Peter van Koetsveld

2024

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature

Mulders, M. C. F., Audhoe, A. S., Van Koetsveld, P. M., Feelders, R. A., Hofland, L. J., de Herder, W. W., Kraaij, R. & Hofland, J., Jan 2024, In: European Journal of Cancer. 197, 113472.

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3 Citations (Scopus)

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2023

Applying HDACis to increase SSTR2 expression and radiolabeled DOTA-TATE uptake: from cells to mice

Klomp, M. J., van den Brink, L., van Koetsveld, P. M., de Ridder, C. M. A., Stuurman, D. C., Löwik, C. W. G. M., Hofland, L. J. & Dalm, S. U., 1 Dec 2023, In: Life Sciences. 334, 122173.

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EANM'23 Abstract Book Congress Sep 9-13, 2023: What is the Effect on Radiolabeled DOTATATE uptake?

Klomp, M. J., van den Brink, L., van Koetsveld, P. M., de Ridder, C. M. A., Stuurman, D. C., Hofland, L. J. & Dalm, S. U., 1 Sept 2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 50, SUPPL 1, p. 1-898 898 p.

Research output: Contribution to journal › Meeting Abstract › Academic › peer-review

7 Citations (Scopus)

The Role of the IGF2 Methylation Score in Diagnosing Adrenocortical Tumors with Unclear Malignant Potential—Feasibility of Formalin-Fixed Paraffin-Embedded Tissue

Steenaard, R. V., Feelders, R. A., Dogan, F., van Koetsveld, P. M., Creemers, S. G., Ettaieb, M. H. T., van Kemenade, F. J., Haak, H. R. & Hofland, L. J., 17 Jul 2023, In: Biomedicines. 11, 7, 2013.

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1 Citation (Scopus)

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Epigenetic regulation of SST₂ expression in small intestinal neuroendocrine tumors

Klomp, M. J., Refardt, J., van Koetsveld, P. M., Campana, C., Dalm, S. U., Dogan, F., van Velthuysen, M. L. F., Feelders, R. A., de Herder, W. W., Hofland, J. & Hofland, L. J., 8 May 2023, In: Frontiers in Endocrinology. 14, 1184436.

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2 Citations (Scopus)

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Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in GH- and GH/PRL-Secreting Pituitary Tumors

Gatto, F., Feelders, R. A., van Koetsveld, P. M., Dogan, F., Neggers, S. J. C. C. M. M., van der Lelij, A.-J., Amarù, J., Ferone, D. & Hofland, L. J., 1 May 2023, In: The Journal of clinical endocrinology and metabolism. 108, 5, p. E98-E109 dgac675.

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4 Citations (Scopus)

2022

Modulating the Epigenetic Machinery for Increased SSTR2 Expression in Small-Cell Lung Cancer Cells

Klomp, M. J., Hofland, L. J., van den Brink, L., van Koetsveld, P. M., de Jong, M. & Dalm, S. U., Sept 2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, Suppl 1, p. S57-S57 1 p., OP-166.

Research output: Contribution to journal › Meeting Abstract › Academic › peer-review

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Immunomodulatory antitumor effect of interferon‑beta combined with gemcitabine in pancreatic cancer

Blaauboer, A., Van Koetsveld, P. M., Mustafa, D. A. M., Dumas, J., Dogan, F., Van Zwienen, S., Van Eijck, C. H. J. & Hofland, L. J., Aug 2022, In: International Journal of Oncology. 61, 2, 97.

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2 Citations (Scopus)

Digital quantification of somatostatin receptor subtype 2a immunostaining: a validation study

Campana, C., van Koetsveld, P. M., Feelders, R. A., de Herder, W. W., Iyer, A. M., van Velthuysen, M. L. F., Veenstra, M. J., van den Dungen, E. S. R., Franck, S. E., Ferone, D., Gatto, F. & Hofland, L. J., 21 Jul 2022, In: European Journal of Endocrinology. 187, 3, p. 399-411 13 p.

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5 Citations (Scopus)

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Reciprocal Interactions between Fibroblast and Pancreatic Neuroendocrine Tumor Cells: Putative Impact of the Tumor Microenvironment

Cuny, T., van Koetsveld, P. M., Mondielli, G., Dogan, F., de Herder, W. W., Barlier, A. & Hofland, L. J., 18 Jul 2022, In: Cancers. 14, 14, 3481.

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6 Citations (Scopus)

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Effect of epigenetic treatment on SST2 expression in neuroendocrine tumour patients

Refardt, J., Klomp, M. J., van Koetsveld, P. M., Dogan, F., Konijnenberg, M., Brabander, T., Feelders, R. A., de Herder, W. W., Hofland, L. J. & Hofland, J., Jul 2022, In: Clinical and Translational Medicine. 12, 7, e957.

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Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor–Interacting Protein–mutated Pediatric Somatotropinoma

van Santen, S. S., Daly, A. F., Buchfelder, M., Coras, R., Zhao, Y., Beckers, A., van der Lely, A. J., Hofland, L. J., Balvers, R. K., van Koetsveld, P., van den Heuvel-Eibrink, M. M. & Neggers, S. J. C. M. M., 1 May 2022, In: AACE Clinical Case Reports. 8, 3, p. 119-123 5 p.

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2 Citations (Scopus)

39 Downloads (Pure)

The Class I HDAC Inhibitor Valproic Acid Strongly Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Immune System Activation

Blaauboer, A., van Koetsveld, P. M., Mustafa, D. A. M., Dumas, J., Dogan, F., van Zwienen, S., van Eijck, C. H. J. & Hofland, L. J., 22 Feb 2022, In: Biomedicines. 10, 3, 517.

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8 Citations (Scopus)

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The Effect of VPA Treatment on Radiolabeled DOTATATE Uptake: Differences Observed In Vitro and In Vivo

Klomp, M. J., Hofland, L. J., van den Brink, L., van Koetsveld, P. M., Dogan, F., de Ridder, C. M. A., Stuurman, D. C., Clahsen-Van Groningen, M. C., de Jong, M. & Dalm, S. U., 12 Jan 2022, In: Pharmaceutics. 14, 1, 173.

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4 Citations (Scopus)

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2021

Comparing the effect of multiple histone deacetylase inhibitors on sstr2 expression and [¹¹¹in]in‐dotatate uptake in net cells

Klomp, M. J., Dalm, S. U., van Koetsveld, P. M., Dogan, F., de Jong, M. & Hofland, L. J., 1 Oct 2021, In: Cancers. 13, 19, 4905.

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9 Citations (Scopus)

131 Downloads (Pure)

Extensive in vitro and in vivo evaluation of SSTR2-mediated uptake and biodistribution of radiolabeled somatostatin analogues after treatment with HDAC inhibitor valproic acid

Klomp, M., Hofland, L. J., Van den Brink, L. & Van Koetsveld, P. M., Sept 2021, In: European Journal of Nuclear Medicine and Molecular Imaging. 48, SUPPL 1, p. S421-S421 1 p., EPS-071.

Research output: Contribution to journal › Meeting Abstract › Academic › peer-review

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Modifying Effects of Glucose and Insulin/Insulin-Like Growth Factors on Colon Cancer Cells

Berk, Ş., Janssen, J. A. M. J. L., van Koetsveld, P. M., Dogan, F., Değerli, N., Özcan, S., Kelestimur, F. & Hofland, L. J., 5 Jul 2021, In: Frontiers in Oncology. 11, 645732.

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4 Citations (Scopus)

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Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment

Creemers, S. G., Feelders, R. A., De Jong, F. H., Franssen, G. J. H., De Rijke, Y. B., Van Koetsveld, P. M. & Hofland, L. J., 1 Apr 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 4, p. E1618-E1630

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20 Citations (Scopus)

103 Downloads (Pure)

2020

Increased SST 2 Expression on Pulmonary Neuroendocrine Tumor Cells by Epigenetic Drug Treatment with Histone Deacetylase Inhibitors

Klomp, I., Dalm, S. U., van Koetsveld, P. M., Dogan-Oruc, F., de Jong, M. & Hofland, L. J., Sept 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, Suppl 1, p. S411-S412 2 p., OP-830.

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6 Citations (Scopus)

DNA Methyltransferase Inhibitor Hydralazine Induces Upregulation of Somatostatin Type 2 Receptors in Human Neuroendocrine Tumor Cells

Refardt, J., Klomp, I., van Koetsveld, P. M., Dogan-Oruc, F., de Herder, W. W., Hofland, J. & Hofland, L. J., Mar 2020, In: Neuroendocrinology. 110, p. 46-46 1 p., C13.

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1 Citation (Web of Science)

Epigenetic Treatment with Histone Deacetylase Inhibitor Enhances Uptake of [¹¹¹In]In-DOTA-TATE by Increased SST2 Expression on Neuroendocrine Tumor Cells

Klomp, I., Daim, S. U., van Koetsveld, P. M., Dogan-Oruc, F., de Jong, M. & Hofland, L. J., Mar 2020, In: Neuroendocrinology. 110, p. 44-44 1 p., C11.

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1 Citation (Scopus)

Effect of the Tryptophan Hydroxylase Inhibitor Telotristat on Growth and Serotonin Secretion in 2D and 3D Cultured Pancreatic Neuroendocrine Tumor Cells

Herrera Martinez, A., Feelders, R. A., van den Dungen, R., Dogan - Oruç, F., van Koetsveld, P., Castano, J., de Herder, W. W. & Hofland, L., 2020, In: Neuroendocrinology. 110, 5, p. 351-363 13 p.

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13 Citations (Scopus)

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Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer

Blaauboer, A., Booij, S., van Koetsveld, P., Karels, B., Dogan - Oruç, F., Zwienen, S., van Eijck, C. & Hofland, L., 2020, In: BMC Cancer. 20, 1, 913.

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12 Citations (Scopus)

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The Efficacy of Mitotane in Human Primary Adrenocortical Carcinoma Cultures

van Koetsveld, P., Creemers, S., Dogan - Oruç, F., Franssen, G., de Herder, W. W., Feelders, R. A. & Hofland, L., 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 2, p. 407-417 11 p.

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13 Citations (Scopus)

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β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids

Gatto, F., Feelders, R. A., Pas, R., van Koetsveld, P., Bruzzone, E., Arvigo, M., Dogan - Oruç, F., Lamberts, S. W. J., Ferone, D. & Hofland, L., 2020, In: Journal of Endocrinology. 245, 1, p. 101-113 13 p.

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3 Citations (Scopus)

2019

Epigenetic Treatment with Histone Deacetylase Inhibitor Increases Uptake of [<SUP>111</SUP>In]In-DOTA-TATE by Neuroendocrine Tumor Cells

Klomp, I., Dalm, S. U., van Koetsveld, P. M., Dogan-Oruc, F., de Jong, M. & Hofland, L. J., Oct 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46, SUPPL 1, p. S693-S694 2 p., EP-0677.

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Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumor Cells

Herrera Martinez, A., Feelders, R. A., de Herder, W. W., Castano, J., Moreno, M., Dogan - Oruç, F., van den Dungen, R., van Koetsveld, P. & Hofland, L., 2019, In: Hormones and Cancer. 10, 2-3, p. 107-119 13 p.

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13 Citations (Scopus)

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Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors

Herrera Martinez, A., van den Dungen, R., Dogan - Oruç, F., van Koetsveld, P., Culler, M., de Herder, W. W., Luque, R., Feelders, R. A. & Hofland, L., 2019, In: Endocrine-Related Cancer. 26, 6, p. 585-599 15 p.

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21 Citations (Scopus)

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

Martino, C., van Koetsveld, P., Feelders, R. A., de Herder, W. W., Dogan - Oruç, F., Janssen, J., Bruinink, D., Pivonello, C., Waaijers, A., Colao, A., de Krijger, R., Pivonello, R. & Hofland, L., 2019, In: Endocrine. 64, 3, p. 673-684 12 p.

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26 Citations (Scopus)

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MDR1 inhibition increases sensitivity to doxorubicin and etoposide in adrenocortical cancer

Creemers, S., van Koetsveld, P., de Herder, W. W., Dogan - Oruç, F., Franssen, G., Feelders, R. A. & Hofland, L., 2019, In: Endocrine-Related Cancer. 26, 3, p. 367-378 12 p.

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18 Citations (Scopus)

Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study

Creemers, S., Feelders, R. A., Jong, F., Franssen, G., de Rijke, Y., van Koetsveld, P. & Hofland, L., 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 8, p. 3437-3449 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

2018

Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells

Veenstra, M., van Koetsveld, P., Dogan - Oruç, F., Farrell, W., Feelders, R. A., Lamberts, S. W. J., de Herder, W. W., Vitale, G. & Hofland, L., 2018, In: Oncotarget. 9, 19, p. 14791-14802 12 p.

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52 Citations (Scopus)

2017

Identification of Mutations in Cell-Free Circulating Tumor DNA in Adrenocortical Carcinoma: A Case Series

Creemers, S., Korpershoek, E., Atmodimedjo, P., Dinjens, W., van Koetsveld, P., Feelders, R. A. & Hofland, L., 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 10, p. 3611-3615 5 p.

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26 Citations (Scopus)

In Vitro Head-to-Head Comparison Between Octreotide and Pasireotide in GH-Secreting Pituitary Adenomas

Gatto, F., Feelders, R. A., Franck, S., van Koetsveld, P., Dogan - Oruç, F., Kros, J. M., Neggers, S. J. C. M. M., Lelij, A. J., Lamberts, S. W. J., Ferone, D. & Hofland, L., 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 2009-2018 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

2016

Effects of Somatostatin Analogs and Dopamine Agonists on Insulin-Like Growth Factor 2-Induced Insulin Receptor Isoform A Activation by Gastroenteropancreatic Neuroendocrine Tumor Cells

Adrichem, R., de Herder, W. W., Kamp, K., Brugts, M., de Krijger, R., Mooij, D., Lamberts, S. W. J., van Koetsveld, P., Janssen, J. A. M. J. L. & Hofland, L., 1 Sept 2016, In: Neuroendocrinology. 103, 6, p. 815-825 11 p.

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12 Citations (Scopus)

16 Downloads (Pure)

Effects of combination treatment with sirolimus and mitotane on growth of human adrenocortical carcinoma cells

Martino, C., van Koetsveld, P., Feelders, R. A., Lamberts, S. W. J., de Herder, W. W., Colao, A., Pivonello, R. & Hofland, L., 2016, In: Endocrine. 52, 3, p. 664-667 4 p.

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7 Citations (Scopus)

30 Downloads (Pure)

Inhibition of Human Adrenocortical Cancer Cell Growth by Temozolomide in Vitro and the Role of the MGMT Gene

Creemers, S., van Koetsveld, P., van den Dungen, R., Korpershoek, E., van Kemenade, F., Franssen, G., de Herder, W. W., Feelders, R. A. & Hofland, L., 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4574-4584 11 p.

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15 Citations (Scopus)

Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors

Vandamme, T., Beyens, M., De Beeck, K., Dogan - Oruç, F., van Koetsveld, P., Pauwels, P., Mortier, G., Vangestel, C., de Herder, W. W., van Camp, G., Peeters, M. & Hofland, L., 2016, In: British Journal of Cancer. 114, 6, p. 650-658 9 p.

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66 Citations (Scopus)

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Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas

Creemers, S., van Koetsveld, P., van Kemenade, F., Papathomas, T., Franssen, G., Dogan - Oruç, F., Eekhoff, E., van der Valk, P., de Herder, W. W., Janssen, J. A. M. J. L., Feelders, R. A. & Hofland, L., 2016, In: Endocrine-Related Cancer. 23, 9, p. 727-737 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

2015

IFN-beta is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in human pancreatic cancer cells

Booij, S., van Eijck, C., Janssen, J. A. M. J. L., Dogan - Oruç, F., van Koetsveld, P. & Hofland, L., 2015, In: American Journal of Cancer Research. 5, 6, p. 2035-2046 12 p.

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IFN-β is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in human pancreatic cancer cells

Booy, S., van Eijck, C. H. J., Janssen, J. A. M. J. L., Dogan, F., van Koetsveld, P. M. & Hofland, L. J., 2015, In: American Journal of Cancer Research. 5, 6, p. 2035-2046 12 p.

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4 Citations (Scopus)

Type I Interferon Receptor Expression in Human Pancreatic and Periampullary Cancer Tissue

Booij, S., Hofland, L., Waaijers, M., Croze, E., van Koetsveld, P., Vogel, L., Biermann, K. & van Eijck, C., 2015, In: Pancreas. 44, 1, p. 99-105 7 p.

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10 Citations (Scopus)

2014