A haploscope based binocular pupillometer system to quantify the dynamics of direct and consensual Pupillary Light Reflex

Najiya S.K. Meethal; Deepmala Mazumdar; Sergii Morshchavka; Jasper Robben; J. van der Steen; Ronnie George; Johan J.M. Pel

doi:10.1038/s41598-021-00434-z

A haploscope based binocular pupillometer system to quantify the dynamics of direct and consensual Pupillary Light Reflex

Najiya S.K. Meethal, Deepmala Mazumdar, Sergii Morshchavka, Jasper Robben, J. van der Steen, Ronnie George, Johan J.M. Pel^*

^*Corresponding author for this work

Neurosciences

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Abstract

This study described the development of a haploscope-based pupillometer for the parametrization of the Pupillary Light Reflex (PLR), and its feasibility in a set of 30 healthy subjects (light or dark-colored irides) and five patients diagnosed with Relative Afferent Pupillary Defect (RAPD). Our supplementary aim focused on evaluating the influence of iris colour on the PLR to decide whether a difference in PLR parameters should be anticipated when this system is used across ethnicities. All the participants underwent a customized pupillometry protocol and the generated pupil traces, captured by an eye tracker, were analyzed using exponential fits to derive PLR parameters. A Pupil Response Symmetry (PRS) coefficient was calculated to predict the presence of RAPD. The mean (SD) Initial PD during dilation (3.2 (0.5) mm) and the minimum PD during constriction (2.9 (0.4) mm) in the light iris group had a statistically significant (p < 0.001) higher magnitude compared to the dark iris group. The normal limits of the PRS coefficient ranged from − 0.20 to + 1.07 and all RAPD patients were outside the calculated normal limits. This proposed system, analysis strategies, and the tested metrics showed good short-term repeatability and the potential in detecting pupil abnormalities in neuro-ophthalmic diseases.

Original language	English
Article number	21090
Journal	Scientific Reports
Volume	11
Issue number	1
Early online date	26 Oct 2021
DOIs	https://doi.org/10.1038/s41598-021-00434-z
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
This research was supported by Glaucoomfonds, Oogfonds, Rotterdamse Stichting Blindenbelangen, and Sticht-ing Blindenhulp contributed through UitZicht. The funding organizations had no role in the design or conduct of this research. They provided unrestricted grants.

Publisher Copyright:
© 2021, The Author(s).

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A haploscope based binocular pupillometer system to quantify the dynamics of direct and consensual Pupillary Light ReflexFinal published version, 1.5 MBLicence: CC BY

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title = "A haploscope based binocular pupillometer system to quantify the dynamics of direct and consensual Pupillary Light Reflex",

abstract = "This study described the development of a haploscope-based pupillometer for the parametrization of the Pupillary Light Reflex (PLR), and its feasibility in a set of 30 healthy subjects (light or dark-colored irides) and five patients diagnosed with Relative Afferent Pupillary Defect (RAPD). Our supplementary aim focused on evaluating the influence of iris colour on the PLR to decide whether a difference in PLR parameters should be anticipated when this system is used across ethnicities. All the participants underwent a customized pupillometry protocol and the generated pupil traces, captured by an eye tracker, were analyzed using exponential fits to derive PLR parameters. A Pupil Response Symmetry (PRS) coefficient was calculated to predict the presence of RAPD. The mean (SD) Initial PD during dilation (3.2 (0.5) mm) and the minimum PD during constriction (2.9 (0.4) mm) in the light iris group had a statistically significant (p < 0.001) higher magnitude compared to the dark iris group. The normal limits of the PRS coefficient ranged from − 0.20 to + 1.07 and all RAPD patients were outside the calculated normal limits. This proposed system, analysis strategies, and the tested metrics showed good short-term repeatability and the potential in detecting pupil abnormalities in neuro-ophthalmic diseases.",

author = "Meethal, {Najiya S.K.} and Deepmala Mazumdar and Sergii Morshchavka and Jasper Robben and {van der Steen}, J. and Ronnie George and Pel, {Johan J.M.}",

note = "Funding Information: This research was supported by Glaucoomfonds, Oogfonds, Rotterdamse Stichting Blindenbelangen, and Sticht-ing Blindenhulp contributed through UitZicht. The funding organizations had no role in the design or conduct of this research. They provided unrestricted grants. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Robben, Jasper

AU - van der Steen, J.

AU - George, Ronnie

AU - Pel, Johan J.M.

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A haploscope based binocular pupillometer system to quantify the dynamics of direct and consensual Pupillary Light Reflex

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