11q13 is a susceptibility locus for hormone receptor positive breast cancer

D Lambrechts; T Truong; C Justenhoven; MK Humphreys; Johnny Wang; JL Hopper; GS Dite; C Apicella; MC Southey; Marjanka K Schmidt; A Broeks; S Cornelissen; R van Hien; E Sawyer; I Tomlinson; M Kerin; N Miller; RL Milne; MP Zamora; JIA Perez; J Benitez; U Hamann; YD Ko; T Bruning; J Chang-Claude; U Eilber; R Hein; S Nickels; D Flesch-Janys; S Wang-Gohrke; EM John; A Miron; R Winqvist; K Pylkas; A Jukkola-Vuorinen; M Grip; G Chenevix-Trench; J Beesley; XQ Chen; F Menegaux; E Cordina-Duverger; CY Shen; JC Yu; PE Wu; MF Hou; IL Andrulis; T Selander; G Glendon; AM Mulligan; H Anton-Culver; A Ziogas; KR Muir; A Lophatananon; S Rattanamongkongul; P Puttawibul; M Jones; N Orr; A Ashworth; A Swerdlow; G Severi; L Baglietto; G Giles; M Southey; F Marme; A Schneeweiss; C Sohn; B Burwinkel; BT Yesilyurt; P Neven; R Paridaens; H Wildiers; H Brenner; H Muller; V Arndt; C Stegmaier; A Meindl; S Schott; CR Bartram; RK Schmutzler; A Cox; IW Brock; G Elliott; SS Cross; PA Fasching; R Schulz-Wendtland; AB Ekici; MW Beckmann; O Fletcher; N Johnson; ID Silva; J Peto; H Nevanlinna; TA Muranen; K Aittomaki; C Blomqvist; T Dork; P Schurmann; M Bremer; P Hillemanns; NV Bogdanova; NN Antonenkova; YI Rogov; JH Karstens; E Khusnutdinova; M Bermisheva; D Prokofieva; S Gancev; A Jakubowska; J Lubinski; K Jaworska; K Durda; BG Nordestgaard; SE Bojesen; C Lanng; A Mannermaa; V Kataja; VM Kosma; JM Hartikainen; P Radice; P Peterlongo; S Manoukian; L Bernard; FJ Couch; JE Olson; XS Wang; Z Fredericksen; GG Alnaes; V Kristensen; AL Borresen-Dale; P Devilee; RAEM Tollenaar; Caroline Seynaeve; Maartje Hooning; M Garcia-Closas; SJ Chanock; J Lissowska; ME Sherman; P Hall; JJ Liu; K Czene; D Kang; KY Yoo; DY Noh; A Lindblom; S Margolin; AM Dunning; PDP Pharoah; DF Easton; P Guenel; H Brauch

doi:10.1002/humu.22089

11q13 is a susceptibility locus for hormone receptor positive breast cancer

D Lambrechts
, T Truong
, C Justenhoven
, MK Humphreys
, Johnny Wang
, JL Hopper
, GS Dite
, C Apicella
, MC Southey
, Marjanka K Schmidt
, A Broeks
, S Cornelissen
, R van Hien
, E Sawyer
, I Tomlinson
, M Kerin
, N Miller
, RL Milne
, MP Zamora
, JIA Perez

J Benitez, U Hamann, YD Ko, T Bruning, J Chang-Claude, U Eilber, R Hein, S Nickels, D Flesch-Janys, S Wang-Gohrke, EM John, A Miron, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, G Chenevix-Trench, J Beesley, XQ Chen, F Menegaux, E Cordina-Duverger, CY Shen, JC Yu, PE Wu, MF Hou, IL Andrulis, T Selander, G Glendon, AM Mulligan, H Anton-Culver, A Ziogas, KR Muir, A Lophatananon, S Rattanamongkongul, P Puttawibul, M Jones, N Orr, A Ashworth, A Swerdlow, G Severi, L Baglietto, G Giles, M Southey, F Marme, A Schneeweiss, C Sohn, B Burwinkel, BT Yesilyurt, P Neven, R Paridaens, H Wildiers, H Brenner, H Muller, V Arndt, C Stegmaier, A Meindl, S Schott, CR Bartram, RK Schmutzler, A Cox, IW Brock, G Elliott, SS Cross, PA Fasching, R Schulz-Wendtland, AB Ekici, MW Beckmann, O Fletcher, N Johnson, ID Silva, J Peto, H Nevanlinna, TA Muranen, K Aittomaki, C Blomqvist, T Dork, P Schurmann, M Bremer, P Hillemanns, NV Bogdanova, NN Antonenkova, YI Rogov, JH Karstens, E Khusnutdinova, M Bermisheva, D Prokofieva, S Gancev, A Jakubowska, J Lubinski, K Jaworska, K Durda, BG Nordestgaard, SE Bojesen, C Lanng, A Mannermaa, V Kataja, VM Kosma, JM Hartikainen, P Radice, P Peterlongo, S Manoukian, L Bernard, FJ Couch, JE Olson, XS Wang, Z Fredericksen, GG Alnaes, V Kristensen, AL Borresen-Dale, P Devilee, RAEM Tollenaar, Caroline Seynaeve, Maartje Hooning, M Garcia-Closas, SJ Chanock, J Lissowska, ME Sherman, P Hall, JJ Liu, K Czene, D Kang, KY Yoo, DY Noh, A Lindblom, S Margolin, AM Dunning, PDP Pharoah, DF Easton, P Guenel, H Brauch

Medical Oncology

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Research output: Contribution to journal › Article › Academic › peer-review

36 Citations (Scopus)

Abstract

A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 X 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 X 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:11231132, 2012. (c) 2012 Wiley Periodicals, Inc.

Original language	Undefined/Unknown
Pages (from-to)	1123-1132
Number of pages	10
Journal	Human Mutation
Volume	33
Issue number	7
DOIs	https://doi.org/10.1002/humu.22089
Publication status	Published - 2012

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EMC MM-03-86-01

Access to Document

10.1002/humu.22089

http://hdl.handle.net/1765/64152

Cite this

Lambrechts, D., Truong, T., Justenhoven, C., Humphreys, MK., Wang, J., Hopper, JL., Dite, GS., Apicella, C., Southey, MC., Schmidt, M. K., Broeks, A., Cornelissen, S., van Hien, R., Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Milne, RL., Zamora, MP., ... Brauch, H. (2012). 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Human Mutation, 33(7), 1123-1132. https://doi.org/10.1002/humu.22089

@article{99e0411b07b84d6ba7f885d66a45e53d,

title = "11q13 is a susceptibility locus for hormone receptor positive breast cancer",

abstract = "A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 X 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 X 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:11231132, 2012. (c) 2012 Wiley Periodicals, Inc.",

author = "D Lambrechts and T Truong and C Justenhoven and MK Humphreys and Johnny Wang and JL Hopper and GS Dite and C Apicella and MC Southey and Schmidt, \{Marjanka K\} and A Broeks and S Cornelissen and \{van Hien\}, R and E Sawyer and I Tomlinson and M Kerin and N Miller and RL Milne and MP Zamora and JIA Perez and J Benitez and U Hamann and YD Ko and T Bruning and J Chang-Claude and U Eilber and R Hein and S Nickels and D Flesch-Janys and S Wang-Gohrke and EM John and A Miron and R Winqvist and K Pylkas and A Jukkola-Vuorinen and M Grip and G Chenevix-Trench and J Beesley and XQ Chen and F Menegaux and E Cordina-Duverger and CY Shen and JC Yu and PE Wu and MF Hou and IL Andrulis and T Selander and G Glendon and AM Mulligan and H Anton-Culver and A Ziogas and KR Muir and A Lophatananon and S Rattanamongkongul and P Puttawibul and M Jones and N Orr and A Ashworth and A Swerdlow and G Severi and L Baglietto and G Giles and M Southey and F Marme and A Schneeweiss and C Sohn and B Burwinkel and BT Yesilyurt and P Neven and R Paridaens and H Wildiers and H Brenner and H Muller and V Arndt and C Stegmaier and A Meindl and S Schott and CR Bartram and RK Schmutzler and A Cox and IW Brock and G Elliott and SS Cross and PA Fasching and R Schulz-Wendtland and AB Ekici and MW Beckmann and O Fletcher and N Johnson and ID Silva and J Peto and H Nevanlinna and TA Muranen and K Aittomaki and C Blomqvist and T Dork and P Schurmann and M Bremer and P Hillemanns and NV Bogdanova and NN Antonenkova and YI Rogov and JH Karstens and E Khusnutdinova and M Bermisheva and D Prokofieva and S Gancev and A Jakubowska and J Lubinski and K Jaworska and K Durda and BG Nordestgaard and SE Bojesen and C Lanng and A Mannermaa and V Kataja and VM Kosma and JM Hartikainen and P Radice and P Peterlongo and S Manoukian and L Bernard and FJ Couch and JE Olson and XS Wang and Z Fredericksen and GG Alnaes and V Kristensen and AL Borresen-Dale and P Devilee and RAEM Tollenaar and Caroline Seynaeve and Maartje Hooning and M Garcia-Closas and SJ Chanock and J Lissowska and ME Sherman and P Hall and JJ Liu and K Czene and D Kang and KY Yoo and DY Noh and A Lindblom and S Margolin and AM Dunning and PDP Pharoah and DF Easton and P Guenel and H Brauch",

year = "2012",

doi = "10.1002/humu.22089",

language = "Undefined/Unknown",

volume = "33",

pages = "1123--1132",

journal = "Human Mutation",

issn = "1059-7794",

publisher = "John Wiley \& Sons Inc.",

number = "7",

}

Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, MK, Wang, J, Hopper, JL, Dite, GS, Apicella, C, Southey, MC, Schmidt, MK, Broeks, A, Cornelissen, S, van Hien, R, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, RL, Zamora, MP, Perez, JIA, Benitez, J, Hamann, U, Ko, YD, Bruning, T, Chang-Claude, J, Eilber, U, Hein, R, Nickels, S, Flesch-Janys, D, Wang-Gohrke, S, John, EM, Miron, A, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Chenevix-Trench, G, Beesley, J, Chen, XQ, Menegaux, F, Cordina-Duverger, E, Shen, CY, Yu, JC, Wu, PE, Hou, MF, Andrulis, IL, Selander, T, Glendon, G, Mulligan, AM, Anton-Culver, H, Ziogas, A, Muir, KR, Lophatananon, A, Rattanamongkongul, S, Puttawibul, P, Jones, M, Orr, N, Ashworth, A, Swerdlow, A, Severi, G, Baglietto, L, Giles, G, Southey, M, Marme, F, Schneeweiss, A, Sohn, C, Burwinkel, B, Yesilyurt, BT, Neven, P, Paridaens, R, Wildiers, H, Brenner, H, Muller, H, Arndt, V, Stegmaier, C, Meindl, A, Schott, S, Bartram, CR, Schmutzler, RK, Cox, A, Brock, IW, Elliott, G, Cross, SS, Fasching, PA, Schulz-Wendtland, R, Ekici, AB, Beckmann, MW, Fletcher, O, Johnson, N, Silva, ID, Peto, J, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Dork, T, Schurmann, P, Bremer, M, Hillemanns, P, Bogdanova, NV, Antonenkova, NN, Rogov, YI, Karstens, JH, Khusnutdinova, E, Bermisheva, M, Prokofieva, D, Gancev, S, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Nordestgaard, BG, Bojesen, SE, Lanng, C, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Couch, FJ, Olson, JE, Wang, XS, Fredericksen, Z, Alnaes, GG, Kristensen, V, Borresen-Dale, AL, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Hooning, M, Garcia-Closas, M, Chanock, SJ, Lissowska, J, Sherman, ME, Hall, P, Liu, JJ, Czene, K, Kang, D, Yoo, KY, Noh, DY, Lindblom, A, Margolin, S, Dunning, AM, Pharoah, PDP, Easton, DF, Guenel, P & Brauch, H 2012, '11q13 is a susceptibility locus for hormone receptor positive breast cancer', Human Mutation, vol. 33, no. 7, pp. 1123-1132. https://doi.org/10.1002/humu.22089

TY - JOUR

T1 - 11q13 is a susceptibility locus for hormone receptor positive breast cancer

AU - Lambrechts, D

AU - Truong, T

AU - Justenhoven, C

AU - Humphreys, MK

AU - Wang, Johnny

AU - Hopper, JL

AU - Dite, GS

AU - Apicella, C

AU - Southey, MC

AU - Schmidt, Marjanka K

AU - Broeks, A

AU - Cornelissen, S

AU - van Hien, R

AU - Sawyer, E

AU - Tomlinson, I

AU - Kerin, M

AU - Miller, N

AU - Milne, RL

AU - Zamora, MP

AU - Perez, JIA

AU - Benitez, J

AU - Hamann, U

AU - Ko, YD

AU - Bruning, T

AU - Chang-Claude, J

AU - Eilber, U

AU - Hein, R

AU - Nickels, S

AU - Flesch-Janys, D

AU - Wang-Gohrke, S

AU - John, EM

AU - Miron, A

AU - Winqvist, R

AU - Pylkas, K

AU - Jukkola-Vuorinen, A

AU - Grip, M

AU - Chenevix-Trench, G

AU - Beesley, J

AU - Chen, XQ

AU - Menegaux, F

AU - Cordina-Duverger, E

AU - Shen, CY

AU - Yu, JC

AU - Wu, PE

AU - Hou, MF

AU - Andrulis, IL

AU - Selander, T

AU - Glendon, G

AU - Mulligan, AM

AU - Anton-Culver, H

AU - Ziogas, A

AU - Muir, KR

AU - Lophatananon, A

AU - Rattanamongkongul, S

AU - Puttawibul, P

AU - Jones, M

AU - Orr, N

AU - Ashworth, A

AU - Swerdlow, A

AU - Severi, G

AU - Baglietto, L

AU - Giles, G

AU - Southey, M

AU - Marme, F

AU - Schneeweiss, A

AU - Sohn, C

AU - Burwinkel, B

AU - Yesilyurt, BT

AU - Neven, P

AU - Paridaens, R

AU - Wildiers, H

AU - Brenner, H

AU - Muller, H

AU - Arndt, V

AU - Stegmaier, C

AU - Meindl, A

AU - Schott, S

AU - Bartram, CR

AU - Schmutzler, RK

AU - Cox, A

AU - Brock, IW

AU - Elliott, G

AU - Cross, SS

AU - Fasching, PA

AU - Schulz-Wendtland, R

AU - Ekici, AB

AU - Beckmann, MW

AU - Fletcher, O

AU - Johnson, N

AU - Silva, ID

AU - Peto, J

AU - Nevanlinna, H

AU - Muranen, TA

AU - Aittomaki, K

AU - Blomqvist, C

AU - Dork, T

AU - Schurmann, P

AU - Bremer, M

AU - Hillemanns, P

AU - Bogdanova, NV

AU - Antonenkova, NN

AU - Rogov, YI

AU - Karstens, JH

AU - Khusnutdinova, E

AU - Bermisheva, M

AU - Prokofieva, D

AU - Gancev, S

AU - Jakubowska, A

AU - Lubinski, J

AU - Jaworska, K

AU - Durda, K

AU - Nordestgaard, BG

AU - Bojesen, SE

AU - Lanng, C

AU - Mannermaa, A

AU - Kataja, V

AU - Kosma, VM

AU - Hartikainen, JM

AU - Radice, P

AU - Peterlongo, P

AU - Manoukian, S

AU - Bernard, L

AU - Couch, FJ

AU - Olson, JE

AU - Wang, XS

AU - Fredericksen, Z

AU - Alnaes, GG

AU - Kristensen, V

AU - Borresen-Dale, AL

AU - Devilee, P

AU - Tollenaar, RAEM

AU - Seynaeve, Caroline

AU - Hooning, Maartje

AU - Garcia-Closas, M

AU - Chanock, SJ

AU - Lissowska, J

AU - Sherman, ME

AU - Hall, P

AU - Liu, JJ

AU - Czene, K

AU - Kang, D

AU - Yoo, KY

AU - Noh, DY

AU - Lindblom, A

AU - Margolin, S

AU - Dunning, AM

AU - Pharoah, PDP

AU - Easton, DF

AU - Guenel, P

AU - Brauch, H

PY - 2012

Y1 - 2012

N2 - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 X 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 X 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:11231132, 2012. (c) 2012 Wiley Periodicals, Inc.

AB - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 X 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 X 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:11231132, 2012. (c) 2012 Wiley Periodicals, Inc.

U2 - 10.1002/humu.22089

DO - 10.1002/humu.22089

M3 - Article

C2 - 22461340

SN - 1059-7794

VL - 33

SP - 1123

EP - 1132

JO - Human Mutation

JF - Human Mutation

IS - 7

ER -