TY - JOUR
T1 - A second update on mapping the human genetic architecture of COVID-19
AU - The COVID-19 Host Genetics Initiative
AU - Kanai, Masahiro
AU - Andrews, Shea J.
AU - Cordioli, Mattia
AU - Stevens, Christine
AU - Neale, Benjamin M.
AU - Daly, Mark
AU - Ganna, Andrea
AU - Pathak, Gita A.
AU - Iwasaki, Akiko
AU - Karjalainen, Juha
AU - Mehtonen, Juha
AU - Pirinen, Matti
AU - Chwialkowska, Karolina
AU - Trankiem, Amy
AU - Balaconis, Mary K.
AU - Veerapen, Kumar
AU - Wolford, Brooke N.
AU - Ahmad, Hajar Fauzan
AU - Andrews, Shea
AU - von Hohenstaufen Puoti, Kathrin Aprile
AU - Boer, Cindy
AU - Boua, Palwende R.
AU - Butler-Laporte, Guillaume
AU - Cadilla, Carmen L.
AU - Colombo, Francesca
AU - Douillard, Venceslas
AU - Dueker, Nicole
AU - Dutta, Atanu Kumar
AU - El-Sherbiny, Yasser M.
AU - Eltoukhy, Madonna M.
AU - Esmaeeli, Sahar
AU - Faucon, Annika
AU - Fave, Marie Julie
AU - Jansen, Philip
AU - Medina-Gómez, Carolina
AU - Prijatelj, Vid
AU - Prokić, Ivana
AU - Teumer, Alexander
AU - Vallerga, Costanza L.
AU - van der Laan, Sander
AU - Ikram, M. Arfan
AU - Uitterlinden, Andre G.
AU - Yang, Jian
AU - Thompson, Christopher
AU - Peters, Mark
AU - Payne, Caroline
AU - Johnson, Laura
AU - Smith, Tim
AU - García-García, Lourdes
AU - Martín, Vicente
PY - 2023/9/7
Y1 - 2023/9/7
N2 - Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development. Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release2. The increased number of candidate genes at the identified loci helped to map three major biological pathways that are involved in susceptibility and severity: viral entry, airway defence in mucus and type I interferon. [...]
AB - Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development. Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release2. The increased number of candidate genes at the identified loci helped to map three major biological pathways that are involved in susceptibility and severity: viral entry, airway defence in mucus and type I interferon. [...]
UR - https://www.scopus.com/pages/publications/85178660706
U2 - 10.1038/s41586-023-06355-3
DO - 10.1038/s41586-023-06355-3
M3 - Article
C2 - 37674002
AN - SCOPUS:85178660706
SN - 0028-0836
VL - 621
SP - E7-E26
JO - Nature
JF - Nature
IS - 7977
ER -