TY - JOUR
T1 - A first update on mapping the human genetic architecture of COVID-19
AU - The COVID-19 Host Genetics Initiative
AU - AncestryDNA COVID-19 Research Study
AU - BelCovid
AU - Biobanque Quebec COVID-19
AU - CCHC COVID-19 GAWS
AU - CHOP CAG
AU - The Colorado Center for Personalized Medicine
AU - Coronagenes
AU - Egypt hgCOVID hub
AU - EraCORE
AU - The Estonian Biobank Research Team
AU - EXCEED
AU - FinnGen Consortium
AU - Functional Host Genomics in Infectious Diseases (FHoGID)
AU - GCAT Genomes For Life
AU - GEN-COVID Multicenter Study Group
AU - Generation Scotland
AU - Genes & Health Research Team
AU - Genes for Good
AU - Genome-wide assessment of the gene variants associated with severe COVID-19 phenotype in Iran
AU - Host genetic factors in COVID-19 patients in relation to disease susceptibility, disease severity and pharmacogenomics
AU - HUNT
AU - The LifeLines Cohort Study
AU - Mass General Brigham-Host Vulnerability to COVID-19
AU - Michigan Genomics Initiative
AU - Mount Sinai Health System COVID-19 Genomics Initiative
AU - MyCode Health Initiative
AU - Netherlands Twin Register
AU - Penn Medicine Biobank
AU - Saudi Human Genome Program-COVID19
AU - The genetic predisposition to severe COVID-19
AU - The Norwegian Mother, Father and Child Cohort Study
AU - TwinsUK
AU - UK 100,000 Genomes Project (Genomics England)
AU - UK Biobank
AU - UK Blood Donors Cohort
AU - Million Veterans Program
AU - Vanda COVID
AU - Variability in immune response genes and severity of SARS-CoV-2 infection (INMUNGEN-CoV2 study)
AU - Pathak, Gita A.
AU - Karjalainen, Juha
AU - Stevens, Christine
AU - Neale, Benjamin M.
AU - Daly, Mark
AU - Ganna, Andrea
AU - Andrews, Shea J.
AU - Kanai, Masahiro
AU - Cordioli, Mattia
AU - Polimanti, Renato
AU - Harerimana, Nadia
AU - Pirinen, Matti
AU - Liao, Rachel G.
AU - Chwialkowska, Karolina
AU - Trankiem, Amy
AU - Balaconis, Mary K.
AU - Nguyen, Huy
AU - Solomonson, Matthew
AU - Veerapen, Kumar
AU - Wolford, Brooke
AU - Roberts, Genevieve
AU - Park, Danny
AU - Ball, Catherine A.
AU - Coignet, Marie
AU - McCurdy, Shannon
AU - Knight, Spencer
AU - Partha, Raghavendran
AU - Rhead, Brooke
AU - Zhang, Miao
AU - Berkowitz, Nathan
AU - Gaddis, Michael
AU - Noto, Keith
AU - Ruiz, Luong
AU - Pavlovic, Milos
AU - Hong, Eurie L.
AU - Rand, Kristin
AU - Girshick, Ahna
AU - Guturu, Harendra
AU - Baltzell, Asher Haug
AU - Niemi, Mari E.K.
AU - Rahmouni, Souad
AU - Guntz, Julien
AU - Li, Rui
AU - Medina-Gomez, Carolina
AU - Ikram, M. Arfan
AU - Uitterlinden, Andre G.
AU - Hottenga, Jouke Jan
AU - Zhao, Jing Hua
PY - 2022/8/4
Y1 - 2022/8/4
N2 - The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
Here we present meta-analyses bringing together 60 studies from 25 countries for three COVID-19-related phenotypes: [...]
AB - The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
Here we present meta-analyses bringing together 60 studies from 25 countries for three COVID-19-related phenotypes: [...]
UR - https://www.scopus.com/pages/publications/85135433188
U2 - 10.1038/s41586-022-04826-7
DO - 10.1038/s41586-022-04826-7
M3 - Article
C2 - 35922517
AN - SCOPUS:85135433188
SN - 0028-0836
VL - 608
SP - E1-E10
JO - Nature
JF - Nature
IS - 7921
ER -
SDG 3 Good Health and Well-being