A prospective open study of the efficacy of high-dose recombinant hepatitis B rechallenge vaccination in HIV-infected patients

T.E.M.S. De Vries - Sluijs, Bettina Hansen, Gerard Doornum, Tirza Springeling, NM Evertsz, Rob de Man, Marchina Ende

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Double-dose hepatitis B virus revaccination of human immunodeficiency virus (HIV) -infected patients proved to be effective in 50.7% of 144 patients who had previously failed to respond to standard doses. In the multivariate analysis, female patients were found to have a significantly better response (P = .03). The effect of age on the response depended on the viral load at the time of revaccination. For patients with a detectable HIV RNA load, the effect of age was stronger (odds ratio [ OR], 0.34 per 10 years older [ 95% confidence interval {CI}, 0.16-0.72]; P = .005) than for patients with an undetectable HIV RNA load (OR, 0.74 per 10 years older [ 95% CI, 0.50-1.09]; P = .12).
Original languageUndefined/Unknown
Pages (from-to)292-294
Number of pages3
JournalJournal of Infectious Diseases
Issue number2
Publication statusPublished - 2008

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