Melissa Rijken

Search results

• 2025

  Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis

  Boertjes, E. L., Massaar, S., Zeilemaker, A., Konijnenburg, J., Rijken, M., Kavelaars, F. G., Grob, T., Versluis, J., Löwenberg, B., Valk, P. J. M. & Sanders, M. A., 25 Mar 2025, In: Blood Advances. 9, 6, p. 1344-1355 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • DNMT3A 100%
  • Myeloid 100%
  • DNA Damage 100%
  • Thymine-DNA Glycosylase 53%
  • Methyl-CpG-Binding Domain 33%
  14 Downloads (Pure)

• Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant NPM1 measurable residual disease in AML

  Vonk, C. M., Grob, T., Rijken, M., Kavelaars, F. G., Konijnenburg, J., Ossenkoppele, G. J., Manz, M. G., Floisand, Y., Löwenberg, B. & Valk, P. J. M., 11 Mar 2025, In: Blood Advances. 9, 5, p. 1069-1077 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Acute Myeloid Leukemia 100%
  • Next Generation Sequencing 100%
  • NPM1 100%
  • Minimal Residual Disease 100%
  • Genomic DNA 100%
  2 Citations (Scopus)

  19 Downloads (Pure)
• 2024

  Risk Stratification in Older Intensively Treated Patients With AML

  Versluis, J., Metzner, M., Wang, A., Gradowska, P., Thomas, A., Jakobsen, N. A., Kennedy, A., Moore, R., Boertjes, E., Vonk, C. M., Kavelaars, F. G., Rijken, M., Gilkes, A., Schwab, C., Beverloo, H. B., Manz, M., Visser, O., Van Elssen, C. H. M. J., de Weerdt, O. & Tick, L. W. & 14 others, Biemond, B. J., Vekemans, M.-C., Freeman, S. D., Harrison, C. J., Cook, J. A., Dennis, M., Knapper, S., Thomas, I., Craddock, C., Ossenkoppele, G. J., Löwenberg, B., Russell, N., Valk, P. J. M. & Vyas, P., 1 Dec 2024, In: Journal of Clinical Oncology. 42, 34, p. 4084-4094 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Risk Stratification 100%
  • Acute Myelogenous Leukemia 100%
  • Cell Transplantation 100%
  • Hematopoietic Cell 100%
  • Myelodysplastic Syndrome 100%
  8 Citations (Web of Science)

  8 Downloads (Pure)

• Prognostic relevance of molecular measurable residual disease detection in AML with mutated CEBPA

  Vonk, C. M., Boertjes, E. L., Kavelaars, F. G., Rijken, M., Konijnenburg, J. M. L., Cromwell, R. E., Löwenberg, B., Grob, T. & Valk, P. J. M., Aug 2024, In: HemaSphere. 8, 8, e141.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

  Open Access

  File
  17 Downloads (Pure)
• 2023

  High-throughput Proteomics Identifies THEMIS2 as Independent Biomarker of Treatment-free Survival in Untreated CLL

  Hengeveld, P. J., Kolijn, P. M., Demmers, J. A. A., Doff, W., Dubois, J. M. N., Rijken, M., Assmann, J. L. J. C., Van Der Straten, L., Boiten, H. J., Gussinklo, K. J., Valk, P. J. M., Faber, L. M., Westerweel, P. E., Kater, A. P., Levin, M. D. & Langerak, A. W., Oct 2023, In: HemaSphere. 7, 10, E951.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Heavy Chain 100%
  • Proteome 100%
  • Mass Spectrometry 100%
  • Intravenous Immunoglobulin 100%
  • Proteomics 100%
  3 Citations (Scopus)

  58 Downloads (Pure)

• Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia

  Grob, T., Sanders, M. A., Vonk, C. M., Kavelaars, F. G., Rijken, M., Hanekamp, D. W., Gradowska, P. L., Cloos, J., Fløisand, Y., van Marwijk Kooy, M., Manz, M. G., Ossenkoppele, G. J., Tick, L. W., Havelange, V., Löwenberg, B., Jongen-Lavrencic, M. & Valk, P. J. M., 1 Feb 2023, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 41, 4, p. 756-765 10 p., JCO2200715.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Acute Myeloid Leukemia 100%
  • Minimal Residual Disease 100%
  • Myeloid 100%
  • Overall Survival 57%
  • Next Generation Sequencing 42%
  77 Citations (Scopus)

  351 Downloads (Pure)
• 2022

  High-Throughput Proteomics Identifies THEMIS2 As Biomarker of Inferior Treatment-Free Survival in Chronic Lymphocytic Leukemia

  Hengeveld, P., Kolijn, P. M., Demmers, J. A. A., Doff, W., Dubois, J. M. N., Rijken, M., Assmann, J., Van der Straten, L., Boiten, H.-J., Gussinklo, K. J., Valk, P. J. M., Westerweel, P. E., Kater, A. P., Langerak, A. W. & Levin, M.-D., 15 Nov 2022, In: Blood. 140, p. 9851-9852 2 p.

  Research output: Contribution to journal › Meeting Abstract › Academic › peer-review

• AML-234 Prognostic Value of FLT3-ITD Residual Disease in Acute Myeloid Leukemia

  Vonk, C., Grob, T., Sanders, M., Kavelaars, F., Rijken, M., Hanekamp, D., Gradowska, P., Cloos, J., Fl⊘isand, Y., Kooy, M. V. M., Manz, M., Ossenkoppele, G., Tick, L., Vekemans, M. C., Löwenberg, B., Jongen-Lavrencic, M. & Valk, P., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S227

  Research output: Contribution to journal › Article › Academic › peer-review

  • Acute Myeloid Leukemia 100%
  • Minimal Residual Disease 100%
  • Myeloid 100%
  • Next Generation Sequencing 66%
  • Overall Survival 55%
  1 Citation (Scopus)

• AML-279 Molecularly-Defined De Novo and Secondary Acute Myeloid Leukemia Are Biologically and Clinically Different Entities

  Boertjes, E., Hinai, A. A., Stoetman, E., Compagne, K. G., Grob, T., Kavelaars, F. G., Rijken, M., Sanders, M., Beverloo, B. H., Löwenberg, B. & Valk, P. J. M., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S232

  Research output: Contribution to journal › Meeting Abstract › Academic › peer-review

  • Acute Myeloid Leukemia 100%
  • Secondary Acute Myeloid Leukemia 100%
  • De Novo Acute Myeloid Leukemia 100%
  • Myeloid 100%
  • Acute Myelogenous Leukemia 45%

• Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome

  Grob, T., Al Hinai, A. S. A., Sanders, M. A., Kavelaars, F. G., Rijken, M., Gradowska, P. L., Biemond, B. J., Breems, D. A., Maertens, J., van Marwijk Kooy, M., Pabst, T., de Weerdt, O., Ossenkoppele, G. J., van de Loosdrecht, A. A., Huls, G. A., Cornelissen, J. J., Beverloo, H. B., Löwenberg, B., Jongen-Lavrencic, M. & Valk, P. J. M., 14 Apr 2022, In: Blood. 139, 15, p. 2347-2354 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Myeloid 100%
  • Overall Survival 20%
  • Next Generation Sequencing 10%
  • Molecular Disease 10%
  • Cytogenetics 10%
  194 Citations (Scopus)

  161 Downloads (Pure)
• 2021

  Azacytidine Treatment for VEXAS Syndrome

  Raaijmakers, M., Hermans, M., Aalbers, A., Rijken, M., Dalm, V. A. S. H., van Daele, P. & Valk, P., Dec 2021, In: HemaSphere. 5, 12, 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  57 Citations (Scopus)

  171 Downloads (Pure)

• DNA vs cDNA FLT3-ITD allelic ratio and length measurements in adult acute myeloid leukemia

  Cucchi, D. G. J., Vonk, C. M., Rijken, M., Kavelaars, F. G., Merle, P. A., Verhoef, E., Venniker-Punt, B., Kwidama, Z. J., Gradowska, P., Löwenberg, B., Janssen, J. J. W. M., Cloos, J. & Valk, P. J. M., 8 Nov 2021, In: Blood advances. 5, 21, p. 4476-4479 4 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  36 Downloads (Pure)

• PPM1D mutations appear in complete remission after exposure to chemotherapy without predicting emerging AML relapse

  Al Hinai, A. S. A., Grob, T., Rijken, M., Kavelaars, F. G., Zeilemaker, A., Erpelinck-Verschueren, C. A. J., Sanders, M. A., Löwenberg, B., Jongen-Lavrencic, M. & Valk, P. J. M., Sept 2021, In: Leukemia. 35, 9, p. 2693-2697 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  5 Citations (Scopus)
• 2020

  Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia

  Al Hinai, A., Grob, T., Kavelaars, F., Rijken, M., Zeilemaker, A., Erpelinck - Verschueren, C., Gussinklo, K., Sanders, M., van Lom, K. & Valk, P., 2020, In: Leukemia. 34, 8, p. 2220-2224 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Scopus)
• 2018

  MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

  Sanders, M., Chew, E., Flensburg, C., Zeilemaker, A., Miller, S., Al Hinai, A., Bajel, A., Luiken, B., Rijken, M., McIennan, T., Hoogenboezem, R., Kavelaars, F., Frohling, S., Blewitt, M., Bindels, E., Alexander, W., Löwenberg, B., Roberts, A., Valk, P. & Majewski, I., 2018, In: Blood. 132, 14, p. 1526-1534 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  95 Citations (Scopus)

• Population Pharmacokinetics of Amoxicillin in Term Neonates Undergoing Moderate Hypothermia

  Bijleveld, Y., Mathot, R., v.d. Lee, J., Groenendaal, F., Dijk, P., van Heijst, A., Simons, S., Dijkman, K., van Straaten, H., Rijken, M., Zonnenberg, I., Cools, F., Zecic, A., Nuytemans, D., van Kaam, A. & de Haan, T., 2018, In: Clinical Pharmacology & Therapeutics. 103, 3, p. 458-467 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)