TY - JOUR
T1 - A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia
AU - Fongang, Bernard
AU - Weinstein, Galit
AU - Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
AU - Guðjónsson, Alexander
AU - Mishra, Aniket
AU - Bis, Josh C.
AU - Yang, Qiong
AU - Winsvold, Bendik
AU - Sargurupremraj, Muralidharan
AU - Fan, Kang Hsien
AU - Kamboh, M. Ilyas
AU - Li, Gloria
AU - Yang, Jingyun
AU - Hilal, Saima
AU - Satizabal, Claudia L.
AU - Jian, Xueqiu
AU - Knol, Maria J.
AU - Concas, Maria Pina
AU - Girotto, Giorgia
AU - Riaz, Moeen
AU - Lacaze, Paul
AU - Ruiz, Agustín
AU - Naj, Adam C.
AU - Schellenberg, Gerard D.
AU - Kehoe, Patrick G.
AU - Van Der Lee, Sven J.
AU - Skrobot, Olivia Anna
AU - Gudnason, Vilmundur
AU - Lopez, Oscar L.
AU - Haan, Mary
AU - Bosnes, Ingunn
AU - Dufouil, Carole
AU - Ganguli, Mary
AU - Cheung, Ching Lung
AU - Bennett, David A.
AU - Lambert, Jean Charles
AU - Chen, Christopher
AU - Ikram, M. Arfan
AU - Debette, Stéphanie
AU - Fornage, Myriam
AU - Seshadri, Sudha
N1 - Publisher Copyright: © 2021 the Alzheimer's Association.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - BACKGROUND: Dementia is multifactorial with Alzheimer (AD) and vascular (VaD) pathologies making the largest contributions. There have been over 40 genetic loci associated with AD but genome-wide associations (GWA) underlying VaD remain incompletely identified. The proportion of VaD differs across studies based on study-specific definitions. We hypothesize that common forms of dementia (AD, VaD) will share genetic risk factors. We conducted the largest GWAS to date of VaD and examined the genetic overlap with "all-cause dementia" (ACD). METHOD: A total of 293,544 participants from 9 population-based CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) cohorts, 2 national case-control consortia (ADGC, MEMENTO) and the UKBB contributed 23,986 and 2,935 cases of ACD and VaD, respectively. We ran study-specific analyses adjusting for age, sex, and population structure and meta-analyzed summary statistics using the sample size weighted method implemented in METAL, followed by conditional analyses, fine-mapping and bioinformatic exploration of loci. RESULT: Genome-wide associations with VaD were identified at the APOE locus and at 5 additional loci. One locus has been previously associated with hippocampal volume, verbal memory and CSF amyloid levels (ASTN2); others were near genes associated with hypertension, diabetes and hyperlipidemia (Figures 1 and 2). In addition to previously identified AD loci, we identified novel variants associated with ACD. VaD-related loci also showed sub-threshold associations with ACD that were congruent in direction of effect, thus suggesting additional biological targets underlying ACD. We will additionally present results of an ongoing multiethnic GWAS and insights from pathway analyses and bioinformatic parsing of the identified loci. CONCLUSION: Although VaD is the second most common cause of dementia, the identification of associated genetic loci has been hindered by the heterogeneity of its definition, which necessitates a large sample size to reach genome-wide significance. The newly identified loci could provide novel insights into the pathophysiological mechanisms of dementia and point to new prevention and treatment strategies.
AB - BACKGROUND: Dementia is multifactorial with Alzheimer (AD) and vascular (VaD) pathologies making the largest contributions. There have been over 40 genetic loci associated with AD but genome-wide associations (GWA) underlying VaD remain incompletely identified. The proportion of VaD differs across studies based on study-specific definitions. We hypothesize that common forms of dementia (AD, VaD) will share genetic risk factors. We conducted the largest GWAS to date of VaD and examined the genetic overlap with "all-cause dementia" (ACD). METHOD: A total of 293,544 participants from 9 population-based CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) cohorts, 2 national case-control consortia (ADGC, MEMENTO) and the UKBB contributed 23,986 and 2,935 cases of ACD and VaD, respectively. We ran study-specific analyses adjusting for age, sex, and population structure and meta-analyzed summary statistics using the sample size weighted method implemented in METAL, followed by conditional analyses, fine-mapping and bioinformatic exploration of loci. RESULT: Genome-wide associations with VaD were identified at the APOE locus and at 5 additional loci. One locus has been previously associated with hippocampal volume, verbal memory and CSF amyloid levels (ASTN2); others were near genes associated with hypertension, diabetes and hyperlipidemia (Figures 1 and 2). In addition to previously identified AD loci, we identified novel variants associated with ACD. VaD-related loci also showed sub-threshold associations with ACD that were congruent in direction of effect, thus suggesting additional biological targets underlying ACD. We will additionally present results of an ongoing multiethnic GWAS and insights from pathway analyses and bioinformatic parsing of the identified loci. CONCLUSION: Although VaD is the second most common cause of dementia, the identification of associated genetic loci has been hindered by the heterogeneity of its definition, which necessitates a large sample size to reach genome-wide significance. The newly identified loci could provide novel insights into the pathophysiological mechanisms of dementia and point to new prevention and treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=85124058670&partnerID=8YFLogxK
U2 - 10.1002/alz.056081
DO - 10.1002/alz.056081
M3 - Article
C2 - 35108845
AN - SCOPUS:85124058670
SN - 1552-5260
VL - 17
SP - e056081
JO - Alzheimer's & dementia : the journal of the Alzheimer's Association
JF - Alzheimer's & dementia : the journal of the Alzheimer's Association
ER -
