Nienke Hagedoorn

Search results

• 2023

  European study confirms the combination of fever and petechial rash as an important warning sign for childhood sepsis and meningitis

  Kohlmaier, B., Leitner, M., PERFORM consortium (Personalised Risk assessment in febrile children to optimise Real-life Management across the European Union), Hagedoorn, N. N., Borensztajn, D. M., von Both, U., Carrol, E. D., Emonts, M., van der Flier, M., de Groot, R., Herberg, J., Levin, M., Lim, E., Maconochie, I. K., Martinon-Torres, F., Nijman, R. G., Pokorn, M., Rivero-Calle, I., Tan, C. D., Tsolia, M., & 5 othersVermont, C. L., Zachariasse, J. M., Zavadska, D., Moll, H. A. & Zenz, W., May 2023, In: Acta Paediatrica, International Journal of Paediatrics. 112, 5, p. 1058-1066 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  • Child 100%
  • Exanthem 60%
  • Rash 60%
  • Odds Ratio 50%
  • Confidence Interval 50%
  3 Downloads (Pure)

• Febrile illness in high-risk children: a prospective, international observational study

  van der Velden, F. J. S., de Vries, G., PERFORM Consortium, Martin, A., Lim, E., von Both, U., Kolberg, L., Carrol, E. D., Khanijau, A., Herberg, J. A., De, T., Galassini, R., Kuijpers, T. W., Martinón-Torres, F., Rivero-Calle, I., Vermont, C. L., Hagedoorn, N. N., Pokorn, M., Pollard, A. J., Schlapbach, L. J., & 15 othersTsolia, M., Elefhteriou, I., Yeung, S., Zavadska, D., Fink, C., Voice, M., Zenz, W., Kohlmaier, B., Agyeman, P. K. A., Usuf, E., Secka, F., de Groot, R., Levin, M., van der Flier, M. & Emonts, M., 2023, In: European Journal of Pediatrics.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Child 100%
  • Bacterial Infection 77%
  • Diseases 55%
  • Virus Infection 55%
  • Fever 44%
  5 Downloads (Pure)
• 2022

  Association of monocyte HLA-DR expression over time with secondary infection in critically ill children: a prospective observational study

  Hagedoorn, N. N., Kolukirik, P., Nagtzaam, N. M. A., Nieboer, D., Verbruggen, S., Joosten, K. F., Moll, H., Driessen, G., Dik, W. A. & Vermont, C., Mar 2022, In: European Journal of Pediatrics. 181, 3, p. 1133–1142 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Association 100%
  • Time 75%
  • Immune Response 50%
  • Monocyte 50%
  • Age 50%
  1 Citation (Scopus)

  13 Downloads (Pure)

• Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians

  Dewez, J. E., Pembrey, L., Nijman, R. G., del Torso, S., Grossman, Z., Hadjipanayis, A., Van Esso, D., Lim, E., Emonts, M., Burns, J., Gras-LeGuen, C., Kohlfuerst, D., Dornbusch, H. J., Brengel-Pesce, K., Mallet, F., von Both, U., Tsolia, M., Eleftheriou, I., Zavadska, D., de Groot, R., & 34 othersvan der Flier, M., Moll, H., Hagedoorn, N., Borensztajn, D., Oostenbrink, R., Kuijpers, T., Pokorn, M., Vincek, K., Martinó n-Torres, F., Rivero, I., Agyeman, P., Carrol, E. D., Paulus, S., Cunnington, A., Herberg, J., Levin, M., Mujkić, A., Geitmann, K., Da Dalt, L., Valiulis, A., Lapatto, R., Syridou, G., Altorjai, P., Torpiano, P., Størdal, K., Illy, K., Mazur, A., Spreitzer, M. V., Rios, J., Wyder, C., Romankevych, I., Basmaci, R., Ibanez-Mico, S. & Yeung, S., 20 Dec 2022, In: PLoS ONE. 17, 12 December, e0275336.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Pediatrician 100%
  • Primary Medical Care 80%
  • Infection 80%
  • Odds Ratio 60%
  • Diagnostic Test 60%
  8 Downloads (Pure)

• Characteristics and management of adolescents attending the ED with fever: A prospective multicentre study

  Borensztajn, D., Hagedoorn, N. N., Carrol, E., Von Both, U., Dewez, J. E., Emonts, M., Van Der Flier, M., De Groot, R., Herberg, J., Kohlmaier, B., Levin, M., Lim, E., Maconochie, I., Martinon Torres, F., Nijman, R., Pokorn, M., Rivero-Calle, I., Tsolia, M., Vermont, C., Zavadska, D., & 3 othersZenz, W., Zachariasse, J. & Moll, H. A., 19 Jan 2022, In: BMJ Open. 12, 1, e053451.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Adolescent 100%
  • Child 50%
  • Bacterial Infection 16%
  • Emergency Ward 16%
  • Sepsis 12%
  2 Citations (Scopus)

  4 Downloads (Pure)

• Febrile children with comorbidities at the emergency department — a multicentre observational study

  Borensztajn, D. M., Hagedoorn, N. N., Carrol, E. D., von Both, U., Emonts, M., van der Flier, M., de Groot, R., Herberg, J., Kohlmaier, B., Levin, M., Lim, E., Maconochie, I. K., Martinon-Torres, F., Nijman, R. G., Pokorn, M., Rivero-Calle, I., Tsolia, M., van der Velden, F. J. S., Vermont, C., Zavadska, D., & 3 othersZenz, W., Zachariasse, J. M. & Moll, H. A., Sept 2022, In: European Journal of Pediatrics. 181, 9, p. 3491-3500 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Child 100%
  • Comorbidity 50%
  • Odds Ratio 45%
  • Emergency Ward 16%
  • Pediatric Intensive Care Unit 16%
  2 Citations (Scopus)

  2 Downloads (Pure)

• Hemostasis Proteins in Invasive Meningococcal and Nonmeningococcal Infections: A Prospective Multicenter Study

  Hagedoorn, N. N., Boeddha, N. P., European Union Childhood Life-threatening Infectious Disease (EUCLIDS) Consortium, Kohlfuerst, D. S., Anderson, S., Carrol, E. D., Agapow, P., van der Flier, M., Hazelzet, J., Herberg, J., Kuijpers, T., Levin, M., Martinon-Torres, F., van Rijswijk, A., Schlapbach, L. J., Vermont, C., Zenz, W., Dik, W. A., Driessen, G. & Emonts, M., Dec 2022, In: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 23, 12, p. e543-e554

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Thrombomodulin 100%
  • Protein 80%
  • Blood Stasis 80%
  • Mortality 80%
  • Pathogen 80%
  1 Citation (Scopus)

  7 Downloads (Pure)

• Rapid Viral Testing and Antibiotic Prescription in Febrile Children with Respiratory Symptoms Visiting Emergency Departments in Europe

  PERFORM Consortium, Tan, C. D., Hagedoorn, N. N., Dewez, J. E., Borensztajn, D. M., Von Both, U., Carrol, E. D., Emonts, M., Van Der Flier, M., De Groot, R., Herberg, J., Kohlmaier, B., Levin, M., Lim, E., MacOnochie, I. K., Martinon-Torres, F., Nijman, R. G., Pokorn, M., Rivero-Calle, I., Strle, F., & 7 othersTsolia, M., Vermont, C. L., Yeung, S., Zachariasse, J. M., Zenz, W., Zavadska, D. & Moll, H. A., 1 Jan 2022, In: Pediatric Infectious Disease Journal. 41, 1, p. 39-44 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antibiotics 100%
  • Child 75%
  • Emergency Department 41%
  • Symptom 16%
  • Logistic Regression Analysis 8%
  2 Citations (Scopus)

• Shock Index in the early assessment of febrile children at the emergency department: A prospective multicentre study

  Hagedoorn, N. N., Zachariasse, J. M., Borensztajn, D., Adriaansens, E., Von Both, U., Carrol, E. D., Eleftheriou, I., Emonts, M., Van Der Flier, M., De Groot, R., Herberg, J. A., Kohlmaier, B., Lim, E., MacOnochie, I., Martinón-Torres, F., Nijman, R. G., Pokorn, M., Rivero-Calle, I., Tsolia, M., Zavadska, D., & 4 othersZenz, W., Levin, M., Vermont, C. & Moll, H. A., 20 Jan 2022, In: Archives of Disease in Childhood. 107, 2, p. 116-122 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Child 100%
  • Shock 57%
  • Shock (Circulatory) 57%
  • Bacterial Infection 42%
  • Intensive Care Unit 21%
  3 Citations (Scopus)

  6 Downloads (Pure)
• 2021

  A NICE combination for predicting hospitalisation at the Emergency Department: a European multicentre observational study of febrile children

  Borensztajn, D. M., Hagedoorn, N. N., PERFORM consortium: Personalised Risk assessment in febrile children to optimise Real-life Management across the European Union, Carrol, E. D., von Both, U., Dewez, J. E., Emonts, M., van der Flier, M., de Groot, R., Herberg, J., Kohlmaier, B., Lim, E., Maconochie, I. K., Martinon-Torres, F., Nieboer, D., Nijman, R. G., Oostenbrink, R., Pokorn, M., Calle, I. R., Strle, F., & 7 othersTsolia, M., Vermont, C. L., Yeung, S., Zavadska, D., Zenz, W., Levin, M. & Moll, H. A., Sept 2021, In: The Lancet Regional Health - Europe. 8, 100173.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Child 100%
  • Area under the Curve 33%
  • Hospitalization 25%
  • Prediction 25%
  • Patient Characteristics 25%
  3 Citations (Scopus)

  5 Downloads (Pure)

• Current Ceftriaxone Dose Recommendations are Adequate for Most Critically Ill Children: Results of a Population Pharmacokinetic Modeling and Simulation Study

  Hartman, S. J. F., Upadhyay, P. J., Hagedoorn, N. N., Mathôt, R. A. A., Moll, H. A., van der Flier, M., Schreuder, M. F., Brüggemann, R. J., Knibbe, C. A. & de Wildt, S. N., Oct 2021, In: Clinical Pharmacokinetics. 60, 10, p. 1361-1372 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Ceftriaxone 100%
  • Minimum Inhibitory Concentration 70%
  • Pharmacokinetics 50%
  • Infectious Agent 30%
  • Pharmacokinetic Modeling 20%
  5 Citations (Scopus)

  20 Downloads (Pure)

• Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

  Boeddha, N. P., Driessen, G. J., Hagedoorn, N. N., Kohlfuerst, D. S., Hoggart, C. J., van Rijswijk, A. L., Ekinci, E., Priem, D., Schlapbach, L. J., Herberg, J. A., de Groot, R., Anderson, S. T., Fink, C. G., Carrol, E. D., van der Flier, M., Martinón-Torres, F., Levin, M., Leebeek, F. W., Zenz, W., de Maat, M. P. M., & 3 othersHazelzet, J. A., Emonts, M. & Dik, W. A., Nov 2021, In: Critical Care Explorations. 3, 11, 12 p., p e0569.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Thrombospondin 100%
  • Metalloproteinase 100%
  • Disintegrin 100%
  • Hospital 62%
  • Sepsis 37%
  3 Downloads (Pure)

• Development and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE, a prospective observational study

  Hagedoorn, N. N., Borensztajn, D., Nijman, R. G., Nieboer, D., Herberg, J. A., Balode, A., Von Both, U., Carrol, E., Eleftheriou, I., Emonts, M., Van Der Flier, M., De Groot, R., Kohlmaier, B., Lim, E., MacOnochie, I., Martinón-Torres, F., Pokorn, M., Strle, F., Tsolia, M., Zavadska, D., & 4 othersZenz, W., Levin, M., Vermont, C. & Moll, H. A., 18 Jun 2021, In: Archives of Disease in Childhood. 106, 7, p. 641-647 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Patient 100%
  • Bacterial Infection 70%
  • Child 60%
  • Observational Study 40%
  • Emergency Ward 30%
  5 Citations (Scopus)

  7 Downloads (Pure)

• Impact of a clinical decision rule on antibiotic prescription for children with suspected lower respiratory tract infections presenting to European emergency departments: A simulation study based on routine data

  Hagedoorn, N. N., Wagenaar, J. H. L., Nieboer, D., Bath, D., Von Both, U., Carrol, E. D., Eleftheriou, I., Emonts, M., Van Der Flier, M., De Groot, R., Herberg, J., Kohlmaier, B., Levin, M., Lim, E., MacOnochie, I., Martinon-Torres, F., Nijman, R., Pokorn, M., Rivero Calle, I., Tsolia, M., & 6 othersYeung, S., Zavadska, D., Zenz, W., Vermont, C. L., Oostenbrink, R. & Moll, H. A., 10 Feb 2021, In: Journal of Antimicrobial Chemotherapy. 76, 5, p. 1349-1357 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Antibiotics 100%
  • Lower Respiratory Tract Infection 72%
  • Emergency 45%
  • Symptom 18%
  • Antibiotic Agent 9%
  11 Downloads (Pure)

• Respiratory Tract Infection Management and Antibiotic Prescription in Children: A Unique Study Comparing Three Levels of Healthcare in the Netherlands

  Van Aerde, K. J., De Haan, L., Van Leur, M., Gerrits, G. P., Schers, H., Moll, H. A., Hagedoorn, N. N., Herberg, J. A., Levin, M., Rivero-Calle, I., De Jonge, M. I., De Groot, R. & Van Der Flier, M., Mar 2021, In: Pediatric Infectious Disease Journal. 40, 3, p. E100-E105 003019.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Antibiotics 100%
  • Respiratory Tract Infection 100%
  • Child 100%
  • Diseases 28%
  • Tertiary Care 28%
  2 Citations (Scopus)

• Variation in hospital admission in febrile children evaluated at the Emergency Department (ED) in Europe: PERFORM, a multicentre prospective observational study

  Borensztajn, D., Hagedoorn, N., Calle, IR., Maconochie, IK., von Both, U., Carrol, ED., Dewez, JE., Emonts, M., Flier, M., Groot, R., Herberg, J., Kohlmaier, B., Lim, E., Martinon-Torres, F., Nieboer, D., Nijman, RG., Pokorn, M., Strle, F., Tsolia, M., Vermont, C., & 5 othersYeung, S., Zavadska, D., Zenz, W., Levin, M. & Moll, H., 7 Jan 2021, In: PLoS One (print). 16, 1, e0244810.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Child 100%
  • Emergency Ward 50%
  • Patient 42%
  • Patient Characteristics 28%
  • Disease Severity 21%
  7 Citations (Web of Science)

  7 Downloads (Pure)
• 2020

  Association between hypotension and serious illness in the emergency department: an observational study

  Hagedoorn, N., Zachariasse, J. & Moll, H., 2020, In: Archives of Disease in Childhood. 105, 6, p. 545-551 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  8 Citations (Scopus)

  7 Downloads (Pure)

• Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study

  Hagedoorn, N., Borensztajn, D., Nijman, R., Balode, A., von Both, U., Carrol, ED., Eleftheriou, I., Emonts, M., Flier, M., de Groot, R., Herberg, J., Kohlmaier, B., Lim, E., Maconochie, I., Martinon-Torres, F., Nieboer, D., Pokorn, M., Strle, F., Tsolia, M., Yeung, S., & 5 othersZavadska, D., Zenz, W., Vermont, C., Levin, M. & Moll, H., 2020, In: PLoS Medicine (print). 17, 8, e1003208.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  37 Citations (Scopus)

  10 Downloads (Pure)
• 2019

  A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review

  Hagedoorn, N., Zachariasse, J. & Moll, H., 2019, In: Critical Care. 23, 1, 380.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  6 Citations (Scopus)

  7 Downloads (Pure)

• Diversity in the emergency care for febrile children in Europe: a questionnaire study

  Borensztajn, D., Yeung, S., Hagedoorn, N., Balode, A., von Both, U., Carrol, ED., Dewez, JE., Eleftheriou, I., Emonts, M., Flier, M., Groot, R., Herberg, JA., Kohlmaier, B., Lim, E., Macconochie, I., Martinon-Torres, F., Nijman, RG., Pokorn, M., Strle, F., Tsolia, M., & 5 othersWendelin, G., Zavadska, D., Zenz, W., Levin, M. & Moll, H., 2019, In: BMJ Paediatrics Open. 3, e000456.

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)