A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus

Augustina M. A. Brands*, Esther Van den Berg, Sanne M. Manschot, Geert Jan Biessels, L. Jaap Kappelle, Edward H. F. De Haan, Roy P. C. Kessels

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)

Abstract

Type 2 diabetes mellitus (DM2) is a common metabolic disorder. DM2 is associated with cognitive impairments, and with depressive symptoms, which occur in about one third of patients. In the current study we compared the cognitive profile and psychological well-being of 119 patients with DM2 (mean age: 66 +/- 6; mean duration: 9 +/- 6 years) with 55 age and education matched-control participants. Groups were compared on cognitive performance in five major cognitive domains, psychological wellbeing [assessed by Symptom Checklist (SCL)-90-R and the Beck Depression Inventory (BDI-II)]. and abnormalities on brain MRI. We hypothesized an interrelationship between cognition, MRI abnormalities, and psychological well-being. DM2 patients performed significantly worse than controls on cognitive tasks, especially on tasks that required more mental efficiency, although the differences were modest (effect sizes Cohen d

Original languageEnglish
Pages (from-to)288-297
Number of pages10
JournalJournal of the International Neuropsychological Society
Volume13
Issue number2
DOIs
Publication statusPublished - 2 Feb 2007
Externally publishedYes

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