A Prominent Role for DC-SIGN(+) Dendritic Cells in Initiation and Dissemination of Measles Virus Infection in Non-Human Primates

AW Mesman, Rory de Vries, S McQuaid, WP Duprex, Rik de Swart, TBH Geijtenbeek

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
6 Downloads (Pure)

Abstract

Measles virus (MV) is a highly contagious virus that is transmitted by aerosols. During systemic infection, CD150(+) T and B lymphocytes in blood and lymphoid tissues are the main cells infected by pathogenic MV. However, it is unclear which cell types are the primary targets for MV in the lungs and how the virus reaches the lymphoid tissues. In vitro studies have shown that dendritic cell (DC) C-type lectin DC-SIGN captures MV, leading to infection of DCs as well as transmission to lymphocytes. However, evidence of DC-SIGN-mediated transmission in vivo has not been established. Here we identified DC-SIGN hi DCs as first target cells in vivo and demonstrate that macaque DC-SIGN functions as an attachment receptor for MV. Notably, DC-SIGN hi cells from macaque broncho-alveolar lavage and lymph nodes transmit MV to B lymphocytes, providing in vivo support for an important role for DCs in both initiation and dissemination of MV infection. Citation: Mesman AW, de Vries RD, McQuaid S, Duprex WP, de Swart RL, et al. (2012) A Prominent Role for DC-SIGN(+) Dendritic Cells in Initiation and Dissemination of Measles Virus Infection in Non-Human Primates. PLoS ONE 7(12): e49573. doi:10.1371/journal.pone.0049573
Original languageUndefined/Unknown
JournalPLoS One (print)
Volume7
Issue number12
DOIs
Publication statusPublished - 2012

Cite this