A comparative analysis of three widely used lipid management guidelines in the EPIC-Norfolk cohort

EB Colkesen; HT Jorstad; RJG Peters; SM Boekholdt; Kedir Adal; Bart Ferket; NJ Wareham; KT Khaw

doi:10.1177/2047487311435456

A comparative analysis of three widely used lipid management guidelines in the EPIC-Norfolk cohort

EB Colkesen, HT Jorstad, RJG Peters, SM Boekholdt, Kedir Adal, Bart Ferket, NJ Wareham, KT Khaw

Research output: Contribution to journal › Article › Academic

3 Citations (Scopus)

Abstract

Aims: To compare the impact of three major guidelines for the prevention of cardiovascular disease (CVD). Methods and results: 21,263 men and women aged 39-79 years from the EPIC (European Prospective Investigation of Cancer) Norfolk cohort were retrospectively classified at baseline by statin therapy recommendations according to the NICE, ESC and ATPIII CVD prevention guidelines. Recommendations based on baseline data were related to 10-year follow-up to calculate number of new CVD events that could be prevented by statins, number-needed-to-treat (NNT) and CVD incidence decrease. Statin therapy was Conclusions: The NICE guideline selected greater percentages of elderly and subjects with prevalent CVD risk factors. It performed best in recommending statins and could have prevented the greatest number of CVD events. With all guidelines, nearly half the subjects who developed a CVD event were not considered eligible for statins at baseline. Less selective prevention strategies need to be explored.

Original language	Undefined/Unknown
Pages (from-to)	98-106
Number of pages	9
Journal	European Journal of Preventive Cardiology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1177/2047487311435456
Publication status	Published - 2013

Research programs

EMC NIHES-03-30-02

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/2047487311435456

http://hdl.handle.net/1765/73697

Cite this

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title = "A comparative analysis of three widely used lipid management guidelines in the EPIC-Norfolk cohort",

abstract = "Aims: To compare the impact of three major guidelines for the prevention of cardiovascular disease (CVD). Methods and results: 21,263 men and women aged 39-79 years from the EPIC (European Prospective Investigation of Cancer) Norfolk cohort were retrospectively classified at baseline by statin therapy recommendations according to the NICE, ESC and ATPIII CVD prevention guidelines. Recommendations based on baseline data were related to 10-year follow-up to calculate number of new CVD events that could be prevented by statins, number-needed-to-treat (NNT) and CVD incidence decrease. Statin therapy was Conclusions: The NICE guideline selected greater percentages of elderly and subjects with prevalent CVD risk factors. It performed best in recommending statins and could have prevented the greatest number of CVD events. With all guidelines, nearly half the subjects who developed a CVD event were not considered eligible for statins at baseline. Less selective prevention strategies need to be explored.",

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T1 - A comparative analysis of three widely used lipid management guidelines in the EPIC-Norfolk cohort

AU - Colkesen, EB

AU - Jorstad, HT

AU - Peters, RJG

AU - Boekholdt, SM

AU - Adal, Kedir

AU - Ferket, Bart

AU - Wareham, NJ

AU - Khaw, KT

PY - 2013

Y1 - 2013

N2 - Aims: To compare the impact of three major guidelines for the prevention of cardiovascular disease (CVD). Methods and results: 21,263 men and women aged 39-79 years from the EPIC (European Prospective Investigation of Cancer) Norfolk cohort were retrospectively classified at baseline by statin therapy recommendations according to the NICE, ESC and ATPIII CVD prevention guidelines. Recommendations based on baseline data were related to 10-year follow-up to calculate number of new CVD events that could be prevented by statins, number-needed-to-treat (NNT) and CVD incidence decrease. Statin therapy was Conclusions: The NICE guideline selected greater percentages of elderly and subjects with prevalent CVD risk factors. It performed best in recommending statins and could have prevented the greatest number of CVD events. With all guidelines, nearly half the subjects who developed a CVD event were not considered eligible for statins at baseline. Less selective prevention strategies need to be explored.

AB - Aims: To compare the impact of three major guidelines for the prevention of cardiovascular disease (CVD). Methods and results: 21,263 men and women aged 39-79 years from the EPIC (European Prospective Investigation of Cancer) Norfolk cohort were retrospectively classified at baseline by statin therapy recommendations according to the NICE, ESC and ATPIII CVD prevention guidelines. Recommendations based on baseline data were related to 10-year follow-up to calculate number of new CVD events that could be prevented by statins, number-needed-to-treat (NNT) and CVD incidence decrease. Statin therapy was Conclusions: The NICE guideline selected greater percentages of elderly and subjects with prevalent CVD risk factors. It performed best in recommending statins and could have prevented the greatest number of CVD events. With all guidelines, nearly half the subjects who developed a CVD event were not considered eligible for statins at baseline. Less selective prevention strategies need to be explored.

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