A cause-specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study

Oisín Bugter; Dirk L.P. van Iwaarden; Nikki van Leeuwen; Daan Nieboer; Emilie A.C. Dronkers; José A.U. Hardillo; Robert J. Baatenburg de Jong

doi:10.1002/hed.26666

A cause-specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study

Oisín Bugter, Dirk L.P. van Iwaarden, Nikki van Leeuwen, Daan Nieboer, Emilie A.C. Dronkers, José A.U. Hardillo^*, Robert J. Baatenburg de Jong

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

11 Downloads (Pure)

Abstract

Background: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. Methods: We collected data from 1581 patients. A cause-specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. Results: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C-index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). Conclusions: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations.

Original language	English
Pages (from-to)	1881-1889
Number of pages	9
Journal	Head and Neck
Volume	43
Issue number	6
Early online date	3 Mar 2021
DOIs	https://doi.org/10.1002/hed.26666
Publication status	Published - Jun 2021

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.26666

Head Neck - 2021 - Bugter - A cause‐specific Cox model for second primary tumors in patients with head and neck cancer ALicence: CC BY-NC-ND

Cite this

@article{e4a0b5f748c140368e8b98b625b16846,

title = "A cause-specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study",

abstract = "Background: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. Methods: We collected data from 1581 patients. A cause-specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. Results: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C-index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). Conclusions: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations.",

author = "Ois{\'i}n Bugter and {van Iwaarden}, {Dirk L.P.} and {van Leeuwen}, Nikki and Daan Nieboer and Dronkers, {Emilie A.C.} and Hardillo, {Jos{\'e} A.U.} and {Baatenburg de Jong}, {Robert J.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2021",

month = jun,

doi = "10.1002/hed.26666",

language = "English",

volume = "43",

pages = "1881--1889",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "6",

}

TY - JOUR

T1 - A cause-specific Cox model for second primary tumors in patients with head and neck cancer

T2 - A RONCDOC study

AU - Bugter, Oisín

AU - van Iwaarden, Dirk L.P.

AU - van Leeuwen, Nikki

AU - Nieboer, Daan

AU - Dronkers, Emilie A.C.

AU - Hardillo, José A.U.

AU - Baatenburg de Jong, Robert J.

PY - 2021/6

Y1 - 2021/6

N2 - Background: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. Methods: We collected data from 1581 patients. A cause-specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. Results: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C-index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). Conclusions: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations.

AB - Background: The aim of this study was to identify risk factors for the development of second primary tumors (SPTs) in the head and neck region, lungs, and esophagus in patients with head and neck cancer. Methods: We collected data from 1581 patients. A cause-specific Cox model for the development of an SPT was fitted, accounting for the competing risks residual/recurrent tumor and mortality. Results: Of all patients, 246 (15.6%) developed SPTs. Analysis showed that tobacco and alcohol use, comorbidity, and the oral cavity subsite were risk factors for SPTs. The C-index, the discriminative accuracy, of the model for SPT was 0.65 (95% confidence interval, 0.61–0.68). Conclusions: Our results show that there is potential to identify patients who have an increased risk to develop an SPT. This might increase their survival chances and quality of life. More research is needed to provide head and neck clinicians with definitive recommendations.

UR - http://www.scopus.com/inward/record.url?scp=85101868632&partnerID=8YFLogxK

U2 - 10.1002/hed.26666

DO - 10.1002/hed.26666

M3 - Article

C2 - 33655596

AN - SCOPUS:85101868632

SN - 1043-3074

VL - 43

SP - 1881

EP - 1889

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

A cause-specific Cox model for second primary tumors in patients with head and neck cancer: A RONCDOC study

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this