A multivariate brain signature for reward

Sebastian P.H. Speer, Christian Keysers, Judit Campdepadrós Barrios, Cas J.S. Teurlings, Ale Smidts, Maarten A.S. Boksem, Tor D. Wager, Valeria Gazzola*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

The processing of reinforcers and punishers is crucial to adapt to an ever changing environment and its dysregulation is prevalent in mental health and substance use disorders. While many human brain measures related to reward have been based on activity in individual brain regions, recent studies indicate that many affective and motivational processes are encoded in distributed systems that span multiple regions. Consequently, decoding these processes using individual regions yields small effect sizes and limited reliability, whereas predictive models based on distributed patterns yield larger effect sizes and excellent reliability. To create such a predictive model for the processes of rewards and losses, termed the Brain Reward Signature (BRS), we trained a model to predict the signed magnitude of monetary rewards on the Monetary Incentive Delay task (MID; N = 39) and achieved a highly significant decoding performance (92% for decoding rewards versus losses). We subsequently demonstrate the generalizability of our signature on another version of the MID in a different sample (92% decoding accuracy; N = 12) and on a gambling task from a large sample (73% decoding accuracy, N = 1084). We further provided preliminary data to characterize the specificity of the signature by illustrating that the signature map generates estimates that significantly differ between rewarding and negative feedback (92% decoding accuracy) but do not differ for conditions that differ in disgust rather than reward in a novel Disgust-Delay Task (N = 39). Finally, we show that passively viewing positive and negatively valenced facial expressions loads positively on our signature, in line with previous studies on morbid curiosity. We thus created a BRS that can accurately predict brain responses to rewards and losses in active decision making tasks, and that possibly relates to information seeking in passive observational tasks.

Original languageEnglish
Article number119990
JournalNeuroImage
Volume271
DOIs
Publication statusPublished - 1 May 2023

Bibliographical note

Funding Information:
European Union's Horizon 2020 research and innovation programme grant, ERC-StG ‘HelpUS’ 758703 (VG)

Funding Information:
We also gratefully acknowledge financial support from the Erasmus Research Institute of Management (ERIM).

Funding Information:
Dutch Research Council (NWO) VICI grant 453-15-009 (CK)

Publisher Copyright:
© 2023

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