken, W., Philipsen, S., Najmabadi, H. & Grosveld, F., 2013, In: Haematologica. 98, 5, p. 696-704 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  47 Citations (Scopus)

  15 Downloads (Pure)

• Locus-Specific Proteomics by TChP: Targeted Chromatin Purification

  Pourfarzad, F., Aghajanirefah, A., Boer, E., Ten Have, S., van Dijk, T., Kheradmand Kia, S., Stadhouders, R., Thongjuea, S., Soler, E., Gillemans, N., Lindern, M., Demmers, J., Philipsen, S. & Grosveld, F., 2013, In: Cell Reports. 4, 3, p. 589-600 12 p.

  Research output: Contribution to journal › Article › Academic
  27 Citations (Scopus)

• Red cell distribution width as predictor for mortality in critically ill patients

  Meynaar, I., Knook, M., Coolen, S., Le, H., Bos, M., van der Dijs, F., Lindern, M. & Steyerberg, E., 2013, In: Netherlands Journal of Medicine. 71, 9, p. 488-493 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  57 Citations (Scopus)
• 2012

  Loss of Ercc1 results in a time- and dose-dependent reduction of proliferating early hematopoietic progenitors

  Verhagen-Oldenampsen, J. H. E., Haanstra, J. R., Van Strien, P. M. H., Valkhof, M., Touw, I. P. & Von Lindern, M., 3 Jun 2012, In: Anemia. 2012, 783068.

  Research output: Contribution to journal › Article › Academic › peer-review

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  • Hematopoietic Stem Cell 100%
  • Allele 75%
  • Mouse 37%
  • Mouse Model 12%
  • Hematopoiesis 12%
  6 Citations (Scopus)

  3 Downloads (Pure)

• KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in beta-hemoglobinopathy patients

  Borg, J., Phylactides, M., Bartsakoulia, M., Tafrali, C., Lederer, C., Felice, A., Papachatzopoulou, A., Kourakli, A., Stavrou, E., Christou, S., Hou, J., Karkabouna, S., Lappa-Manakou, C., Ozgur, Z., van Ijcken, W., Lindern, M., Grosveld, F., Georgitsi, M., Kleanthous, M. & Philipsen, S. & 1 others, Patrinos, G., 2012, In: Pharmacogenomics. 13, 13, p. 1487-1500 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  39 Citations (Scopus)

• Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia

  Horos, R. & Lindern, M., 2012, In: British Journal of Haematology. 159, 5, p. 514-527 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts

  Horos, R., Ijspeert, H., Pospisilova, D., Sendtner, R., Andrieu-Soler, C., Taskesen, E., Nieradka, A., Cmejla, R., Sendtner, M., Touw, I. & Lindern, M., 2012, In: Blood. 119, 1, p. 262-272 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  143 Citations (Scopus)
• 2011

  The DNA binding factor Hmg20b is a repressor of erythroid differentiation

  Esteghamat, F., van Dijk, T., Braun, H., Dekker, S., Linden, R., Hou, J., Fanis, P., Demmers, J., van Ijcken, W., Ozgur, Z., Horos, R., Pourfarzad, F., Lindern, M. & Philipsen, S., 2011, In: Haematologica. 96, 9, p. 1252-1260 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2010

  Fetal globin expression is regulated by Friend of Prmt1

  van Dijk, T., Gillemans, N., Pourfarzad, F., van Lom, K., Lindern, M., Grosveld, F. & Philipsen, S., 2010, In: Blood. 116, 20, p. 4349-4352 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  37 Citations (Scopus)

• Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

  Borg, J., Papadopoulos, P., Georgitsi, M., Gutierrez Gutierrez, L., Grech, G., Fanis, P., Phylactides, M., Verkerk, A., van der Spek, P., Scerri, C., Cassar, W., Galdies, R., van Ijcken, W., Ozgur, Z., Gillemans, N., Hou, J., Bugeja, M., Grosveld, F., Lindern, M. & Felice, A. & 2 others, Patrinos, G. & Philipsen, S., 2010, In: Nature Genetics. 42, 9, p. 801-U100

  Research output: Contribution to journal › Article › Academic › peer-review

  328 Citations (Scopus)

• The miR-144/451 locus is required for erythroid homeostasis

  Rasmussen, K., Simmini, S., Abreu-Goodger, C., Bartonicek, N., Di Giacomo, M., Bilbao-Cortes, D., Horos, R., Lindern, M., Enright, A. & O'Carroll, D., 2010, In: Journal of Experimental Medicine. 207, 7, p. 1351-1358 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  265 Citations (Scopus)
• 2009

  EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence

  Kheradmand Kia, S., Solaimani Kartalaei, P., Farahbakhshian, E., Pourfarzad, F., Lindern, M. & Verrijzer, P., 2009, In: Epigenetics & Chromatin. 2, p. 16

  Research output: Contribution to journal › Article › Academic › peer-review
• 2008

  DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia

  Glasow, A., Barrett, A., Petrie, K., Gupta, R., Boix-Chornet, M., Zhou, D., Grimwade, D., Gallagher, R., Lindern, M., Waxman, S., Enver, T., Hildebrandt, G. & Zelent, A., 2008, In: Blood. 111, 4, p. 2374-2377 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)

• Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation

  Grech, G., Blazquez-Domingo, M., Kolbus, A., Bakker, W., Mullner, E., Beug, H. & Lindern, M., 2008, In: Blood. 112, 7, p. 2750-2760 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• Tissue-specific splicing factor gene expression signatures

  Grosso, A., Gomes, A., Barbosa-Morais, N., Caldeira, S., Thorne, N., Grech, G., Lindern, M. & Carmo-Fonseca, M., 2008, In: Nucleic Acids Research. 36, 15, p. 4823-4832 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  137 Citations (Scopus)

  52 Downloads (Pure)
• 2007

  Beta-globin active chromatin hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice

  Kooren, J., Palstra, R.-J., Klous, P., Splinter, E., Lindern, M., Grosveld, F. & de Laat, W., 2007, In: Journal of Biological Chemistry. 282, 22, p. 16544-16552 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  67 Citations (Scopus)

• Differential regulation of Foxo3a target genes in erythropoiesis

  Bakker, W., van Dijk, T., Parren-van Amelsvoort, M., Kolbus, A., Yamamoto, K., Steinlein, P., Verhaak, R., Mak, T., Beug, H., Löwenberg, B. & Lindern, M., 2007, In: Molecular and Cellular Biology. 27, 10, p. 3839-3854 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  67 Citations (Scopus)

• Dynamic regulation of Gata factor levels is more important than their identity

  Ferreira, R., Wai, A., Shimizu, R., Gillemans, N., Rottier, R., Lindern, M., Ohneda, K., Grosveld, F., Yamamoto, M. & Philipsen, S., 2007, In: Blood. 109, 12, p. 5481-5490 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  39 Citations (Scopus)
• 2006

  Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice

  van de Ven, H., Andressoo, J., Holcomb, V., Lindern, M., Jong, W., de Zeeuw, C., Suh, Y., Hasty, P., Hoeijmakers, J., van der Horst, B. & Mitchell, J., 2006, In: PLoS Genetics (print). 2, p. 192-192 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  50 Citations (Scopus)

  9 Downloads (Pure)

• Cell-cycle control in erythropoiesis

  Lindern, M., 2006, In: Blood. 108, 3, p. 781-782 2 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)
• 2005

  Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways

  Glasow, A., Prodromou, N., Xu, K., Lindern, M. & Zelent, A., 2005, In: Blood. 105, 1, p. 341-349 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  62 Citations (Scopus)

• The erythroid phenotype of EKLF-null mice: Defects in hemoglobin metabolism and membrane stability

  Drissen, R., Lindern, M., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F. & Philipsen, S., 2005, In: Molecular and Cellular Biology. 25, 12, p. 5205-5214 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  140 Citations (Scopus)

• Translation initiation factor 4E inhibits differentiation of erythroid progenitors

  Blazquez-Domingo, M., Grech, G. & Lindern, M., 2005, In: Molecular and Cellular Biology. 25, 19, p. 8496-8506 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  34 Citations (Scopus)
• 2004

  Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against trail in erythroid progenitors

  Schmidt, U., van den Akker, E., Parren- van Amelsvoort, M., Litos, G., de Bruijn, M., Gutierrez Gutierrez, L., Hendriks, R., Ellmeier, W., Löwenberg, B., Beug, H. & Lindern, M., 2004, In: Journal of Experimental Medicine. 199, p. 785-795 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  45 Citations (Scopus)

• FOXO3a regulates erythroid differentiation and induces BTG1, an activator of arginine methyl transferase 1

  Bakker, W., Blazquez Domingo, M., Kolbus, A., Besooijen, J., Steinlein, P., Beug, H., Coffer, P., Löwenberg, B., Lindern, M. & van Dijk, T., 2004, In: Journal of Cell Biology. 164, p. 175-184 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  144 Citations (Scopus)

• The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity

  van den Akker, E., van Dijk, T., Schmidt, U., Felida, L., Beug, H., Löwenberg, B. & Lindern, M., 2004, In: Biological Chemistry. 385, p. 409-413 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  38 Citations (Scopus)

• Translational control of Putative protooncogene Nm23M2 by cytokines via phosphoinositide-3-kinase signaling

  Joosten, M., Blazquez Domingo, M., Lindeboom, F., Boulmé, F., Beijen, A., Habermann, B., Löwenberg, B., Beug, H., Müllner, E., Delwel, R. & Lindern, M., 2004, In: Journal of Biological Chemistry. 279, 37, p. 38169-38176 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors

  van den Akker, E., van Dijk, T., Parren- van Amelsvoort, M., Grossmann, K., Schaeper, U., Toney-Earley, K., Waltz, S., Löwenberg, B. & Lindern, M., 2004, In: Blood. 103, p. 4457-4466 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)
• 2003

  Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling

  Kolbus, A., Blazquez Domingo, M., Carotta, S., Bakker, W., Luedemann, S., Lindern, M., Steinlein, P. & Beug, H., 2003, In: Blood. 102, p. 3136-3146 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  87 Citations (Scopus)

• Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ cell tumors

  Looijenga, L., Leeuw, H., Oorschot, M., van Gurp, R., Stoop, H., Gillis, A., de Gouveia Brazao, C., Weber, R., Kirkels, W., van Dijk, T., Lindern, M., Valk, P., Lajos, G., Olah, E., Nesland, J., Fossa, S. & Oosterhuis, W., 2003, In: Cancer Research. 63, p. 7674-7678 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  168 Citations (Scopus)

  12 Downloads (Pure)
• 2002

  MLL-ENL cooperates with SCF to transform primary avian multipotent cells

  Schulte, C., Lindern, M., Steinlein, P., Beug, H. & Wiedemann, L., 2002, In: EMBO Journal. 21, 6, p. 4297-4306 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited

  de Krom, M., Corput, M., Lindern, M., Grosveld, F. & Strouboulis, I., 2002, In: Molecular Cell. 9, p. 1319-1326 8 p.

  Research output: Contribution to journal › Article › Academic
  50 Citations (Scopus)
• 2001

  Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis

  Lindern, M., Deiner, E., Dolznig, H., Parren- van Amelsvoort, M., Hayman, M., Mullner, E. & Beug, H., 2001, In: Oncogene. 20, p. 3651-3664 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  90 Citations (Scopus)
• 2000

  Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2

  Valk, P., Verbakel, S., Lindern, M., Löwenberg, B. & Delwel, R., 2000, In: Hematology Journal. 1, p. 254-263 10 p.

  Research output: Contribution to journal › Article › Academic

  12 Citations (Scopus)

• Protein kinase C alpha controls erythropoietin receptor signaling

  Lindern, M., Parren-van Amelsvoort, M., van Dijk, T., Deiner, E., van den Akker, E., van Emst- de Vries, S., Willems, P., Beug, H. & Löwenberg, B., 2000, In: Journal of Biological Chemistry. 275, 44, p. 34719-34727 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  67 Citations (Scopus)

• Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

  van Dijk, T., van den Akker, E., Parren-van Amelsvoort, M., Mano, H., Löwenberg, B. & Lindern, M., 2000, In: Blood. 96, p. 3406-3413 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  88 Citations (Scopus)

  46 Downloads (Pure)
• 1999

  A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor

  Wessely, O., Bauer, A., Quang, C., Deiner, E., Lindern, M., Mellitzer, G., Steinlein, P., Ghysdael, J. & Beug, H., 1999, In: Biological Chemistry. 380, p. 187-202 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  33 Citations (Scopus)

• The glucocorticoid receptor cooperates with the erythropoietin receptor and c-kit to enhance and sustain proliferation of erythroid progenitors in vitro

  Lindern, M., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K., Löwenberg, B. & Beug, H., 1999, In: Blood. 94, 2, p. 550-559 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  218 Citations (Scopus)

  53 Downloads (Pure)

• The use of in vitro expanded erythroid cells in a model system for the isolation of fetal cells from maternal blood

  Jansen, M., Lindern, M., Beug, H., Brandenburg, H., Wildschut, H., Wladimiroff, J. & Veld, P., 1999, In: Prenatal Diagnosis. 19, p. 323-329 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  25 Citations (Scopus)
• 1998

  Erythroid Krüppel-like Factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the ß-globin locus control region.

  Tewari, R., Gillemans, N., Wijgerde, M., Nuez, B., Lindern, M., Grosveld, F. & Philipsen, S., 1998, In: EMBO Journal. 17, 8, p. 2334-2341 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  72 Citations (Scopus)

• Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo

  Ciana, P., Braliou, G., Demay, F., Lindern, M., Barettino, D., Beug, H. & Stunnenberg, H., 1998, In: EMBO Journal. 17, 24, p. 7382-7394 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)

• The transactivation Domain AF-2 but not the DNA-binding domain of the estrogen receptor is required to inhibit differentiation of avian erythroid progenitors

  Lindern, M., Boer, L., Wessely, O., Parker, M. & Beug, H., 1998, In: Molecular Endocrinology. 12, p. 263-277 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  12 Citations (Scopus)
• 1995

  Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements

  Fornerod, M., Boer, J., Van Baal, S., Jaeglé, M., Von Lindern, M., Murti, K. G., Davis, D., Bonten, J., Buijs, A. & Grosveld, G., 4 May 1995, In: Oncogene. 10, 9, p. 1739-1748 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Chromosome Rearrangement 100%
  • Nuclear Membrane 100%
  • Fusion Gene 100%
  • C-Terminus 66%
  • Subcellular Localization 33%
  145 Citations (Scopus)
• 1992

  The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-Specific dek-can mRNA

  Von Lindern, M., Fornerod, M., Van Baal, S., Jaegle, M., De Wit, T., Buijs, A. & Grosveld, G., Apr 1992, In: Molecular and Cellular Biology. 12, 4, p. 1687-1697 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Acute Myeloid Leukemia 100%
  • Leukemia 100%
  • Messenger RNA 100%
  • Myeloid 100%
  • Chromosome 6 50%
  353 Citations (Scopus)