A genetic variant in SLC6A20 is associated with Type 2 diabetes in white-European and Chinese populations

Y Ling, Thijs Herpt, Mandy van Hoek, Abbas Dehghan, Bert Hofman, André Uitterlinden, S Jiang, AG Lieverse, B Bravenboer, Difei Lu, Cornelia Duijn, X Gao, E.J.G. Sijbrands

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7 Citations (Scopus)

Abstract

AimsTo investigate whether polymorphisms in SLC6A20 are associated with susceptibility to Type 2 diabetes. MethodsIn the Rotterdam Study, a prospective, population-based cohort (n=5974), 22 tagging polymorphisms with minor allele frequencies>0.05 across SLC6A20 were studied. Replication studies were performed in an independent Dutch case-control study (DiaGene-Rotterdam Study 2 n=3133), and in a Chinese Han case-control population (n=2279). A meta-analysis of the results was performed. ResultsIn the Rotterdam study, the minor alleles of rs13062383, rs10461016 and rs2286489 increased the risk of Type 2 diabetes (hazard ratio 1.37, 95% CI 1.15-1.63, hazard ratio 1.30 95% CI 1.09-1.54 and hazard ratio 1.20, 95% CI 1.07-1.35, respectively). In the DiaGene/Rotterdam Study 2, the A allele of rs13062383 increased the risk of Type 2 diabetes (odds ratio 1.45, 95% CI 1.19-1.76). In the Chinese Han study, the rs13062383 A allele also increased the risk of Type 2 diabetes (odds ratio 1.21, 95% CI 1.03-1.42). Meta-analysis showed a highly significant association of rs13062383 with Type 2 diabetes (odds ratio 1.35, 95% CI 1.21-1.47; P=3.3x10(-8)). ConclusionsIn conclusion, rs13062383 in SLC6A20 increased the susceptibility to Type 2 diabetes in populations with different genetic backgrounds.
Original languageUndefined/Unknown
Pages (from-to)1350-1356
Number of pages7
JournalDiabetic Medicine
Volume31
Issue number11
DOIs
Publication statusPublished - 2014

Research programs

  • EMC COEUR-09
  • EMC MM-01-39-09-A
  • EMC NIHES-01-64-01

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