A fully Bayesian two-stage model for detecting brain activity in fMRI

Alicia Quirós*, Raquel Montes Diez, Juan A. Hernández

*Corresponding author for this work

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

3 Citations (Scopus)

Abstract

Functional Magnetic Resonance Imaging (fMRI) is a non-invasive technique for obtaining a series of images over time under a certain stimulation paradigm. We are interested in identifying regions of brain activity by observing differences in blood magnetism due to haemodynamic response to such stimulus. Here, we extend Kornak (2000) work by proposing a fully Bayesian two-stage model for detecting brain activity in fMRI. The only assumptions that the model makes about the activated areas is that they emit higher signals in response to an stimulus than non-activated areas do, and that they form connected regions, providing a framework for detecting activity much as a neurologist might. Due to the model complexity and following the Bayesian paradigm, we use Markov chain Monte Carlo (MCMC) methods to make inference over the parameters. A simulated study is used to check the model applicability and sensitivity.

Original languageEnglish
Title of host publicationBiological and Medical Data Analysis - 7th International Symposium, ISBMDA 2006, Proceedings
Pages334-345
Number of pages12
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event7th International Symposium on Biological and Medical Data Analysis, ISBMDA 2006 - Thessaloniki, Greece
Duration: 7 Dec 20068 Dec 2006

Publication series

SeriesLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4345 LNBI
ISSN0302-9743

Conference

Conference7th International Symposium on Biological and Medical Data Analysis, ISBMDA 2006
Country/TerritoryGreece
CityThessaloniki
Period7/12/068/12/06

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