Narrow-band ultraviolet-B and pulsed dye laser (PDL) affect psoriasis but via different pathways. To compare the results of PDL with ultraviolet-B light therapy (UVB) and to look for synergism of both therapies in patients with plaque type psoriasis. In each eligible individual, four similar target plaques were selected, and halves of these plaques were treated using PDL, UVB, or a combination of PDL and UVB or were not treated. Results were recorded single-blind using the Physician's Global Assessment score at study enrolment and Week 13. Nonparametric, paired statistical tests were used to test for differences within and between therapies.The results were also analyzed after dichotomization of the changes in the Physician's Global Assessment score into responsive and nonresponsive to treatment. A significant improvement of the psoriasis lesions was noted at Week 13 (P <.001) with each therapy. No significant differences were noted between the therapies. Synergism of PDL and UVB was not observed. PDL is safe for treating plaque type psoriasis, but its efficacy is limited to a subgroup of patients. Combining PDL with UVB has no additional benefit. The authors have indicated no significant interest with commercial supporters.