A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance

Abi Cohen; L Bont; D Engelhard; E Moore; D Fernandez; R Kreisberg-Greenblatt; K Oved; E Eden; John Hays

doi:10.2217/FMB.14.127

A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance

Abi Cohen, L Bont, D Engelhard, E Moore, D Fernandez, R Kreisberg-Greenblatt, K Oved, E Eden, John Hays

Medical Microbiology & Infectious Diseases

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. In this respect, the EU has funded a multidisciplinary project (TAILORED-Treatment) that will develop novel omics-based personalized treatment schemes that have the potential to reduce antibiotic consumption, and help limiting the spread of antibiotic resistance.

Original language	Undefined/Unknown
Pages (from-to)	365-376
Number of pages	12
Journal	Future Microbiology
Volume	10
Issue number	3
DOIs	https://doi.org/10.2217/FMB.14.127
Publication status	Published - 2015

Research programs

EMC MM-04-28-01

Access to Document

10.2217/FMB.14.127

Cite this

@article{a683edc553ea42268ffa550fda11f614,

title = "A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance",

abstract = "The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. In this respect, the EU has funded a multidisciplinary project (TAILORED-Treatment) that will develop novel omics-based personalized treatment schemes that have the potential to reduce antibiotic consumption, and help limiting the spread of antibiotic resistance.",

author = "Abi Cohen and L Bont and D Engelhard and E Moore and D Fernandez and R Kreisberg-Greenblatt and K Oved and E Eden and John Hays",

year = "2015",

doi = "10.2217/FMB.14.127",

language = "Undefined/Unknown",

volume = "10",

pages = "365--376",

journal = "Future Microbiology",

issn = "1746-0913",

publisher = "Future Medicine Ltd.",

number = "3",

}

TY - JOUR

T1 - A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance

AU - Cohen, Abi

AU - Bont, L

AU - Engelhard, D

AU - Moore, E

AU - Fernandez, D

AU - Kreisberg-Greenblatt, R

AU - Oved, K

AU - Eden, E

AU - Hays, John

PY - 2015

Y1 - 2015

N2 - The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. In this respect, the EU has funded a multidisciplinary project (TAILORED-Treatment) that will develop novel omics-based personalized treatment schemes that have the potential to reduce antibiotic consumption, and help limiting the spread of antibiotic resistance.

AB - The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. In this respect, the EU has funded a multidisciplinary project (TAILORED-Treatment) that will develop novel omics-based personalized treatment schemes that have the potential to reduce antibiotic consumption, and help limiting the spread of antibiotic resistance.

U2 - 10.2217/FMB.14.127

DO - 10.2217/FMB.14.127

M3 - Article

SN - 1746-0913

VL - 10

SP - 365

EP - 376

JO - Future Microbiology

JF - Future Microbiology

IS - 3

ER -