TY - JOUR
T1 - A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis
AU - Putera, Ikhwanuliman
AU - Schrijver, Benjamin
AU - Kolijn, P. Martijn
AU - van Stigt, Astrid C.
AU - ten Berge, Josianne C.E.M.
AU - IJspeert, Hanna
AU - Nagtzaam, Nicole M.A.
AU - Swagemakers, Sigrid M.A.
AU - van Laar, Jan A.M.
AU - Agrawal, Rupesh
AU - Rombach, Saskia M.
AU - van Hagen, P. Martin
AU - La Distia Nora, Rina
AU - Dik, Willem A.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9/10
Y1 - 2024/9/10
N2 - Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two distinct geographically separated cohorts: sarcoidosis from the Netherlands and TB from Indonesia. A total of 192 and 102 differentially expressed proteins were found in sarcoidosis and active pulmonary TB compared to their geographical healthy controls, respectively. While substantial overlap exists in the immune-related pathways involved in both diseases, activation of B cell activating factor (BAFF) signaling and proliferation-inducing ligand (APRIL) mediated signaling pathways was specifically associated with sarcoidosis. We identified a B-lymphocyte activation signature consisting of BAFF, TNFRSF13B/TACI, TRAF2, IKBKG, MAPK9, NFATC1, and DAPP1 that was associated with sarcoidosis, regardless of the presence of uveitis. In summary, a difference in B-lymphocyte activation is a key discriminative immunological feature between sarcoidosis/ocular sarcoidosis (OS) and TB/ocular TB (OTB).
AB - Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two distinct geographically separated cohorts: sarcoidosis from the Netherlands and TB from Indonesia. A total of 192 and 102 differentially expressed proteins were found in sarcoidosis and active pulmonary TB compared to their geographical healthy controls, respectively. While substantial overlap exists in the immune-related pathways involved in both diseases, activation of B cell activating factor (BAFF) signaling and proliferation-inducing ligand (APRIL) mediated signaling pathways was specifically associated with sarcoidosis. We identified a B-lymphocyte activation signature consisting of BAFF, TNFRSF13B/TACI, TRAF2, IKBKG, MAPK9, NFATC1, and DAPP1 that was associated with sarcoidosis, regardless of the presence of uveitis. In summary, a difference in B-lymphocyte activation is a key discriminative immunological feature between sarcoidosis/ocular sarcoidosis (OS) and TB/ocular TB (OTB).
UR - http://www.scopus.com/inward/record.url?scp=85203548426&partnerID=8YFLogxK
U2 - 10.1038/s42003-024-06822-1
DO - 10.1038/s42003-024-06822-1
M3 - Article
C2 - 39256610
AN - SCOPUS:85203548426
SN - 2399-3642
VL - 7
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1114
ER -