A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project

F Marroni, A Pfeufer, YS Aulchenko, CS Franklin, Aaron Isaacs, I Pichler, SH Wild, Ben Oostra, AF Wright, H Campbell, JCM Witteman, S Kaab, AA Hicks, U Gyllensten, I Rudan, T Meitinger, C Pattaro, Cornelia Duijn, JF Wilson, PP Pramstaller

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Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)
Original languageUndefined/Unknown
Pages (from-to)322-U48
JournalCirculation-cardiovascular genetics
Issue number4
Publication statusPublished - 2009

Research programs

  • EMC MGC-02-96-01
  • EMC NIHES-01-64-02

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