A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

Paul B. Essers, Julie Nonnekens, Yvonne J. Goos, Marco C. Betist, Marjon D. Viester, Britt Mossink, Nico Lansu, Hendrik C. Korswagen, Rob Jelier, Arjan B. Brenkman, Alyson W. MacInnes*

*Corresponding author for this work

Research output: Book/Report/Inaugural speech/Farewell speechReportAcademic

45 Citations (Scopus)
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Abstract

The biogenesis of ribosomes and their coordination of protein translation consume an enormous amount of cellular energy. As such, it has been established that the inhibition of either process can extend eukaryotic lifespan. Here, we used next-generation sequencing to compare ribosome-associated RNAs from normal strains of Caenorhabditis elegans to those carrying the life-extending daf-2 mutation. We found a long noncoding RNA (lncRNA), transcribed telomeric sequence 1 ( tts-1), on ribosomes of the daf-2 mutant. Depleting tts-1 in daf-2 mutants increases ribosome levels and significantly shortens their extended lifespan. We find tts-1 is also required for the longer lifespan of the mitochondrial clk-1 mutants but not the feeding-defective eat-2 mutants. In line with this, the clk-1 mutants express more tts-1 and fewer ribosomes than the eat-2 mutants. Our results suggest that the expression of tts-1 functions in different longevity pathways to reduce ribosome levels in a way that promotes life extension.

Original languageEnglish
Number of pages7
Volume10
Edition3
DOIs
Publication statusPublished - 20 Jan 2015
Externally publishedYes

Publication series

SeriesCell Reports
ISSN2211-1247

Bibliographical note

Publisher Copyright:
© 2015 The Authors.

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