A perspective on enhancing representative samples in developmental human neuroscience: Connecting science to society

Kayla H. Green*, Ilse H. Van De Groep, Lysanne W. Te Brinke, Renske van der Cruijsen, Fabienne van Rossenberg, Hanan El Marroun

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
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Marginalized groups are often underrepresented in human developmental neuroscientific studies. This is problematic for the generalizability of findings about brain-behavior mechanisms, as well as for the validity, reliability, and reproducibility of results. In the present paper we discuss selection bias in cohort studies, which is known to contribute to the underrepresentation of marginalized groups. First, we address the issue of exclusion bias, as marginalized groups are sometimes excluded from studies because they do not fit the inclusion criteria. Second, we highlight examples of sampling bias. Recruitment strategies are not always designed to reach and attract a diverse group of youth. Third, we explain how diversity can be lost due to attrition of marginalized groups in longitudinal cohort studies. We provide experience- and evidence-based recommendations to stimulate neuroscientists to enhance study population representativeness via science communication and citizen science with youth. By connecting science to society, researchers have the opportunity to establish sustainable and equal researcher-community relationships, which can positively contribute to tackling selection biases.

Original languageEnglish
Article number981657
JournalFrontiers in Integrative Neuroscience
Publication statusPublished - 2 Sept 2022

Bibliographical note

Funding Information:
This work was supported by the Stichting Volksbond Rotterdam, the NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (Grant Number 27853), Netherlands Organization for Scientific Research (NWO) Aspasia grant (No. 015.016.056), and by the NWO Spinoza prize awarded to Eveline A. Crone. The funding agencies had no role in the design, preparation, review or approval of the manuscript, and the decision to submit it for publication.

Publisher Copyright:
Copyright © 2022 Green, Van De Groep, Te Brinke, van der Cruijsen, van Rossenberg and El Marroun.


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