A perspective on muscle phenotyping in musculoskeletal research

Ines Foessl; Cheryl L. Ackert-Bicknell; Erika Kague; Faidra Laskou; Franz Jakob; David Karasik; Barbara Obermayer-Pietsch; Nerea Alonso; Åshild Bjørnerem; Maria Luisa Brandi; Björn Busse; Ângelo Calado; Alper Han Cebi; Maria Christou; Kathleen M. Curran; Jannie Dahl Hald; Maria Donatella Semeraro; Eleni Douni; Emma L. Duncan; Ivan Duran; Melissa M. Formosa; Yankel Gabet; Samuel Ghatan; Artemis Gkitakou; Eva Maria Hassler; Wolfgang Högler; Terhi J. Heino; Gretl Hendrickx; Patricia Khashayar; Douglas P. Kiel; Fjorda Koromani; Bente Langdahl; Philippe Lopes; Outi Mäkitie; Antonio Maurizi; Carolina Medina-Gomez; Evangelia Ntzani; Claes Ohlsson; Vid Prijatelj; Raquel Rabionet; Sjur Reppe; Fernando Rivadeneira; Gennady Roshchupkin; Neha Sharma; Kent Søe; Unnur Styrkarsdottir; Pavel Szulc; Jeroen van de Peppel; Bram van der Eerden; M. Carola Zillikens

doi:10.1016/j.tem.2024.01.004

A perspective on muscle phenotyping in musculoskeletal research

Ines Foessl^*, Cheryl L. Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M. Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L. Duncan, Ivan DuranMelissa M. Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J. Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P. Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Jeroen van de Peppel, Bram van der Eerden, M. Carola Zillikens

^*Corresponding author for this work

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Abstract

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

Original language	English
Pages (from-to)	478-489
Number of pages	12
Journal	Trends in Endocrinology and Metabolism
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.tem.2024.01.004
Publication status	Published - Jun 2024

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Foessl, I., Ackert-Bicknell, C. L., Kague, E., Laskou, F., Jakob, F., Karasik, D., Obermayer-Pietsch, B., Alonso, N., Bjørnerem, Å., Brandi, M. L., Busse, B., Calado, Â., Cebi, A. H., Christou, M., Curran, K. M., Hald, J. D., Semeraro, M. D., Douni, E., Duncan, E. L., ... Zillikens, M. C. (2024). A perspective on muscle phenotyping in musculoskeletal research. Trends in Endocrinology and Metabolism, 35(6), 478-489. https://doi.org/10.1016/j.tem.2024.01.004

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title = "A perspective on muscle phenotyping in musculoskeletal research",

abstract = "Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term {\textquoteleft}osteosarcopenia{\textquoteright}, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action {\textquoteleft}Genomics of MusculoSkeletal traits Translational Network{\textquoteright} (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.",

author = "Ines Foessl and Ackert-Bicknell, {Cheryl L.} and Erika Kague and Faidra Laskou and Franz Jakob and David Karasik and Barbara Obermayer-Pietsch and Nerea Alonso and {\AA}shild Bj{\o}rnerem and Brandi, {Maria Luisa} and Bj{\"o}rn Busse and {\^A}ngelo Calado and Cebi, {Alper Han} and Maria Christou and Curran, {Kathleen M.} and Hald, {Jannie Dahl} and Semeraro, {Maria Donatella} and Eleni Douni and Duncan, {Emma L.} and Ivan Duran and Formosa, {Melissa M.} and Yankel Gabet and Samuel Ghatan and Artemis Gkitakou and Hassler, {Eva Maria} and Wolfgang H{\"o}gler and Heino, {Terhi J.} and Gretl Hendrickx and Patricia Khashayar and Kiel, {Douglas P.} and Fjorda Koromani and Bente Langdahl and Philippe Lopes and Outi M{\"a}kitie and Antonio Maurizi and Carolina Medina-Gomez and Evangelia Ntzani and Claes Ohlsson and Vid Prijatelj and Raquel Rabionet and Sjur Reppe and Fernando Rivadeneira and Gennady Roshchupkin and Neha Sharma and Kent S{\o}e and Unnur Styrkarsdottir and Pavel Szulc and {van de Peppel}, Jeroen and {van der Eerden}, Bram and Zillikens, {M. Carola}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = jun,

doi = "10.1016/j.tem.2024.01.004",

language = "English",

volume = "35",

pages = "478--489",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "6",

}

Foessl, I, Ackert-Bicknell, CL, Kague, E, Laskou, F, Jakob, F, Karasik, D, Obermayer-Pietsch, B, Alonso, N, Bjørnerem, Å, Brandi, ML, Busse, B, Calado, Â, Cebi, AH, Christou, M, Curran, KM, Hald, JD, Semeraro, MD, Douni, E, Duncan, EL, Duran, I, Formosa, MM, Gabet, Y, Ghatan, S, Gkitakou, A, Hassler, EM, Högler, W, Heino, TJ, Hendrickx, G, Khashayar, P, Kiel, DP, Koromani, F, Langdahl, B, Lopes, P, Mäkitie, O, Maurizi, A, Medina-Gomez, C, Ntzani, E, Ohlsson, C, Prijatelj, V, Rabionet, R, Reppe, S, Rivadeneira, F , Roshchupkin, G, Sharma, N, Søe, K, Styrkarsdottir, U, Szulc, P, van de Peppel, J , van der Eerden, B & Zillikens, MC 2024, 'A perspective on muscle phenotyping in musculoskeletal research', Trends in Endocrinology and Metabolism, vol. 35, no. 6, pp. 478-489. https://doi.org/10.1016/j.tem.2024.01.004

TY - JOUR

T1 - A perspective on muscle phenotyping in musculoskeletal research

AU - Foessl, Ines

AU - Ackert-Bicknell, Cheryl L.

AU - Kague, Erika

AU - Laskou, Faidra

AU - Jakob, Franz

AU - Karasik, David

AU - Obermayer-Pietsch, Barbara

AU - Alonso, Nerea

AU - Bjørnerem, Åshild

AU - Brandi, Maria Luisa

AU - Busse, Björn

AU - Calado, Ângelo

AU - Cebi, Alper Han

AU - Christou, Maria

AU - Curran, Kathleen M.

AU - Hald, Jannie Dahl

AU - Semeraro, Maria Donatella

AU - Douni, Eleni

AU - Duncan, Emma L.

AU - Duran, Ivan

AU - Formosa, Melissa M.

AU - Gabet, Yankel

AU - Ghatan, Samuel

AU - Gkitakou, Artemis

AU - Hassler, Eva Maria

AU - Högler, Wolfgang

AU - Heino, Terhi J.

AU - Hendrickx, Gretl

AU - Khashayar, Patricia

AU - Kiel, Douglas P.

AU - Koromani, Fjorda

AU - Langdahl, Bente

AU - Lopes, Philippe

AU - Mäkitie, Outi

AU - Maurizi, Antonio

AU - Medina-Gomez, Carolina

AU - Ntzani, Evangelia

AU - Ohlsson, Claes

AU - Prijatelj, Vid

AU - Rabionet, Raquel

AU - Reppe, Sjur

AU - Rivadeneira, Fernando

AU - Roshchupkin, Gennady

AU - Sharma, Neha

AU - Søe, Kent

AU - Styrkarsdottir, Unnur

AU - Szulc, Pavel

AU - van de Peppel, Jeroen

AU - van der Eerden, Bram

AU - Zillikens, M. Carola

PY - 2024/6

Y1 - 2024/6

N2 - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

AB - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

UR - http://www.scopus.com/inward/record.url?scp=85189075377&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2024.01.004

DO - 10.1016/j.tem.2024.01.004

M3 - Review article

C2 - 38553405

AN - SCOPUS:85189075377

SN - 1043-2760

VL - 35

SP - 478

EP - 489

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 6

ER -

A perspective on muscle phenotyping in musculoskeletal research

Abstract

Bibliographical note

UN SDGs

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