A highly virulent variant of HIV-1 circulating in the Netherlands

ATHENA National HIV Observational Cohort; Chris Wymant; Daniela Bezemer; Peter Reiss; Christophe Frazer

doi:10.1126/science.abk1688

A highly virulent variant of HIV-1 circulating in the Netherlands

ATHENA National HIV Observational Cohort, Chris Wymant^*, Daniela Bezemer, Peter Reiss, Christophe Frazer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Abstract

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

Original language	English
Article number	A30
Pages (from-to)	540-545
Number of pages	6
Journal	Science
Volume	375
Issue number	6580
DOIs	https://doi.org/10.1126/science.abk1688
Publication status	Published - 4 Feb 2022

Bibliographical note

Funding Information:
This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment.

Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1126/science.abk1688

Cite this

@article{74b234fa6ef54215a98735547bc3fa5a,

title = "A highly virulent variant of HIV-1 circulating in the Netherlands",

abstract = "We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.",

author = "{ATHENA National HIV Observational Cohort} and Bax, {H I} and {de Jong-Peltenburg}, {N C} and {van Nood}, E and Nouwen, {J L} and Rijnders, {B J A} and C Rokx and Schurink, {C A M} and L Slobbe and A Verbon and N Bassant and {van Beek}, {J E A} and M Vriesde and {van Zonneveld}, {L M} and {de Groot}, J and Boucher, {C A B} and Koopmans, {M P G} and {van Kampen}, {J J A} and Fraaij, {P L A} and {van Rossum}, {A M C} and Vermont, {C L} and {van der Knaap}, {L C} and E Visser and Chris Wymant and Daniela Bezemer and Peter Reiss and Christophe Frazer and T.E.M.S. Sluijs and {van Gorp}, Eric and {Mendonca Melo}, Mariana",

note = "Funding Information: This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment. Publisher Copyright: Copyright {\textcopyright} 2022 The Authors, some rights reserved.",

year = "2022",

month = feb,

day = "4",

doi = "10.1126/science.abk1688",

language = "English",

volume = "375",

pages = "540--545",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6580",

}

TY - JOUR

T1 - A highly virulent variant of HIV-1 circulating in the Netherlands

AU - ATHENA National HIV Observational Cohort

AU - Bax, H I

AU - de Jong-Peltenburg, N C

AU - van Nood, E

AU - Nouwen, J L

AU - Rijnders, B J A

AU - Rokx, C

AU - Schurink, C A M

AU - Slobbe, L

AU - Verbon, A

AU - Bassant, N

AU - van Beek, J E A

AU - Vriesde, M

AU - van Zonneveld, L M

AU - de Groot, J

AU - Boucher, C A B

AU - Koopmans, M P G

AU - van Kampen, J J A

AU - Fraaij, P L A

AU - van Rossum, A M C

AU - Vermont, C L

AU - van der Knaap, L C

AU - Visser, E

AU - Wymant, Chris

AU - Bezemer, Daniela

AU - Reiss, Peter

AU - Frazer, Christophe

AU - Sluijs, T.E.M.S.

AU - van Gorp, Eric

AU - Mendonca Melo, Mariana

N1 - Funding Information: This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment. Publisher Copyright: Copyright © 2022 The Authors, some rights reserved.

PY - 2022/2/4

Y1 - 2022/2/4

N2 - We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

AB - We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

UR - http://www.scopus.com/inward/record.url?scp=85124019619&partnerID=8YFLogxK

U2 - 10.1126/science.abk1688

DO - 10.1126/science.abk1688

M3 - Article

C2 - 35113714

SN - 0036-8075

VL - 375

SP - 540

EP - 545

JO - Science

JF - Science

IS - 6580

M1 - A30

ER -

A highly virulent variant of HIV-1 circulating in the Netherlands

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this