TY - JOUR
T1 - A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus
AU - Brands, Augustina M. A.
AU - Van den Berg, Esther
AU - Manschot, Sanne M.
AU - Biessels, Geert Jan
AU - Kappelle, L. Jaap
AU - De Haan, Edward H. F.
AU - Kessels, Roy P. C.
PY - 2007/2/2
Y1 - 2007/2/2
N2 - Type 2 diabetes mellitus (DM2) is a common metabolic disorder. DM2 is associated with cognitive impairments, and with depressive symptoms, which occur in about one third of patients. In the current study we compared the cognitive profile and psychological well-being of 119 patients with DM2 (mean age: 66 +/- 6; mean duration: 9 +/- 6 years) with 55 age and education matched-control participants. Groups were compared on cognitive performance in five major cognitive domains, psychological wellbeing [assessed by Symptom Checklist (SCL)-90-R and the Beck Depression Inventory (BDI-II)]. and abnormalities on brain MRI. We hypothesized an interrelationship between cognition, MRI abnormalities, and psychological well-being. DM2 patients performed significantly worse than controls on cognitive tasks, especially on tasks that required more mental efficiency, although the differences were modest (effect sizes Cohen d
AB - Type 2 diabetes mellitus (DM2) is a common metabolic disorder. DM2 is associated with cognitive impairments, and with depressive symptoms, which occur in about one third of patients. In the current study we compared the cognitive profile and psychological well-being of 119 patients with DM2 (mean age: 66 +/- 6; mean duration: 9 +/- 6 years) with 55 age and education matched-control participants. Groups were compared on cognitive performance in five major cognitive domains, psychological wellbeing [assessed by Symptom Checklist (SCL)-90-R and the Beck Depression Inventory (BDI-II)]. and abnormalities on brain MRI. We hypothesized an interrelationship between cognition, MRI abnormalities, and psychological well-being. DM2 patients performed significantly worse than controls on cognitive tasks, especially on tasks that required more mental efficiency, although the differences were modest (effect sizes Cohen d
U2 - 10.1017/S1355617707070312
DO - 10.1017/S1355617707070312
M3 - Article
C2 - 17286886
SN - 1355-6177
VL - 13
SP - 288
EP - 297
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 2
ER -
