A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children

A. Laura Nijstad*, Evelien de Vos-Kerkhof, Catherine F. Enters-Weijnen, Marianne D. van de Wetering, Wim J.E. Tissing, Lidwien M. Hanff, Rogier Lange, Matthijs M. Tibben, Hilde Rosing, Arief Lalmohamed, C. Michel Zwaan, Alwin D.R. Huitema

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Introduction: Aprepitant is used for the treatment of chemotherapy induced nausea and vomiting. A liquid formulation is needed for treatment of young children. However, the commercial (powder for) suspension was not available worldwide for a prolonged period of time and, therefore, a 10 mg/mL aprepitant oral suspension was extemporarily prepared to prevent suboptimal antiemetic treatment. The current pharmacokinetic study was developed to investigate whether this extemporaneous oral suspension offers an appropriate treatment option. Methods: From 49 pediatric patients (0.7–17.9 years) 235 plasma concentrations were collected. Patients were either treated with our extemporaneous oral suspension (n = 26; 53%), commercially available capsules (n = 18; 37%), or the intravenous prodrug formulation of aprepitant (fosaprepitant, n = 5; 10%). Pharmacokinetic analyses were performed using nonlinear mixed effects modelling. Results: A one-compartment model adequately described the pharmacokinetics of aprepitant in children. The bioavailability of the extemporaneous oral suspension was not significantly different to that of the capsules (P = 0.26). The observed bioavailability throughout the total population was 83% (95% CI 69%-97%). The absorption of the extemporaneous oral suspension was 39.4% (95%CI 19.5–57.4%) faster than that of capsules (mean absorption time of 1.78 h (95%CI 1.32–2.35), but was comparable to that of the commercial oral suspension. The median area under the curve after (fos)aprepitant was 22.2 mg/L*h (range 8.9–50.3 mg/L*h) on day 1. Conclusion: Our extemporaneous oral suspension is an adequate alternative for the commercially (un)available oral suspension in young children. An adequate exposure to aprepitant in children was yielded and the bioavailability of the extemporaneous suspension was comparable to capsules.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalJournal of Oncology Pharmacy Practice
Volume29
Issue number4
Early online date4 Apr 2022
DOIs
Publication statusPublished - Jun 2023

Bibliographical note

Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Children Cancer-free Foundation Stichting Kinderen Kankervrij, (grant number 320).

Publisher Copyright: © The Author(s) 2022.

Fingerprint

Dive into the research topics of 'A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children'. Together they form a unique fingerprint.

Cite this