36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch*, Ajay J. Kirtane, On behalf of the RADIANCE-HTN Investigators, Michel Azizi, Felix Mahfoud, Jan Basile, Joost Daemen, Manish Saxena, Lisa Thackeray, Maureen McGuire, Lisa Claude, Roland E. Schmieder, Arno Ruiter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Endovascular ultrasound renal denervation (uRDN) reduced blood pressure (BP) compared to sham at 2 months in patients with resistant hypertension in the multicenter, blinded, randomized, sham-controlled RADIANCE-HTN TRIO trial. This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (n = 69) or sham (n = 67). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49/69) completed 36-month follow-up. Screening office BP was 159/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153/99 mmHg. At 36 months, office BP changed by −14.5 ± 26.1/−9.0 ± 14.8 mmHg from screening (p < 0.001 for both) and −8.0 ± 24.5/−5.0 ± 14.6 mmHg from baseline (p = 0.007; p = 0.022) on 3.7 AHM. The efficacy of uRDN was durable to 36 months in patients with resistant hypertension with no safety concerns. (Figure presented.)

Original languageEnglish
Pages (from-to)3467-3472
Number of pages6
JournalHypertension Research
Volume47
Issue number12
DOIs
Publication statusPublished - Dec 2024

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