A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

F Helderman; I Manoch; M Breeuwer; U Kose; Olaf Schouten; Marc Sambeek; D Poldermans; Peter Pattynama; W Wisselink; Ton van der Steen; R (Rob) Krams

doi:10.1007/s11517-008-0358-3

A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

F Helderman, I Manoch, M Breeuwer, U Kose, Olaf Schouten, Marc Sambeek, D Poldermans, Peter Pattynama, W Wisselink, Ton van der Steen, R (Rob) Krams

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

Original language	Undefined/Unknown
Pages (from-to)	1121-1127
Number of pages	7
Journal	Medical & Biological Engineering & Computing
Volume	46
Issue number	11
DOIs	https://doi.org/10.1007/s11517-008-0358-3
Publication status	Published - 2008

Research programs

EMC COEUR-01-43-01
EMC NIHES-03-30-01

Access to Document

10.1007/s11517-008-0358-3

http://hdl.handle.net/1765/12654

Cite this

Helderman, F., Manoch, I., Breeuwer, M., Kose, U., Schouten, O., Sambeek, M., Poldermans, D., Pattynama, P., Wisselink, W., van der Steen, T., & Krams, R. (2008). A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness. Medical & Biological Engineering & Computing, 46(11), 1121-1127. https://doi.org/10.1007/s11517-008-0358-3

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abstract = "Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.",

author = "F Helderman and I Manoch and M Breeuwer and U Kose and Olaf Schouten and Marc Sambeek and D Poldermans and Peter Pattynama and W Wisselink and {van der Steen}, Ton and Krams, {R (Rob)}",

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Helderman, F, Manoch, I, Breeuwer, M, Kose, U, Schouten, O, Sambeek, M, Poldermans, D, Pattynama, P, Wisselink, W, van der Steen, T & Krams, R 2008, 'A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness', Medical & Biological Engineering & Computing, vol. 46, no. 11, pp. 1121-1127. https://doi.org/10.1007/s11517-008-0358-3

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T1 - A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness

AU - Helderman, F

AU - Manoch, I

AU - Breeuwer, M

AU - Kose, U

AU - Schouten, Olaf

AU - Sambeek, Marc

AU - Poldermans, D

AU - Pattynama, Peter

AU - Wisselink, W

AU - van der Steen, Ton

AU - Krams, R (Rob)

PY - 2008

Y1 - 2008

N2 - Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

AB - Aneurysms of the abdominal aorta enlarge until rupture occurs. We assume that this is the result of remodelling to restore wall stress. We developed a numerical model to predict aneurysm expansion based on this assumption. In addition, we obtained aneurysm geometry of 11 patients from computed tomography angiographic images to obtain patient specific calculations. The assumption of a wall stress related expansion indeed resulted in a series of local expansions, adjusting global geometry in an exponential fashion similar as in patients. Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings.

U2 - 10.1007/s11517-008-0358-3

DO - 10.1007/s11517-008-0358-3

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VL - 46

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EP - 1127

JO - Medical & Biological Engineering & Computing

JF - Medical & Biological Engineering & Computing

IS - 11

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