TY - JOUR
T1 - A soft robotic total artificial hybrid heart
AU - Arfaee, Maziar
AU - Vis, Annemijn
AU - Bartels, Paul A.A.
AU - van Laake, Lucas C.
AU - Lorenzon, Lucrezia
AU - Ibrahim, Dina M.
AU - Zrinscak, Debora
AU - Smits, Anthal I.P.M.
AU - Henseler, Andreas
AU - Cianchetti, Matteo
AU - Dankers, Patricia Y.W.
AU - Bouten, Carlijn V.C.
AU - Overvelde, Johannes T.B.
AU - Kluin, Jolanda
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/6/3
Y1 - 2025/6/3
N2 - End-stage heart failure is a deadly disease. Current total artificial hearts (TAHs) carry high mortality and morbidity and offer low quality of life. To overcome current biocompatibility issues, we propose the concept of a soft robotic, hybrid (pumping power comes from soft robotics, innerlining from the patient’s own cells) TAH. The device features a pneumatically driven actuator (septum) between two ventricles and is coated with supramolecular polymeric materials to promote anti-thrombotic and tissue engineering properties. In vitro, the Hybrid Heart pumps 5.7 L/min and mimics the native heart’s adaptive function. Proof-of-concept studies in rats and an acute goat model demonstrate the Hybrid Heart’s potential for clinical use and improved biocompatibility. This paper presents the first proof-of-concept of a soft, biocompatible TAH by providing a platform using soft robotics and tissue engineering to create new horizons in heart failure and transplantation medicine.
AB - End-stage heart failure is a deadly disease. Current total artificial hearts (TAHs) carry high mortality and morbidity and offer low quality of life. To overcome current biocompatibility issues, we propose the concept of a soft robotic, hybrid (pumping power comes from soft robotics, innerlining from the patient’s own cells) TAH. The device features a pneumatically driven actuator (septum) between two ventricles and is coated with supramolecular polymeric materials to promote anti-thrombotic and tissue engineering properties. In vitro, the Hybrid Heart pumps 5.7 L/min and mimics the native heart’s adaptive function. Proof-of-concept studies in rats and an acute goat model demonstrate the Hybrid Heart’s potential for clinical use and improved biocompatibility. This paper presents the first proof-of-concept of a soft, biocompatible TAH by providing a platform using soft robotics and tissue engineering to create new horizons in heart failure and transplantation medicine.
UR - http://www.scopus.com/inward/record.url?scp=105007139200&partnerID=8YFLogxK
U2 - 10.1038/s41467-025-60372-6
DO - 10.1038/s41467-025-60372-6
M3 - Article
C2 - 40461487
AN - SCOPUS:105007139200
SN - 2041-1723
VL - 16
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5146
ER -