A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma

Thaís Armangue; Maarten J. Titulaer; Lidia Sabater; Javier Pardo-Moreno; Nuria Gresa-Arribas; Natalia Barbero-Bordallo; Gordon R. Kelley; Noh Kyung-Ha; Akitoshi Takeda; Takahiro Nagao; Yukitoshi Takahashi; Angélica Lizcano; Aisling S. Carr; Francesc Graus; Josep Dalmau

doi:10.1002/ana.23917

A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma

Thaís Armangue, Maarten J. Titulaer, Lidia Sabater, Javier Pardo-Moreno, Nuria Gresa-Arribas, Natalia Barbero-Bordallo, Gordon R. Kelley, Noh Kyung-Ha, Akitoshi Takeda, Takahiro Nagao, Yukitoshi Takahashi, Angélica Lizcano, Aisling S. Carr, Francesc Graus, Josep Dalmau^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range?=?12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. ANN NEUROL 2014;75:435-441

Original language	English
Pages (from-to)	435-441
Number of pages	7
Journal	Annals of Neurology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1002/ana.23917
Publication status	Published - Mar 2014
Externally published	Yes

Access to Document

10.1002/ana.23917

Cite this

Armangue, T., Titulaer, M. J., Sabater, L., Pardo-Moreno, J., Gresa-Arribas, N., Barbero-Bordallo, N., Kelley, G. R., Kyung-Ha, N., Takeda, A., Nagao, T., Takahashi, Y., Lizcano, A., Carr, A. S., Graus, F., & Dalmau, J. (2014). A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma. Annals of Neurology, 75(3), 435-441. https://doi.org/10.1002/ana.23917

@article{0a7e938892c14b1b87252cf6ae2caa1f,

title = "A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma",

abstract = "Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range?=?12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. ANN NEUROL 2014;75:435-441",

author = "Tha{\'i}s Armangue and Titulaer, {Maarten J.} and Lidia Sabater and Javier Pardo-Moreno and Nuria Gresa-Arribas and Natalia Barbero-Bordallo and Kelley, {Gordon R.} and Noh Kyung-Ha and Akitoshi Takeda and Takahiro Nagao and Yukitoshi Takahashi and Ang{\'e}lica Lizcano and Carr, {Aisling S.} and Francesc Graus and Josep Dalmau",

year = "2014",

month = mar,

doi = "10.1002/ana.23917",

language = "English",

volume = "75",

pages = "435--441",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley & Sons Inc.",

number = "3",

}

Armangue, T, Titulaer, MJ, Sabater, L, Pardo-Moreno, J, Gresa-Arribas, N, Barbero-Bordallo, N, Kelley, GR, Kyung-Ha, N, Takeda, A, Nagao, T, Takahashi, Y, Lizcano, A, Carr, AS, Graus, F & Dalmau, J 2014, 'A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma', Annals of Neurology, vol. 75, no. 3, pp. 435-441. https://doi.org/10.1002/ana.23917

TY - JOUR

T1 - A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma

AU - Armangue, Thaís

AU - Titulaer, Maarten J.

AU - Sabater, Lidia

AU - Pardo-Moreno, Javier

AU - Gresa-Arribas, Nuria

AU - Barbero-Bordallo, Natalia

AU - Kelley, Gordon R.

AU - Kyung-Ha, Noh

AU - Takeda, Akitoshi

AU - Nagao, Takahiro

AU - Takahashi, Yukitoshi

AU - Lizcano, Angélica

AU - Carr, Aisling S.

AU - Graus, Francesc

AU - Dalmau, Josep

PY - 2014/3

Y1 - 2014/3

N2 - Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range?=?12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. ANN NEUROL 2014;75:435-441

AB - Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range?=?12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. ANN NEUROL 2014;75:435-441

UR - http://www.scopus.com/inward/record.url?scp=84897999009&partnerID=8YFLogxK

U2 - 10.1002/ana.23917

DO - 10.1002/ana.23917

M3 - Article

C2 - 23613036

AN - SCOPUS:84897999009

SN - 0364-5134

VL - 75

SP - 435

EP - 441

JO - Annals of Neurology

JF - Annals of Neurology

IS - 3

ER -

A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma

Abstract

Access to Document

Other files and links

Fingerprint

Cite this