A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

KL Huang; E Marcora; AA Pimenova; AF Di Narzo; M Kapoor; SC Jin; O Harari; S Bertelsen; BP Fairfax; J Czajkowski; V Chouraki; B Grenier-Boley; C Bellenguez; Y Deming; A McKenzie; T Raj; AE Renton; J Budde; A Smith; A Fitzpatrick; JC Bis; A DeStefano; Hieab Adams; Arfan Ikram; Sven van der Lee; JL Del-Aguila; MV (Maria Victoria) Fernandez; L Ibanez; R Sims; V Escott-Price; R Mayeux; JL Haines; LA Farrer; MA Pericak-Vance; JC Lambert; Cornelia Duijn; L Launer; S Seshadri; J Williams; P Amouyel; GD Schellenberg; B Zhang; I Borecki; JSK Kauwe; C Cruchaga; K Hao; AM Goate

doi:10.1038/nn.4587

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

KL Huang, E Marcora, AA Pimenova, AF Di Narzo, M Kapoor, SC Jin, O Harari, S Bertelsen, BP Fairfax, J Czajkowski, V Chouraki, B Grenier-Boley, C Bellenguez, Y Deming, A McKenzie, T Raj, AE Renton, J Budde, A Smith, A FitzpatrickJC Bis, A DeStefano, Hieab Adams, Arfan Ikram, Sven van der Lee, JL Del-Aguila, MV (Maria Victoria) Fernandez, L Ibanez, R Sims, V Escott-Price, R Mayeux, JL Haines, LA Farrer, MA Pericak-Vance, JC Lambert, Cornelia Duijn, L Launer, S Seshadri, J Williams, P Amouyel, GD Schellenberg, B Zhang, I Borecki, JSK Kauwe, C Cruchaga, K Hao, AM Goate

Epidemiology

Research output: Contribution to journal › Article › Academic › peer-review

215 Citations (Scopus)

Original language	English
Pages (from-to)	1052-1061
Number of pages	10
Journal	Nature Neuroscience
Volume	20
Issue number	8
DOIs	https://doi.org/10.1038/nn.4587
Publication status	Published - 2017

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10.1038/nn.4587

http://hdl.handle.net/1765/108558

Cite this

Huang, KL., Marcora, E., Pimenova, AA., Di Narzo, AF., Kapoor, M., Jin, SC., Harari, O., Bertelsen, S., Fairfax, BP., Czajkowski, J., Chouraki, V., Grenier-Boley, B., Bellenguez, C., Deming, Y., McKenzie, A., Raj, T., Renton, AE., Budde, J., Smith, A., ... Goate, AM. (2017). A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience, 20(8), 1052-1061. https://doi.org/10.1038/nn.4587

@article{e6bec6363a4a4120a3dc45df11b6dc36,

title = "A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease",

author = "KL Huang and E Marcora and AA Pimenova and {Di Narzo}, AF and M Kapoor and SC Jin and O Harari and S Bertelsen and BP Fairfax and J Czajkowski and V Chouraki and B Grenier-Boley and C Bellenguez and Y Deming and A McKenzie and T Raj and AE Renton and J Budde and A Smith and A Fitzpatrick and JC Bis and A DeStefano and Hieab Adams and Arfan Ikram and {van der Lee}, Sven and JL Del-Aguila and Fernandez, {MV (Maria Victoria)} and L Ibanez and R Sims and V Escott-Price and R Mayeux and JL Haines and LA Farrer and MA Pericak-Vance and JC Lambert and Cornelia Duijn and L Launer and S Seshadri and J Williams and P Amouyel and GD Schellenberg and B Zhang and I Borecki and JSK Kauwe and C Cruchaga and K Hao and AM Goate",

year = "2017",

doi = "10.1038/nn.4587",

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volume = "20",

pages = "1052--1061",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

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Huang, KL, Marcora, E, Pimenova, AA, Di Narzo, AF, Kapoor, M, Jin, SC, Harari, O, Bertelsen, S, Fairfax, BP, Czajkowski, J, Chouraki, V, Grenier-Boley, B, Bellenguez, C, Deming, Y, McKenzie, A, Raj, T, Renton, AE, Budde, J, Smith, A, Fitzpatrick, A, Bis, JC, DeStefano, A, Adams, H , Ikram, A , van der Lee, S, Del-Aguila, JL, Fernandez, MV, Ibanez, L, Sims, R, Escott-Price, V, Mayeux, R, Haines, JL, Farrer, LA, Pericak-Vance, MA, Lambert, JC, Duijn, C, Launer, L, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Zhang, B, Borecki, I, Kauwe, JSK, Cruchaga, C, Hao, K & Goate, AM 2017, 'A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease', Nature Neuroscience, vol. 20, no. 8, pp. 1052-1061. https://doi.org/10.1038/nn.4587

TY - JOUR

T1 - A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

AU - Huang, KL

AU - Marcora, E

AU - Pimenova, AA

AU - Di Narzo, AF

AU - Kapoor, M

AU - Jin, SC

AU - Harari, O

AU - Bertelsen, S

AU - Fairfax, BP

AU - Czajkowski, J

AU - Chouraki, V

AU - Grenier-Boley, B

AU - Bellenguez, C

AU - Deming, Y

AU - McKenzie, A

AU - Raj, T

AU - Renton, AE

AU - Budde, J

AU - Smith, A

AU - Fitzpatrick, A

AU - Bis, JC

AU - DeStefano, A

AU - Adams, Hieab

AU - Ikram, Arfan

AU - van der Lee, Sven

AU - Del-Aguila, JL

AU - Fernandez, MV (Maria Victoria)

AU - Ibanez, L

AU - Sims, R

AU - Escott-Price, V

AU - Mayeux, R

AU - Haines, JL

AU - Farrer, LA

AU - Pericak-Vance, MA

AU - Lambert, JC

AU - Duijn, Cornelia

AU - Launer, L

AU - Seshadri, S

AU - Williams, J

AU - Amouyel, P

AU - Schellenberg, GD

AU - Zhang, B

AU - Borecki, I

AU - Kauwe, JSK

AU - Cruchaga, C

AU - Hao, K

AU - Goate, AM

PY - 2017

Y1 - 2017

U2 - 10.1038/nn.4587

DO - 10.1038/nn.4587

M3 - Article

VL - 20

SP - 1052

EP - 1061

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 8

ER -