A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Haelg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia TsoutsouRainer Fietkau, Oliver J. Ott, Pirus Ghadjar, Oliver Riesterer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Purpose The combination of hyperthermia (HT) with radio(chemo)therapy or chemotherapy (CT) is an established treatment strategy for specific indications. Its application in routine clinical practice in Europe depends on regulatory and local conditions. We conducted a survey among European clinical centers to determine current practice of HT. Methods A questionnaire with 22 questions was sent to 24 European HT centers. The questions were divided into two main categories. The first category assessed how many patients are treated with HT in combination with radio(chemo)therapy or CT for specific indications per year. The second category addressed which hyperthermia parameters are recorded. Analysis was performed using descriptive methods. Results The response rate was 71% (17/24) and 16 centers were included in this evaluation. Annually, these 16 centers treat approximately 637 patients using HT in combination with radio(chemo)therapy or CT. On average, 34% (range: 3-100%) of patients are treated in clinical study protocols. Temperature readings and the time interval between HT and radio(chemo)therapy or CT are recorded in 13 (81%) and 9 (56%) centers, respectively. The thermal dose quality parameter "cumulative equivalent minutes at 43 °C" (CEM43 °C) is only evaluated in five (31%) centers for each HT session. With regard to treatment sequence, 8 (50%) centers administer HT before radio(chemo)therapy and the other 8 in the reverse order. Conclusion There is a significant heterogeneity among European HT centers as to the indications treated and the recording of thermometric parameters. More evidence from clinical studies is necessary to achieve standardization of HT practice.

Original languageEnglish
Pages (from-to)436-444
Number of pages9
JournalStrahlentherapie und Onkologie
Issue number5
Early online date29 Aug 2022
Publication statusPublished - May 2023

Bibliographical note

Funding Information:
The Hyperboost project ( https://www.hyperboost.eu/ ) has received funding from the European Commission under the European Union’s Horizon 2020 research and innovation program under grant agreement no. 955625 (H2020-MSCA-ITN-2020-955625).

Publisher Copyright:
© 2022, The Author(s).


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