A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

RA Scott; DF Freitag; Li Li; AY Chu; P Surendran; R Young; N Grarup; A Stancakova; YN Chen; TV Varga; H Yaghootkar; JA Luan; JH Zhao; SM Willems; J Wessel; S Wang; N Maruthur; K Michailidou; A Pirie; Sven van der Lee; C Gillson; A A Al Olama; P Amouyel; L Arriola; D Arveiler; I Aviles-Olmos; B Balkau; A Barricarte; I Barroso; S B Garcia; JC Bis; S Blankenberg; M Boehnke; H Boeing; E Boerwinkle; IB Borecki; J Bork-Jensen; S Bowden; C Caldas; M Caslake; LA Cupples; C Cruchaga; J Czajkowski; M den Hoed; JA Dunn; HM Earl; GB Ehret; E Ferrannini; J Ferrieres; T Foltynie; I Ford; NG Forouhi; F Gianfagna; C Gonzalez; S Grioni; L Hiller; JH Jansson; ME Jorgensen; JW Jukema; R Kaaks; F Kee; ND Kerrison; TJ Key; J Kontto; Z Kote-Jarai; AT Kraja; K Kuulasmaa; J Kuusisto; A Linneberg; CY Liu; G Marenne; KL Mohlke; AP Morris; K Muir; M Muller-Nurasyid; PB Munroe; C Navarro; SF Nielsen; PM Nilsson; BG Nordestgaard; CJ Packard; D Palli; S Panico; GM Peloso; M Perola; A Peters; CJ Poole; JR Quiros; O Rolandsson; C Sacerdote; V Salomaa; MJ Sanchez; N Sattar; SJ Sharp; R Sims; N Slimani; JA Smith; DJ Thompson; S Trompet; R Tumino; DL van der A; YT van der Schouw; J Virtamo; M Walker; K Walter; JE Abraham; L T Amundadottir; JL Aponte; A Butterworth; J Dupuis; DF Easton; RA Eeles; J Erdmann; PW Franks; TM Frayling; T Hansen; JMM Howson; T Jorgensen; J Kooner; M Laakso; C Langenberg; MI McCarthy; JS Pankow; O Pedersen; E Riboli; JI Rotter; D Saleheen; NJ Samani; H Schunkert; P Vollenweider; S O'Rahilly; P Deloukas; J Danesh; MO Goodarzi; S Kathiresan; JB Meigs; MG Ehm; NJ Wareham; DM Waterworth

doi:10.1126/scitranslmed.aad3744

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

RA Scott, DF Freitag, Li Li, AY Chu, P Surendran, R Young, N Grarup, A Stancakova, YN Chen, TV Varga, H Yaghootkar, JA Luan, JH Zhao, SM Willems, J Wessel, S Wang, N Maruthur, K Michailidou, A Pirie, Sven van der LeeC Gillson, A A Al Olama, P Amouyel, L Arriola, D Arveiler, I Aviles-Olmos, B Balkau, A Barricarte, I Barroso, S B Garcia, JC Bis, S Blankenberg, M Boehnke, H Boeing, E Boerwinkle, IB Borecki, J Bork-Jensen, S Bowden, C Caldas, M Caslake, LA Cupples, C Cruchaga, J Czajkowski, M den Hoed, JA Dunn, HM Earl, GB Ehret, E Ferrannini, J Ferrieres, T Foltynie, I Ford, NG Forouhi, F Gianfagna, C Gonzalez, S Grioni, L Hiller, JH Jansson, ME Jorgensen, JW Jukema, R Kaaks, F Kee, ND Kerrison, TJ Key, J Kontto, Z Kote-Jarai, AT Kraja, K Kuulasmaa, J Kuusisto, A Linneberg, CY Liu, G Marenne, KL Mohlke, AP Morris, K Muir, M Muller-Nurasyid, PB Munroe, C Navarro, SF Nielsen, PM Nilsson, BG Nordestgaard, CJ Packard, D Palli, S Panico, GM Peloso, M Perola, A Peters, CJ Poole, JR Quiros, O Rolandsson, C Sacerdote, V Salomaa, MJ Sanchez, N Sattar, SJ Sharp, R Sims, N Slimani, JA Smith, DJ Thompson, S Trompet, R Tumino, DL van der A, YT van der Schouw, J Virtamo, M Walker, K Walter, JE Abraham, L T Amundadottir, JL Aponte, A Butterworth, J Dupuis, DF Easton, RA Eeles, J Erdmann, PW Franks, TM Frayling, T Hansen, JMM Howson, T Jorgensen, J Kooner, M Laakso, C Langenberg, MI McCarthy, JS Pankow, O Pedersen, E Riboli, JI Rotter, D Saleheen, NJ Samani, H Schunkert, P Vollenweider, S O'Rahilly, P Deloukas, J Danesh, MO Goodarzi, S Kathiresan, JB Meigs, MG Ehm, NJ Wareham, DM Waterworth

Research output: Contribution to journal › Article › Academic › peer-review

94 Citations (Scopus)

Original language	Undefined/Unknown
Article number	341ra76
Journal	Science Translational Medicine
Volume	8
Issue number	341
DOIs	https://doi.org/10.1126/scitranslmed.aad3744
Publication status	Published - 2016

Research programs

EMC NIHES-01-64-01

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10.1126/scitranslmed.aad3744

http://hdl.handle.net/1765/96256

Cite this

Scott, RA., Freitag, DF., Li, L., Chu, AY., Surendran, P., Young, R., Grarup, N., Stancakova, A., Chen, YN., Varga, TV., Yaghootkar, H., Luan, JA., Zhao, JH., Willems, SM., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., ... Waterworth, DM. (2016). A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine, 8(341), Article 341ra76. https://doi.org/10.1126/scitranslmed.aad3744

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doi = "10.1126/scitranslmed.aad3744",

language = "Undefined/Unknown",

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journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

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Scott, RA, Freitag, DF, Li, L, Chu, AY, Surendran, P, Young, R, Grarup, N, Stancakova, A, Chen, YN, Varga, TV, Yaghootkar, H, Luan, JA, Zhao, JH, Willems, SM, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, van der Lee, S, Gillson, C, Al Olama, AA, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, SB, Bis, JC, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, IB, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, LA, Cruchaga, C, Czajkowski, J, den Hoed, M, Dunn, JA, Earl, HM, Ehret, GB, Ferrannini, E, Ferrieres, J, Foltynie, T, Ford, I, Forouhi, NG, Gianfagna, F, Gonzalez, C, Grioni, S, Hiller, L, Jansson, JH, Jorgensen, ME, Jukema, JW, Kaaks, R, Kee, F, Kerrison, ND, Key, TJ, Kontto, J, Kote-Jarai, Z, Kraja, AT, Kuulasmaa, K, Kuusisto, J, Linneberg, A, Liu, CY, Marenne, G, Mohlke, KL, Morris, AP, Muir, K, Muller-Nurasyid, M, Munroe, PB, Navarro, C, Nielsen, SF, Nilsson, PM, Nordestgaard, BG, Packard, CJ, Palli, D, Panico, S, Peloso, GM, Perola, M, Peters, A, Poole, CJ, Quiros, JR, Rolandsson, O, Sacerdote, C, Salomaa, V, Sanchez, MJ, Sattar, N, Sharp, SJ, Sims, R, Slimani, N, Smith, JA, Thompson, DJ, Trompet, S, Tumino, R, van der A, DL, van der Schouw, YT, Virtamo, J, Walker, M, Walter, K, Abraham, JE, Amundadottir, LT, Aponte, JL, Butterworth, A, Dupuis, J, Easton, DF, Eeles, RA, Erdmann, J, Franks, PW, Frayling, TM, Hansen, T, Howson, JMM, Jorgensen, T, Kooner, J, Laakso, M, Langenberg, C, McCarthy, MI, Pankow, JS, Pedersen, O, Riboli, E, Rotter, JI, Saleheen, D, Samani, NJ, Schunkert, H, Vollenweider, P, O'Rahilly, S, Deloukas, P, Danesh, J, Goodarzi, MO, Kathiresan, S, Meigs, JB, Ehm, MG, Wareham, NJ & Waterworth, DM 2016, 'A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease', Science Translational Medicine, vol. 8, no. 341, 341ra76. https://doi.org/10.1126/scitranslmed.aad3744

TY - JOUR

T1 - A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

AU - Scott, RA

AU - Freitag, DF

AU - Li, Li

AU - Chu, AY

AU - Surendran, P

AU - Young, R

AU - Grarup, N

AU - Stancakova, A

AU - Chen, YN

AU - Varga, TV

AU - Yaghootkar, H

AU - Luan, JA

AU - Zhao, JH

AU - Willems, SM

AU - Wessel, J

AU - Wang, S

AU - Maruthur, N

AU - Michailidou, K

AU - Pirie, A

AU - van der Lee, Sven

AU - Gillson, C

AU - Al Olama, A A

AU - Amouyel, P

AU - Arriola, L

AU - Arveiler, D

AU - Aviles-Olmos, I

AU - Balkau, B

AU - Barricarte, A

AU - Barroso, I

AU - Garcia, S B

AU - Bis, JC

AU - Blankenberg, S

AU - Boehnke, M

AU - Boeing, H

AU - Boerwinkle, E

AU - Borecki, IB

AU - Bork-Jensen, J

AU - Bowden, S

AU - Caldas, C

AU - Caslake, M

AU - Cupples, LA

AU - Cruchaga, C

AU - Czajkowski, J

AU - den Hoed, M

AU - Dunn, JA

AU - Earl, HM

AU - Ehret, GB

AU - Ferrannini, E

AU - Ferrieres, J

AU - Foltynie, T

AU - Ford, I

AU - Forouhi, NG

AU - Gianfagna, F

AU - Gonzalez, C

AU - Grioni, S

AU - Hiller, L

AU - Jansson, JH

AU - Jorgensen, ME

AU - Jukema, JW

AU - Kaaks, R

AU - Kee, F

AU - Kerrison, ND

AU - Key, TJ

AU - Kontto, J

AU - Kote-Jarai, Z

AU - Kraja, AT

AU - Kuulasmaa, K

AU - Kuusisto, J

AU - Linneberg, A

AU - Liu, CY

AU - Marenne, G

AU - Mohlke, KL

AU - Morris, AP

AU - Muir, K

AU - Muller-Nurasyid, M

AU - Munroe, PB

AU - Navarro, C

AU - Nielsen, SF

AU - Nilsson, PM

AU - Nordestgaard, BG

AU - Packard, CJ

AU - Palli, D

AU - Panico, S

AU - Peloso, GM

AU - Perola, M

AU - Peters, A

AU - Poole, CJ

AU - Quiros, JR

AU - Rolandsson, O

AU - Sacerdote, C

AU - Salomaa, V

AU - Sanchez, MJ

AU - Sattar, N

AU - Sharp, SJ

AU - Sims, R

AU - Slimani, N

AU - Smith, JA

AU - Thompson, DJ

AU - Trompet, S

AU - Tumino, R

AU - van der A, DL

AU - van der Schouw, YT

AU - Virtamo, J

AU - Walker, M

AU - Walter, K

AU - Abraham, JE

AU - Amundadottir, L T

AU - Aponte, JL

AU - Butterworth, A

AU - Dupuis, J

AU - Easton, DF

AU - Eeles, RA

AU - Erdmann, J

AU - Franks, PW

AU - Frayling, TM

AU - Hansen, T

AU - Howson, JMM

AU - Jorgensen, T

AU - Kooner, J

AU - Laakso, M

AU - Langenberg, C

AU - McCarthy, MI

AU - Pankow, JS

AU - Pedersen, O

AU - Riboli, E

AU - Rotter, JI

AU - Saleheen, D

AU - Samani, NJ

AU - Schunkert, H

AU - Vollenweider, P

AU - O'Rahilly, S

AU - Deloukas, P

AU - Danesh, J

AU - Goodarzi, MO

AU - Kathiresan, S

AU - Meigs, JB

AU - Ehm, MG

AU - Wareham, NJ

AU - Waterworth, DM

PY - 2016

Y1 - 2016

U2 - 10.1126/scitranslmed.aad3744

DO - 10.1126/scitranslmed.aad3744

M3 - Article

C2 - 27252175

SN - 1946-6234

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 341

M1 - 341ra76

ER -