A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project

F Marroni; A Pfeufer; YS Aulchenko; CS Franklin; Aaron Isaacs; I Pichler; SH Wild; Ben Oostra; AF Wright; H Campbell; JCM Witteman; S Kaab; AA Hicks; U Gyllensten; I Rudan; T Meitinger; C Pattaro; Cornelia Duijn; JF Wilson; PP Pramstaller

doi:10.1161/CIRCGENETICS.108.833806

A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project

F Marroni, A Pfeufer, YS Aulchenko, CS Franklin, Aaron Isaacs, I Pichler, SH Wild, Ben Oostra, AF Wright, H Campbell, JCM Witteman, S Kaab, AA Hicks, U Gyllensten, I Rudan, T Meitinger, C Pattaro, Cornelia Duijn, JF Wilson, PP Pramstaller

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Abstract

Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)

Original language	Undefined/Unknown
Pages (from-to)	322-U48
Journal	Circulation-cardiovascular genetics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1161/CIRCGENETICS.108.833806
Publication status	Published - 2009

Research programs

EMC MGC-02-96-01
EMC NIHES-01-64-02

Access to Document

10.1161/CIRCGENETICS.108.833806

http://hdl.handle.net/1765/25275

Cite this

Marroni, F., Pfeufer, A., Aulchenko, YS., Franklin, CS., Isaacs, A., Pichler, I., Wild, SH., Oostra, B., Wright, AF., Campbell, H., Witteman, JCM., Kaab, S., Hicks, AA., Gyllensten, U., Rudan, I., Meitinger, T., Pattaro, C., Duijn, C., Wilson, JF., & Pramstaller, PP. (2009). A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project. Circulation-cardiovascular genetics, 2(4), 322-U48. https://doi.org/10.1161/CIRCGENETICS.108.833806

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title = "A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project",

abstract = "Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)",

author = "F Marroni and A Pfeufer and YS Aulchenko and CS Franklin and Aaron Isaacs and I Pichler and SH Wild and Ben Oostra and AF Wright and H Campbell and JCM Witteman and S Kaab and AA Hicks and U Gyllensten and I Rudan and T Meitinger and C Pattaro and Cornelia Duijn and JF Wilson and PP Pramstaller",

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doi = "10.1161/CIRCGENETICS.108.833806",

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Marroni, F, Pfeufer, A, Aulchenko, YS, Franklin, CS, Isaacs, A, Pichler, I, Wild, SH, Oostra, B, Wright, AF, Campbell, H, Witteman, JCM, Kaab, S, Hicks, AA, Gyllensten, U, Rudan, I, Meitinger, T, Pattaro, C, Duijn, C, Wilson, JF & Pramstaller, PP 2009, 'A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project', Circulation-cardiovascular genetics, vol. 2, no. 4, pp. 322-U48. https://doi.org/10.1161/CIRCGENETICS.108.833806

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T1 - A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project

AU - Marroni, F

AU - Pfeufer, A

AU - Aulchenko, YS

AU - Franklin, CS

AU - Isaacs, Aaron

AU - Pichler, I

AU - Wild, SH

AU - Oostra, Ben

AU - Wright, AF

AU - Campbell, H

AU - Witteman, JCM

AU - Kaab, S

AU - Hicks, AA

AU - Gyllensten, U

AU - Rudan, I

AU - Meitinger, T

AU - Pattaro, C

AU - Duijn, Cornelia

AU - Wilson, JF

AU - Pramstaller, PP

PY - 2009

Y1 - 2009

N2 - Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)

AB - Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)

U2 - 10.1161/CIRCGENETICS.108.833806

DO - 10.1161/CIRCGENETICS.108.833806

M3 - Article

C2 - 20031603

SN - 1942-325X

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SP - 322-U48

JO - Circulation-cardiovascular genetics

JF - Circulation-cardiovascular genetics

IS - 4

ER -