dr. Nikki van Leeuwen

Research output

Research output per year 2012 2021 2021

• 471 Citations
• 24 Article
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2021

  A cause-specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study

  Bugter, O., van Iwaarden, D. L. P., van Leeuwen, N., Nieboer, D., Dronkers, E. A. C., Hardillo, J. A. U. & Baatenburg de Jong, R. J., Jun 2021, In: Head and Neck. 43, 6, p. 1881-1889 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Head and Neck Neoplasms 100%
  • Proportional Hazards Models 88%
  • Neoplasms 32%
  • Neck 25%
  • Head 24%
  2 Citations (Scopus)

  1 Downloads (Pure)

• Assessment of mortality and performance status in critically ill cancer patients: A retrospective cohort study

  van der Zee, E. N., Noordhuis, L. M., Epker, J. L., van Leeuwen, N., Wijnhoven, B. P. L., Benoit, D. D., Bakker, J. & Kompanje, E. J. O., Jun 2021, In: PLoS ONE. 16, 6 June 2021, e0252771.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Critical Illness 100%
  • Cohort Studies 73%
  • Retrospective Studies 72%
  • Intensive Care Units 54%
  • Mortality 54%
  2 Citations (Scopus)

  9 Downloads (Pure)

• Changes in hospital variation in the probability of receiving treatment with curative intent for esophageal and gastric cancer

  Luijten, JCHBM., Vissers, PA., Lingsma, H., van Leeuwen, N., Rozema, T., Siersema, PD., Rosman, C., van Laarhoven, HW., Lemmens, V., Nieuwenhuijzen, GA. & Verhoeven, RH., 2021, In: Cancer Epidemiology. 71, 101897.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Esophageal Neoplasms 100%
  • Stomach Neoplasms 84%
  • Survival 23%
  • Odds Ratio 17%
  • Therapeutics 15%
  2 Citations (Scopus)

  2 Downloads (Pure)

• Cost-effectiveness of prophylactic hysterectomy in first-degree female relatives with Lynch syndrome of patients diagnosed with colorectal cancer in the United States: a microsimulation study

  Alblas, M., Peterse, E. F. P., Du, M., Zauber, A. G., Steyerberg, E. W., van Leeuwen, N. & Lansdorp-Vogelaar, I., Oct 2021, In: Cancer Medicine. 10, 19, p. 6835-6844 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Hysterectomy 75%
  • Cost-Benefit Analysis 65%
  • Colorectal Neoplasms 60%
  • Endometrial Neoplasms 39%
  1 Downloads (Pure)

• Facilitators and barriers for implementing patient-reported outcome measures in clinical care: An academic center's initial experience

  Amini, M., Oemrawsingh, A., Verweij, L. M., Lingsma, H. F., Hazelzet, J. A., Eijkenaar, F. & van Leeuwen, N., Sep 2021, In: Health Policy. 125, 9, p. 1247-1255 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • clinical care 100%
  • language barrier 95%
  • Healthcare Providers 92%
  • Patient Reported Outcome Measures 86%
  • Healthcare 60%
  1 Citation (Scopus)

  3 Downloads (Pure)

• Ordinal outcome analysis improves the detection of between-hospital differences in outcome

  Ceyisakar, I., van Leeuwen, N., Dippel, D., Steyerberg, E. & Lingsma, H., 2021, In: BMC Medical Research Methodology. 21, 1, 4.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Quality of Health Care 100%
  • Traumatic Brain Injury 75%
  • Stroke 52%
  • Glasgow Outcome Scale 51%
  • Health Care Outcome Assessment 50%
  1 Citation (Scopus)

  1 Downloads (Pure)

• Performance feedback on the quality of care in hospitals performing thrombectomy for ischemic stroke (PERFEQTOS): protocol of a stepped wedge cluster randomized trial

  Amini, M., den Hartog, S. J., on behalf of the PERFEQTOS Investigators, van Leeuwen, N., Eijkenaar, F., Kuhrij, L. S., Stolze, L. J., Nederkoorn, P. J., Lingsma, H. F., van Es, A. C. G. M., van den Wijngaard, I. R., van der Lugt, A., Dippel, D. W. J. & Roozenbeek, B., 4 Dec 2021, In: Trials. 22, 1, 870.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Thrombectomy 100%
  • Quality of Health Care 72%
  • Stroke 57%
  • Netherlands 20%
  • Stakeholder Participation 15%
  1 Downloads (Pure)

• Predicting survival in head and neck cancer: External validation and update of the prognostic model OncologIQ in 2189 patients

  Hoesseini, A., van Leeuwen, N., Offerman, M. P. J., Zhang, J., Dronkers, E. A. C., Sewnaik, A., Lingsma, H. F. & Baatenburg de Jong, R. J., 7 May 2021, In: Head and Neck. 43, 8, p. 2445-2456 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Head and Neck Neoplasms 100%
  • Statistics 57%
  • Squamous Cell Carcinoma of Head and Neck 55%
  • Survival 55%
  • Optimism 30%
  3 Citations (Scopus)

• Rasch Analysis of Patient- and Parent-Reported Outcome Measures in the International Consortium for Health Outcomes Measurement Standard Set for Cleft Lip and Palate

  Apon, I., van Leeuwen, N., Allori, AC., Rogers-Vizena, CR., Koudstaal, M., Wolvius, E., Cano, SJ., Klassen, AF. & Versnel, S., Mar 2021, In: Value in Health. 24, 3, p. 404-412 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Cleft Lip 100%
  • Patient Reported Outcome Measures 95%
  • Cleft Palate 95%
  • Oral Health 90%
  • Global Health 85%
  1 Citation (Scopus)
• 2020

  Improving quality of stroke care through benchmarking center performance: why focusing on outcomes is not enough

  Amini, M., van Leeuwen, N., Eijkenaar, F., Mulder, M., Schonewille, W., Nijeholt, GLA., Hinsenveld, WH., Goldhoorn, RJB., van Doormaal, P. J., Jenniskens, S., Hazelzet, J., Dippel, D., Roozenbeek, B. & Lingsma, H., 2020, In: Bmc Health Services Research. 20, 1, 998.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  3 Citations (Scopus)

  1 Downloads (Pure)
• 2019

  Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury

  Huijben, J., Wiegers, E., de Keizer, NF., Maas, AIR., Menon, D., Ercole, A., Cnossen, MC., Polinder, S., Steyerberg, E., van der Jagt, M., Lingsma, H., Grauwmeijer, E., Haitsma, I., Ribbers, G., van Leeuwen, N., Verhofstad, M. & Vos, PE., 2019, In: Critical Care. 23, 95.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  8 Citations (Scopus)

  1 Downloads (Pure)

• Efficient design and analysis of randomized controlled trials in rare neurological diseases: An example in Guillain-Barre syndrome

  van Leeuwen, N., Walgaard, C., van Doorn, P., Jacobs, B. C., Steyerberg, E. & Lingsma, H., 2019, In: PLoS One (online). 14, 2, e0211404.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  2 Citations (Scopus)

  1 Downloads (Pure)

• Value-based healthcare in ischemic stroke care: case-mix adjustment models for clinical and patient-reported outcomes

  Oemrawsingh, A., van Leeuwen, N., Venema, E., Limburg, M., de Leeuw, FE., Wijffels, MP., Groot, AJ., Hilkens, PHE., Hazelzet, J., Dippel, D., Bakker, CH., Voogdt-Pruis, HR. & Lingsma, H., 2019, In: BMC Medical Research Methodology. 19, 1, 229.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  5 Citations (Scopus)

  1 Downloads (Pure)
• 2018

  Patient reported outcome measures in breast cancer patients

  Lagendijk, M., Egdom, P., Richel, C., van Leeuwen, N., Verhoef, K., Lingsma, H. & Koppert, L., 2018, In: European Journal of Surgical Oncology. 44, 7, p. 963-968 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  46 Citations (Scopus)

• Patient-Reported Outcome Measures May Add Value in Breast Cancer Surgery

  Lagendijk, M., Egdom, P., Veen, F., Vos, E., Mureau, M., van Leeuwen, N., Hazelzet, J., Lingsma, H. & Koppert, L., 2018, In: Annals of Surgical Oncology. 25, 12, p. 3563-3571 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  37 Citations (Scopus)

  1 Downloads (Pure)

• Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

  Turcot, V., Lu, YC., Highland, H. M., Schurmann, C., Justice, AE., Fine, RS., Bradfield, JP., Esko, T., Giri, A., Graff, M., Guo, XQ., Hendricks, AE., Karaderi, T., Lempradl, A., Locke, AE., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, KL., Alfred, T. & 380 others, Feitosa, MF., Masca, NGD., Manning, AK., Medina Gomez, M., Mudgal, P., Ng, MCY., Reiner, AP., Vedantam, S., Willems, SM., Winkler, TW., Abecasis, G., Aben, KK., Alam, DS., Alharthi, SE., Allison, M., Amouyel, P., Asselbergs, FW., Auer, PL., Balkau, B., Bang, LE., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, LF., Bluher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Boger, CA., Bork-Jensen, J., Bots, ML., Bottinger, EP., Bowden, DW., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, AA., Butterworth, AS., Campbell, PT., Cappellani, S., Carey, DJ., Catamo, E., Caulfield, MJ., Chambers, JC., Chasman, DI., Chen, YDI., Chowdhury, R., Christensen, C., Chu, AY., Cocca, M., Collins, FS., Cook, J. P., Corley, J., Galbany, JC., Cox, A. J., Crosslin, DS., Cuellar-Partida, G., d'Eustacchio, A., Danesh, J., Davies, G., de Bakker, PIW., de Groot, MCH., de Mutsert, R., Deary, IJ., Dedoussis, G., Demerath, EW., Heijer, M., Hollander, AI., den Ruijter, HM., Dennis, JG., Denny, JC., Di Angelantonio, E., Drenos, F., Du, MM., Dube, MP., Dunning, AM., Easton, DF., Edwards, TL., Ellinghaus, D., Ellinor, PT., Elliott, P., Evangelou, E., Farmaki, AE., Farooqi, IS., Faul, JD., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, JC., Ford, I., Fornage, M., Franco Duran, OH., Franke, A., Franks, PW., Friedrich, N., Frikke-Schmidt, R., Galesloot, TE., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, AP., Gordon-Larsen, P., Gorski, M., Grabe, HJ., Grant, SFA., Grarup, N., Griffiths, HL., Grove, ML., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, AR., Hansen, T., Harris, KM., Harris, TB., Hattersley, AT., Have, CT., Hayward, C., He, L., Heard-Costa, NL., Heath, AC., Heid, IM., Helgeland, O., Hernesniemi, J., Hewitt, AW., Holmen, OL., Hovingh, GK., Howson, JMM., Hu, Y., Huang, PL., Huffman, JE., Ikram, A., Ingelsson, E., Jackson, AU., Jansson, JH., Jarvik, GP., Jensen, GB., Jia, Y., Johansson, S., Jorgensen, ME., Jorgensen, T., Jukema, JW., Kahali, B., Kahn, RS., Kahonen, M., Kamstrup, PR., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, SLR., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, LA., Kim, E., Kitajima, H., Komulainen, P., Kooner, JS., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, TA., Lamparter, D., Lange, E., Lange, LA., Langenberg, C., Larson, EB., Lee, NR., Lehtimaki, T., Lewis, CE., Li, HX., Li, J., Li-Gao, RF., Lin, HH., Lin, KH., Lin, LA., Lin, X., Lind, L., Lindstrom, J., Linneberg, A., Liu, CT., Liu, D. J. J., Liu, YM., Lo, KS., Lophatananon, A., Lotery, AJ., Loukola, A., Luan, J., Lubitz, SA., Lyytikainen, LP., Mannisto, S., Marenne, G., Mazul, AL., McCarthy, MI., McKean-Cowdin, R., Medland, SE., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, KL., Moilanen, L., Moitry, M., Montgomery, GW., Mook, D., Moore, C., Mori, TA., Morris, AD., Morris, AP., Muller-Nurasyid, M., Munroe, PB., Nalls, MA., Narisu, N., Nelson, CP., Neville, M., Nielsen, SF., Nikus, K., Njolstad, PR., Nordestgaard, BG., Nyholt, DR., O'Connel, JR., O'Donoghue, ML., Loohuis, LMO., Ophoff, RA., Owen, KR., Packard, CJ., Padmanabhan, S., Palmer, CNA., Palmer, ND., Pasterkamp, G., Patel, AP., Pattie, A., Pedersen, O., Peissig, PL., Peloso, GM., Pennell, CE., Perola, M., Perry, JA., Perry, JRB., Pers, TH., Person, TN., Peters, A., Petersen, E. R. B., Peyser, PA., Pirie, A., Polasek, O., Polderman, TJ., Puolijoki, H., Raitakari, OT., Rasheed, A., Rauramaa, R., Reilly, D. F., Renstrom, F., Rheinberger, M., Ridker, PM., Rioux, JD., Rivas, MA., Roberts, DJ., Robertson, NR., Robino, A., Rolandsson, O., Rudan, I., Ruth, KS., Saleheen, D., Salomaa, V., Samani, NJ., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, PJ., Schulze, MB., Scott, RA., Segura-Lepe, M. P., Shah, SH., Sheu, WHH., Sim, XL., Slater, A. J., Small, KS., Smith, AV., Southam, L., Spector, TD., Speliotes, EK., Starr, JM., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, HM., Stumvoll, M., Sun, L., Surendran, P., Swift, AJ., Tada, H., Tansey, KE., Tardif, JC., Taylor, KD., Teumer, A., Thompson, DJ., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tonjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, JP., Uher, R., Uitterlinden, A., Uusitupa, M., Laan, SW., Duijn, C., van Leeuwen, N., van Setten, J., Vanhala, M., Varbo, A., Varga, TV., Varma, R., Edwards, D. R. V., Vermeulen, SH., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, TF., Volker, U., Vuckovic, D., Wagenknecht, LE., Walker, M., Wallentin, L., Wang, FJ., Wang, CA., Wang, S., Wang, YQ., Ware, EB., Wareham, NJ., Warren, HR., Waterworth, DM., Wessel, J., White, HD., Willer, CJ., Wilson, JG., Witte, DR., Wood, AR., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, LM., Young, R., Zeggini, E., Zhan, XW., Zhang, WH., Zhao, JH., Zhao, W., Zhou, W., Zondervan, KT., Rotter, JI., Pospisilik, JA., Rivadeneira, F., Borecki, IB., Deloukas, P., Frayling, TM., Lettre, G., North, KE., Lindgren, CM., Hirschhorn, JN. & Loos, RJF., 2018, In: Nature Genetics. 50, 1, p. 26-+

  Research output: Contribution to journal › Article › Academic › peer-review
  168 Citations (Scopus)

• Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials

  van Leeuwen, N., Lingsma, H., Mooijaart, SP., Nieboer, D., Trompet, S. & Steyerberg, E., 2018, In: Journal of Clinical Epidemiology. 98, p. 70-79 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)
• 2017

  Validated age-specific reference values for CSF total protein levels in children

  Kahlmann, V., Roodbol, J., van Leeuwen, N., Ramakers, C., van Pelt - T Gravesteijn, E., Neuteboom, R., Catsman - Berrevoets, C., de Wit, M. C. & Jacobs, B. C., 2017, In: European Journal of Paediatric Neurology. 21, 4, p. 654-660 7 p.

  Research output: Contribution to journal › Article › Academic
  12 Citations (Scopus)
• 2016

  Hospital Admissions, Transfers and Costs of Guillain-Barre Syndrome

  van Leeuwen, N., Lingsma, H., Vanrolleghem, A., Sturkenboom, MCJM., van Doorn, P., Steyerberg, E. & Jacobs, B. C., 2016, In: PLoS One (print). 11, 2

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  7 Citations (Scopus)

  1 Downloads (Pure)

• Regression Discontinuity Design Simulation and Application in Two Cardiovascular Trials with Continuous Outcomes

  van Leeuwen, N., Lingsma, H., de Craen, AJM., Nieboer, D., Mooijaart, SP., Richard, E. & Steyerberg, E., 2016, In: Epidemiology. 27, 4, p. 503-511 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)
• 2014

  Health-related quality of life in Guillain- Barr ' e syndrome patients: a systematic review

  Darweesh, S., Polinder, S., Mulder, M., Pellegrino Baena, C., van Leeuwen, N., Franco Duran, OH., Jacobs, B. C. & van Doorn, P., 2014, In: Journal of the Peripheral Nervous System. 19, 1, p. 24-35 12 p.

  Research output: Contribution to journal › Article › Academic
  23 Citations (Scopus)
• 2013

  A 3-Plex Methylation Assay Combined with the FGFR3 Mutation Assay Sensitively Detects Recurrent Bladder Cancer in Voided Urine

  Kandimalla, R., Masius, R., Beukers, W., Bangma VERVALLEN, CH., Orntoft, TF., Dyrskjot, L., van Leeuwen, N., Lingsma, H., van Tilborg, AAG. & Zwarthoff, E., 2013, In: Clinical Cancer Research. 19, 17, p. 4760-4769 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  45 Citations (Scopus)

• Tools & Techniques: Analysis of clustered data in interventional cardiology: current practice and methodological advice

  Lingsma, H., Nauta, S., van Leeuwen, N., Borsboom, G., Bruining, N. & Steyerberg, E., 2013, In: EuroIntervention. 9, 1, p. 162-164 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2012

  Prognostic Value of Major Extracranial Injury in Traumatic Brain Injury: An Individual Patient Data Meta-analysis in 39 274 Patients

  van Leeuwen, N., Lingsma, H., Perel, P., Lecky, F., Roozenbeek, B., Lu, J., Shakur, H., Weir, J., Steyerberg, E. & Maas, AIR., 2012, In: Neurosurgery. 70, 4, p. 811-818 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  71 Citations (Scopus)