A 40-year-old woman with a progressive periventricular white matter lesion

Jeroen Jong, Hans Stoop, Martin van den Bent, J.M. Kros, Wolter Oosterhuis, LHJ (Leendert) Looijenga

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A 40-year-old woman presented with blurred vision and diplopia, followed by slowly progressive left-sided motor and sensory disturbances. She also suffered from memory loss and had mild spatial and temporal disorientation. A T2-weighted MRI showed a large area of high signal intensity in the periventricular white matter of the right more than the left occipital region and the corpus callosum, without enhancement on T1-weighted images after gadolinium administration and without mass effect. A stereotacticbiopsy of the intracerebral lesion showed blast-like neoplastic cells within a mononuclear infiltrate. No diagnosis could be made based on morphology and immunohistochemistry using a large series of markers. However, based on positive OCT3/4 nuclear staining, the tumor was diagnosed as a germinoma (seminoma of the brain). The patient was treated accordingly and her condition improved, although focal deficits remained.

Original languageEnglish
Pages (from-to)103-104
Number of pages2
JournalBrain Pathology
Issue number1
Publication statusPublished - 22 Jan 2008

Research programs

  • EMC MM-03-24-01
  • EMC MM-03-44-06


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