A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

Hieab H H Adams; Saima Hilal; Petra Schwingenschuh; Katharina Wittfeld; Sven J van der Lee; Charles DeCarli; Meike W Vernooij; Petra Katschnig-Winter; Mohamad Habes; Christopher Chen; Sudha Seshadri; Cornelia M van Duijn; M Kamran Ikram; Hans J Grabe; Reinhold Schmidt; M Arfan Ikram

doi:10.1016/j.dadm.2015.10.004

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

Hieab H H Adams
, Saima Hilal
, Petra Schwingenschuh
, Katharina Wittfeld
, Sven J van der Lee
, Charles DeCarli
, Meike W Vernooij
, Petra Katschnig-Winter
, Mohamad Habes
, Christopher Chen
, Sudha Seshadri
, Cornelia M van Duijn
, M Kamran Ikram
, Hans J Grabe
, Reinhold Schmidt
, M Arfan Ikram

Medical University of Graz
German Center for Neurodegenerative Diseases
University of California at Davis
Clarion University of Pennsylvania
MOH Holdings Pte Ltd.
Boston University School of Medicine
National University Hospital (Singapore)
University Medicine Greifswald
Department of Epidemiology & Biostatistics
National University of Singapore

Research output: Contribution to journal › Article › Academic › peer-review

58 Citations (Scopus)

43 Downloads (Pure)

Abstract

INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field.

METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium.

RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region.

DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

Original language	English
Pages (from-to)	513-520
Number of pages	8
Journal	Alzheimer's & Dementia: diagnosis, assessment & disease monitoring
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/j.dadm.2015.10.004
Publication status	Published - Dec 2015

Research programs

EMC NIHES-03-30-02

Access to Document

10.1016/j.dadm.2015.10.004Licence: CC BY-NC-ND

A priori collaboration in population imagingFinal published version, 506 KBLicence: CC BY-NC-ND

Cite this

Adams, H. H. H., Hilal, S., Schwingenschuh, P., Wittfeld, K., van der Lee, S. J., DeCarli, C., Vernooij, M. W., Katschnig-Winter, P., Habes, M., Chen, C., Seshadri, S., van Duijn, C. M., Ikram, M. K., Grabe, H. J., Schmidt, R., & Ikram, M. A. (2015). A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. Alzheimer's & Dementia: diagnosis, assessment & disease monitoring, 1(4), 513-520. https://doi.org/10.1016/j.dadm.2015.10.004

@article{e3b6088f9f6c4d11b83f4cb1e28f8387,

title = "A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium",

abstract = "INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field.METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium.RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region.DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.",

author = "Adams, \{Hieab H H\} and Saima Hilal and Petra Schwingenschuh and Katharina Wittfeld and \{van der Lee\}, \{Sven J\} and Charles DeCarli and Vernooij, \{Meike W\} and Petra Katschnig-Winter and Mohamad Habes and Christopher Chen and Sudha Seshadri and \{van Duijn\}, \{Cornelia M\} and Ikram, \{M Kamran\} and Grabe, \{Hans J\} and Reinhold Schmidt and Ikram, \{M Arfan\}",

year = "2015",

month = dec,

doi = "10.1016/j.dadm.2015.10.004",

language = "English",

volume = "1",

pages = "513--520",

journal = "Alzheimer's \& Dementia: diagnosis, assessment \& disease monitoring",

issn = "2352-8729",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

Adams, HHH, Hilal, S, Schwingenschuh, P, Wittfeld, K, van der Lee, SJ, DeCarli, C, Vernooij, MW, Katschnig-Winter, P, Habes, M, Chen, C, Seshadri, S, van Duijn, CM, Ikram, MK, Grabe, HJ, Schmidt, R & Ikram, MA 2015, 'A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium', Alzheimer's & Dementia: diagnosis, assessment & disease monitoring, vol. 1, no. 4, pp. 513-520. https://doi.org/10.1016/j.dadm.2015.10.004

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. / Adams, Hieab H H; Hilal, Saima; Schwingenschuh, Petra et al.
In: Alzheimer's & Dementia: diagnosis, assessment & disease monitoring, Vol. 1, No. 4, 12.2015, p. 513-520.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A priori collaboration in population imaging

T2 - The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

AU - Adams, Hieab H H

AU - Hilal, Saima

AU - Schwingenschuh, Petra

AU - Wittfeld, Katharina

AU - van der Lee, Sven J

AU - DeCarli, Charles

AU - Vernooij, Meike W

AU - Katschnig-Winter, Petra

AU - Habes, Mohamad

AU - Chen, Christopher

AU - Seshadri, Sudha

AU - van Duijn, Cornelia M

AU - Ikram, M Kamran

AU - Grabe, Hans J

AU - Schmidt, Reinhold

AU - Ikram, M Arfan

PY - 2015/12

Y1 - 2015/12

N2 - INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field.METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium.RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region.DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

AB - INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field.METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium.RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region.DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

U2 - 10.1016/j.dadm.2015.10.004

DO - 10.1016/j.dadm.2015.10.004

M3 - Article

C2 - 27239529

SN - 2352-8729

VL - 1

SP - 513

EP - 520

JO - Alzheimer's & Dementia: diagnosis, assessment & disease monitoring

JF - Alzheimer's & Dementia: diagnosis, assessment & disease monitoring

IS - 4

ER -

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

Abstract

Research programs

Access to Document

Fingerprint

Cite this