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Dive into the research topics where Sophie Ottema is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Pastoors, D., Havermans, M., Mulet-Lazaro, R., Smeenk, L., Ottema, S., Erpelinck-Verschueren, C., van Herk, S., Anthonissen, M., Grob, T., Subramanian, S., Thoms, J. A. I., Pimanda, J. E., Wouters, B. J., Beverloo, B., Haferlach, T., Haferlach, C., Zuber, J., Bindels, E. & Delwel, R., 18 Dec 2025, In: Blood. 146, 25, p. 3098-3105 8 p.Research output: Contribution to journal › Article › Academic › peer-review
3 Citations (Scopus) -
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia
Smeenk, L., Ottema, S., Mulet-Lazaro, R., Ebert, A., Havermans, M., Varea, A. A., Fellner, M., Pastoors, D., van Herk, S., Erpelinck-Verschueren, C., Grob, T., Hoogenboezem, R. M., Kavelaars, F. G., Matson, D. R., Bresnick, E. H., Bindels, E. M., Kentsis, A., Zuber, J. & Delwel, R., Nov 2021, In: Cancer Discovery. 11, 11, p. 2868-2883 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access33 Citations (Scopus) -
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Ottema, S., Mulet-Lazaro, R., Erpelinck-Verschueren, C., van Herk, S., Havermans, M., Arricibita Varea, A., Vermeulen, M., Beverloo, H. B., Gröschel, S., Haferlach, T., Haferlach, C., J. Wouters, B., Bindels, E., Smeenk, L. & Delwel, R., 28 Sept 2021, In: Nature Communications. 12, 1, 13 p., 5679.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile50 Citations (Scopus)148 Downloads (Pure) -
Enhancer hijacking by EVI1 in acute myeloid leukemia
Ottema, S., 21 Sept 2021, Rotterdam.Research output: Types of Thesis › Doctoral Thesis › Internal
File145 Downloads (Pure) -
Derepression of retroelements in acute myeloid leukemia with 3q aberrations
Mika, J., Ottema, S., Kiehlmeier, S., Kruse, S., Smeenk, L., Müller, J., Schweiggert, S., Herrmann, C., Sanders, M., Delwel, R. & Gröschel, S., 1 Aug 2021, In: Haematologica. 106, 8, p. 2269-2273 5 p.Research output: Contribution to journal › Article › Professional
Open Access