Abstract
Prevention is an attractive solution for the staggering and increasingly unmanageable burden of osteoarthritis. Despite this, the field of osteoarthritis prevention is relatively immature. To date, most of what is known about preventing osteoarthritis and risk factors for osteoarthritis is relative to the disease (underlying biology and pathophysiology) of osteoarthritis, with few studies considering risk factors for osteoarthritis illness, the force driving the personal, financial and societal burden. In this narrative review we will discuss what is known about osteoarthritis prevention, propose actionable prevention strategies related to obesity and joint injury which have emerged as important modifiable risk factors, identify where evidence is lacking, and give insight into what might be possible in terms of prevention by focussing on a lifespan approach to the illness of osteoarthritis, as opposed to a structural disease of the elderly. By targeting a non-specialist audience including scientists, clinicians, students, industry employees and others that are interested in osteoarthritis but who do not necessarily focus on osteoarthritis, the goal is to generate discourse and motivate inquiry which propel the field of osteoarthritis prevention into the mainstream.
| Original language | English |
|---|---|
| Pages (from-to) | 1638-1653 |
| Number of pages | 16 |
| Journal | Osteoarthritis and Cartilage |
| Volume | 29 |
| Issue number | 12 |
| Early online date | 21 Sept 2021 |
| DOIs | |
| Publication status | Published - Dec 2021 |
Bibliographical note
Funding Information:Dr. Whittaker is supported by a Michael Smith Foundation or Health Research Scholar Award and Arthritis STARS Career Development Award. She also holds grants from the BC SUPPORT Unit, and Canadian MSK Rehab Network, outside the submitted work. Dr. Runhaar has nothing to disclose. Dr. Bierma-Zeinstra reports grants from Dutch Arthritis Association, the Netherlands Organization for Health research and development, FOREUM, and EU as well as personal fees from Pfizer and Osteoarthritis & Cartilage, outside of the submitted work. Dr. Roos is the deputy editor of Osteoarthritis and Cartilage, developer of Knee injury and Osteoarthritis Outcome Score (KOOS) and several other freely available patient-reported outcome measures, and founder of the Good Life with Osteoarthritis in Denmark (GLA:D), a not-for profit initiative to implement clinical guidelines in primary care.
Publisher Copyright:
© 2021 Osteoarthritis Research Society International
