TY - JOUR
T1 - A case of primary aldosteronism revealed after renal transplantation
AU - Hoorn, Ewout J.
AU - Hesselink, Dennis A.
AU - Kho, Marcia M.
AU - Roodnat, Joke I.
AU - Weimar, Willem
AU - Van Saase, Jan L.
AU - Van Den Meiracker, Anton H.
AU - Zietse, Robert
PY - 2011/1
Y1 - 2011/1
N2 - Background. A 57-year-old woman was referred to a nephrology clinic because of chronic hypokalemia. She had a history of polycystic kidney disease, resistant hypertension, atrial fibrillation, type 2 diabetes, stroke, and end-stage renal disease, and had received a kidney transplant from a deceased donor at the age of 48 years. At presentation, the patient described symptoms of chronic fatigue and muscle aches, but she did not report pareses. Her medications included four antihypertensive agents, glucose-lowering drugs, immunosuppressants, digoxin, a coumarin derivative, and potassium chloride.Investigations. Full history, physical examination, laboratory testing of blood and urine, including aldosterone-torenin ratio, and a saline infusion test.Diagnosis. Primary aldosteronism.Management. Treatment with spironolactone resulted in prompt control of hypertension and hypokalemia, allowing discontinuation of potassium chloride and reduction in antihypertensive medication.
AB - Background. A 57-year-old woman was referred to a nephrology clinic because of chronic hypokalemia. She had a history of polycystic kidney disease, resistant hypertension, atrial fibrillation, type 2 diabetes, stroke, and end-stage renal disease, and had received a kidney transplant from a deceased donor at the age of 48 years. At presentation, the patient described symptoms of chronic fatigue and muscle aches, but she did not report pareses. Her medications included four antihypertensive agents, glucose-lowering drugs, immunosuppressants, digoxin, a coumarin derivative, and potassium chloride.Investigations. Full history, physical examination, laboratory testing of blood and urine, including aldosterone-torenin ratio, and a saline infusion test.Diagnosis. Primary aldosteronism.Management. Treatment with spironolactone resulted in prompt control of hypertension and hypokalemia, allowing discontinuation of potassium chloride and reduction in antihypertensive medication.
UR - http://www.scopus.com/inward/record.url?scp=78650521875&partnerID=8YFLogxK
U2 - 10.1038/nrneph.2010.158
DO - 10.1038/nrneph.2010.158
M3 - Article
C2 - 21102541
SN - 1759-5061
VL - 7
SP - 55
EP - 60
JO - Nature Reviews Nephrology
JF - Nature Reviews Nephrology
IS - 1
ER -
